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5TLA

Crystal structure of mouse ISG15

Functional Information from GO Data
ChainGOidnamespacecontents
A0002682biological_processregulation of immune system process
A0003735molecular_functionstructural constituent of ribosome
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0007229biological_processintegrin-mediated signaling pathway
A0009615biological_processresponse to virus
A0009617biological_processresponse to bacterium
A0019941biological_processmodification-dependent protein catabolic process
A0022626cellular_componentcytosolic ribosome
A0030501biological_processpositive regulation of bone mineralization
A0031386molecular_functionprotein tag activity
A0031397biological_processnegative regulation of protein ubiquitination
A0032020biological_processISG15-protein conjugation
A0032461biological_processpositive regulation of protein oligomerization
A0032649biological_processregulation of type II interferon production
A0032728biological_processpositive regulation of interferon-beta production
A0032729biological_processpositive regulation of type II interferon production
A0032733biological_processpositive regulation of interleukin-10 production
A0034340biological_processresponse to type I interferon
A0042742biological_processdefense response to bacterium
A0045071biological_processnegative regulation of viral genome replication
A0045087biological_processinnate immune response
A0045648biological_processpositive regulation of erythrocyte differentiation
A0051240biological_processpositive regulation of multicellular organismal process
A0051607biological_processdefense response to virus
A0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
A0070585biological_processprotein localization to mitochondrion
B0002682biological_processregulation of immune system process
B0003735molecular_functionstructural constituent of ribosome
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0007229biological_processintegrin-mediated signaling pathway
B0009615biological_processresponse to virus
B0009617biological_processresponse to bacterium
B0019941biological_processmodification-dependent protein catabolic process
B0022626cellular_componentcytosolic ribosome
B0030501biological_processpositive regulation of bone mineralization
B0031386molecular_functionprotein tag activity
B0031397biological_processnegative regulation of protein ubiquitination
B0032020biological_processISG15-protein conjugation
B0032461biological_processpositive regulation of protein oligomerization
B0032649biological_processregulation of type II interferon production
B0032728biological_processpositive regulation of interferon-beta production
B0032729biological_processpositive regulation of type II interferon production
B0032733biological_processpositive regulation of interleukin-10 production
B0034340biological_processresponse to type I interferon
B0042742biological_processdefense response to bacterium
B0045071biological_processnegative regulation of viral genome replication
B0045087biological_processinnate immune response
B0045648biological_processpositive regulation of erythrocyte differentiation
B0051240biological_processpositive regulation of multicellular organismal process
B0051607biological_processdefense response to virus
B0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
B0070585biological_processprotein localization to mitochondrion
C0002682biological_processregulation of immune system process
C0003735molecular_functionstructural constituent of ribosome
C0005178molecular_functionintegrin binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0007229biological_processintegrin-mediated signaling pathway
C0009615biological_processresponse to virus
C0009617biological_processresponse to bacterium
C0019941biological_processmodification-dependent protein catabolic process
C0022626cellular_componentcytosolic ribosome
C0030501biological_processpositive regulation of bone mineralization
C0031386molecular_functionprotein tag activity
C0031397biological_processnegative regulation of protein ubiquitination
C0032020biological_processISG15-protein conjugation
C0032461biological_processpositive regulation of protein oligomerization
C0032649biological_processregulation of type II interferon production
C0032728biological_processpositive regulation of interferon-beta production
C0032729biological_processpositive regulation of type II interferon production
C0032733biological_processpositive regulation of interleukin-10 production
C0034340biological_processresponse to type I interferon
C0042742biological_processdefense response to bacterium
C0045071biological_processnegative regulation of viral genome replication
C0045087biological_processinnate immune response
C0045648biological_processpositive regulation of erythrocyte differentiation
C0051240biological_processpositive regulation of multicellular organismal process
C0051607biological_processdefense response to virus
C0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
C0070585biological_processprotein localization to mitochondrion
D0002682biological_processregulation of immune system process
D0003735molecular_functionstructural constituent of ribosome
D0005178molecular_functionintegrin binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0007229biological_processintegrin-mediated signaling pathway
D0009615biological_processresponse to virus
D0009617biological_processresponse to bacterium
D0019941biological_processmodification-dependent protein catabolic process
D0022626cellular_componentcytosolic ribosome
D0030501biological_processpositive regulation of bone mineralization
D0031386molecular_functionprotein tag activity
