5TJY

Structure of 4-Hydroxy-tetrahydrodipicolinate Reductase from Mycobacterium tuberculosis with 2,6 Pyridine Dicarboxylic Acid and NADH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase
A	0009085	biological_process	lysine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0016491	molecular_function	oxidoreductase activity
A	0016726	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
A	0019877	biological_process	diaminopimelate biosynthetic process
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue PDC A 301

Chain	Residue
A	THR77
A	NAI302
A	HOH413
A	HOH420
A	PRO103
A	ASN104
A	HIS133
A	LYS136
A	SER141
A	GLY142
A	THR143
A	ALA192

---

site_id	AC2
Number of Residues	26
Details	binding site for residue NAI A 302

Chain	Residue
A	GLY7
A	LYS9
A	GLY10
A	LYS11
A	VAL12
A	ASP33
A	ALA34
A	PHE52
A	THR53
A	VAL57
A	GLY75
A	THR76
A	THR77
A	ALA102
A	PRO103
A	ASN104
A	PHE105
A	LYS136
A	ASP138
A	PHE217
A	PDC301
A	HOH404
A	HOH410
A	HOH413
A	HOH420
A	HOH429

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 303

Chain	Residue
A	GLY78
A	ALA139
A	PRO140
A	HOH401

---

site_id	AC4
Number of Residues	8
Details	binding site for residue BEZ A 304

Chain	Residue
A	MET59
A	MET59
A	ARG83
A	ARG83
A	IMD305
A	IMD305
A	HOH418
A	HOH418

---

site_id	AC5
Number of Residues	9
Details	binding site for residue IMD A 305

Chain	Residue
A	MET59
A	MET59
A	GLY60
A	GLY60
A	GLU63
A	GLU63
A	TRP90
A	BEZ304
A	BEZ304

---

site_id	AC6
Number of Residues	6
Details	binding site for residue PG4 A 306

Chain	Residue
A	GLU195
A	GLU195
A	THR206
A	ARG208
A	ASP210
A	ASP210

---

site_id	AC7
Number of Residues	5
Details	binding site for residue NA A 307

Chain	Residue
A	VAL20
A	ALA21
A	ALA23
A	LEU26
A	HOH491

---

site_id	AC8
Number of Residues	1
Details	binding site for residue EDO A 308

Chain	Residue
A	PHE122

---

site_id	AC9
Number of Residues	1
Details	binding site for residue EDO A 309

Chain	Residue
A	ASN45

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 310

Chain	Residue
A	ARG173
A	GLY174
A	ASP176
A	PRO181

---

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO A 312

Chain	Residue
A	ASP176
A	ASP178
A	GLY179

---

site_id	AD3
Number of Residues	2
Details	binding site for residue EDO A 313

Chain	Residue
A	ASN161
A	ASP163

---

site_id	AD4
Number of Residues	4
Details	binding site for residue CL A 314

Chain	Residue
A	GLY237
A	LEU238
A	GLU239
A	HOH433

---

Functional Information from PROSITE/UniProt

site_id	PS01298
Number of Residues	18
Details	DAPB Dihydrodipicolinate reductase signature. EViElHhphKaDapSGTA

Chain	Residue	Details
A	GLU127-ALA144

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00102","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00102","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00102","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---