D0031397biological_processnegative regulation of protein ubiquitination
D0032020biological_processISG15-protein conjugation
D0032461biological_processpositive regulation of protein oligomerization
D0032649biological_processregulation of type II interferon production
D0032728biological_processpositive regulation of interferon-beta production
D0032729biological_processpositive regulation of type II interferon production
D0032733biological_processpositive regulation of interleukin-10 production
D0034340biological_processresponse to type I interferon
D0042742biological_processdefense response to bacterium
D0045071biological_processnegative regulation of viral genome replication
D0045087biological_processinnate immune response
D0045648biological_processpositive regulation of erythrocyte differentiation
D0051240biological_processpositive regulation of multicellular organismal process
D0051607biological_processdefense response to virus
D0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
D0070585biological_processprotein localization to mitochondrion
E0002682biological_processregulation of immune system process
E0003735molecular_functionstructural constituent of ribosome
E0005178molecular_functionintegrin binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0007229biological_processintegrin-mediated signaling pathway
E0009615biological_processresponse to virus
E0009617biological_processresponse to bacterium
E0019941biological_processmodification-dependent protein catabolic process
E0022626cellular_componentcytosolic ribosome
E0030501biological_processpositive regulation of bone mineralization
E0031386molecular_functionprotein tag activity
E0031397biological_processnegative regulation of protein ubiquitination
E0032020biological_processISG15-protein conjugation
E0032461biological_processpositive regulation of protein oligomerization
E0032649biological_processregulation of type II interferon production
E0032728biological_processpositive regulation of interferon-beta production
E0032729biological_processpositive regulation of type II interferon production
E0032733biological_processpositive regulation of interleukin-10 production
E0034340biological_processresponse to type I interferon
E0042742biological_processdefense response to bacterium
E0045071biological_processnegative regulation of viral genome replication
E0045087biological_processinnate immune response
E0045648biological_processpositive regulation of erythrocyte differentiation
E0051240biological_processpositive regulation of multicellular organismal process
E0051607biological_processdefense response to virus
E0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
E0070585biological_processprotein localization to mitochondrion
F0002682biological_processregulation of immune system process
F0003735molecular_functionstructural constituent of ribosome
F0005178molecular_functionintegrin binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0007229biological_processintegrin-mediated signaling pathway
F0009615biological_processresponse to virus
F0009617biological_processresponse to bacterium
F0019941biological_processmodification-dependent protein catabolic process
F0022626cellular_componentcytosolic ribosome
F0030501biological_processpositive regulation of bone mineralization
F0031386molecular_functionprotein tag activity
F0031397biological_processnegative regulation of protein ubiquitination
F0032020biological_processISG15-protein conjugation
F0032461biological_processpositive regulation of protein oligomerization
F0032649biological_processregulation of type II interferon production
F0032728biological_processpositive regulation of interferon-beta production
F0032729biological_processpositive regulation of type II interferon production
F0032733biological_processpositive regulation of interleukin-10 production
F0034340biological_processresponse to type I interferon
F0042742biological_processdefense response to bacterium
F0045071biological_processnegative regulation of viral genome replication
F0045087biological_processinnate immune response
F0045648biological_processpositive regulation of erythrocyte differentiation
F0051240biological_processpositive regulation of multicellular organismal process
F0051607biological_processdefense response to virus
F0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
F0070585biological_processprotein localization to mitochondrion
G0002682biological_processregulation of immune system process
G0003735molecular_functionstructural constituent of ribosome
G0005178molecular_functionintegrin binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0007229biological_processintegrin-mediated signaling pathway
G0009615biological_processresponse to virus
G0009617biological_processresponse to bacterium
G0019941biological_processmodification-dependent protein catabolic process
G0022626cellular_componentcytosolic ribosome
G0030501biological_processpositive regulation of bone mineralization
G0031386molecular_functionprotein tag activity
G0031397biological_processnegative regulation of protein ubiquitination
G0032020biological_processISG15-protein conjugation
G0032461biological_processpositive regulation of protein oligomerization
G0032649biological_processregulation of type II interferon production
G0032728biological_processpositive regulation of interferon-beta production
G0032729biological_processpositive regulation of type II interferon production
G0032733biological_processpositive regulation of interleukin-10 production
G0034340biological_processresponse to type I interferon
G0042742biological_processdefense response to bacterium
G0045071biological_processnegative regulation of viral genome replication
G0045087biological_processinnate immune response
G0045648biological_processpositive regulation of erythrocyte differentiation
G0051240biological_processpositive regulation of multicellular organismal process
G0051607biological_processdefense response to virus
G0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
G0070585biological_processprotein localization to mitochondrion
H0002682biological_processregulation of immune system process
H0003735molecular_functionstructural constituent of ribosome
H0005178molecular_functionintegrin binding
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0007229biological_processintegrin-mediated signaling pathway
H0009615biological_processresponse to virus
H0009617biological_processresponse to bacterium
H0019941biological_processmodification-dependent protein catabolic process
H0022626cellular_componentcytosolic ribosome
H0030501biological_processpositive regulation of bone mineralization
H0031386molecular_functionprotein tag activity
H0031397biological_processnegative regulation of protein ubiquitination
H0032020biological_processISG15-protein conjugation
H0032461biological_processpositive regulation of protein oligomerization
H0032649biological_processregulation of type II interferon production
H0032728biological_processpositive regulation of interferon-beta production
H0032729biological_processpositive regulation of type II interferon production
H0032733biological_processpositive regulation of interleukin-10 production
H0034340biological_processresponse to type I interferon
H0042742biological_processdefense response to bacterium
H0045071biological_processnegative regulation of viral genome replication
H0045087biological_processinnate immune response
H0045648biological_processpositive regulation of erythrocyte differentiation
H0051240biological_processpositive regulation of multicellular organismal process
H0051607biological_processdefense response to virus
H0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
H0070585biological_processprotein localization to mitochondrion
I0002682biological_processregulation of immune system process
I0003735molecular_functionstructural constituent of ribosome
I0005178molecular_functionintegrin binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0007229biological_processintegrin-mediated signaling pathway
I0009615biological_processresponse to virus
I0009617biological_processresponse to bacterium
I0019941biological_processmodification-dependent protein catabolic process
I0022626cellular_componentcytosolic ribosome
I0030501biological_processpositive regulation of bone mineralization
I0031386molecular_functionprotein tag activity
I0031397biological_processnegative regulation of protein ubiquitination
I0032020biological_processISG15-protein conjugation
I0032461biological_processpositive regulation of protein oligomerization
I0032649biological_processregulation of type II interferon production
I0032728biological_processpositive regulation of interferon-beta production
I0032729biological_processpositive regulation of type II interferon production
I0032733biological_processpositive regulation of interleukin-10 production
I0034340biological_processresponse to type I interferon
I0042742biological_processdefense response to bacterium
I0045071biological_processnegative regulation of viral genome replication
I0045087biological_processinnate immune response
I0045648biological_processpositive regulation of erythrocyte differentiation
I0051240biological_processpositive regulation of multicellular organismal process
I0051607biological_processdefense response to virus
I0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
I0070585biological_processprotein localization to mitochondrion
J0002682biological_processregulation of immune system process
J0003735molecular_functionstructural constituent of ribosome
J0005178molecular_functionintegrin binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0007229biological_processintegrin-mediated signaling pathway
J0009615biological_processresponse to virus
J0009617biological_processresponse to bacterium
J0019941biological_processmodification-dependent protein catabolic process
J0022626cellular_componentcytosolic ribosome
J0030501biological_processpositive regulation of bone mineralization
J0031386molecular_functionprotein tag activity
J0031397biological_processnegative regulation of protein ubiquitination
J0032020biological_processISG15-protein conjugation
J0032461biological_processpositive regulation of protein oligomerization
J0032649biological_processregulation of type II interferon production
J0032728biological_processpositive regulation of interferon-beta production
J0032729biological_processpositive regulation of type II interferon production
J0032733biological_processpositive regulation of interleukin-10 production
J0034340biological_processresponse to type I interferon
J0042742biological_processdefense response to bacterium
J0045071biological_processnegative regulation of viral genome replication
J0045087biological_processinnate immune response
J0045648biological_processpositive regulation of erythrocyte differentiation
J0051240biological_processpositive regulation of multicellular organismal process
J0051607biological_processdefense response to virus
J0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
J0070585biological_processprotein localization to mitochondrion
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues444
DetailsDomain: {"description":"Ubiquitin-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues20
DetailsModified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"18606809","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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