Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5TJH

hUGDH A136M Substitution

Functional Information from GO Data
ChainGOidnamespacecontents
A0001702biological_processgastrulation with mouth forming second
A0003824molecular_functioncatalytic activity
A0003979molecular_functionUDP-glucose 6-dehydrogenase activity
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005829cellular_componentcytosol
A0006024biological_processglycosaminoglycan biosynthetic process
A0006065biological_processUDP-glucuronate biosynthetic process
A0015012biological_processheparan sulfate proteoglycan biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0034214biological_processprotein hexamerization
A0042802molecular_functionidentical protein binding
A0048666biological_processneuron development
A0050650biological_processchondroitin sulfate proteoglycan biosynthetic process
A0051287molecular_functionNAD binding
A0070062cellular_componentextracellular exosome
B0001702biological_processgastrulation with mouth forming second
B0003824molecular_functioncatalytic activity
B0003979molecular_functionUDP-glucose 6-dehydrogenase activity
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005829cellular_componentcytosol
B0006024biological_processglycosaminoglycan biosynthetic process
B0006065biological_processUDP-glucuronate biosynthetic process
B0015012biological_processheparan sulfate proteoglycan biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0034214biological_processprotein hexamerization
B0042802molecular_functionidentical protein binding
B0048666biological_processneuron development
B0050650biological_processchondroitin sulfate proteoglycan biosynthetic process
B0051287molecular_functionNAD binding
B0070062cellular_componentextracellular exosome
C0001702biological_processgastrulation with mouth forming second
C0003824molecular_functioncatalytic activity
C0003979molecular_functionUDP-glucose 6-dehydrogenase activity
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005829cellular_componentcytosol
C0006024biological_processglycosaminoglycan biosynthetic process
C0006065biological_processUDP-glucuronate biosynthetic process
C0015012biological_processheparan sulfate proteoglycan biosynthetic process
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0034214biological_processprotein hexamerization
C0042802molecular_functionidentical protein binding
C0048666biological_processneuron development
C0050650biological_processchondroitin sulfate proteoglycan biosynthetic process
C0051287molecular_functionNAD binding
C0070062cellular_componentextracellular exosome
D0001702biological_processgastrulation with mouth forming second
D0003824molecular_functioncatalytic activity
D0003979molecular_functionUDP-glucose 6-dehydrogenase activity
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005829cellular_componentcytosol
D0006024biological_processglycosaminoglycan biosynthetic process
D0006065biological_processUDP-glucuronate biosynthetic process
D0015012biological_processheparan sulfate proteoglycan biosynthetic process
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0034214biological_processprotein hexamerization
D0042802molecular_functionidentical protein binding
D0048666biological_processneuron development
D0050650biological_processchondroitin sulfate proteoglycan biosynthetic process
D0051287molecular_functionNAD binding
D0070062cellular_componentextracellular exosome
E0001702biological_processgastrulation with mouth forming second
E0003824molecular_functioncatalytic activity
E0003979molecular_functionUDP-glucose 6-dehydrogenase activity
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005829cellular_componentcytosol
E0006024biological_processglycosaminoglycan biosynthetic process
E0006065biological_processUDP-glucuronate biosynthetic process
E0015012biological_processheparan sulfate proteoglycan biosynthetic process
E0016491molecular_functionoxidoreductase activity
E0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E0034214biological_processprotein hexamerization
E0042802molecular_functionidentical protein binding
E0048666biological_processneuron development
E0050650biological_processchondroitin sulfate proteoglycan biosynthetic process
E0051287molecular_functionNAD binding
E0070062cellular_componentextracellular exosome
F0001702biological_processgastrulation with mouth forming second
F0003824molecular_functioncatalytic activity
F0003979molecular_functionUDP-glucose 6-dehydrogenase activity
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005829cellular_componentcytosol
F0006024biological_processglycosaminoglycan biosynthetic process
F0006065biological_processUDP-glucuronate biosynthetic process
F0015012biological_processheparan sulfate proteoglycan biosynthetic process
F0016491molecular_functionoxidoreductase activity
F0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F0034214biological_processprotein hexamerization
F0042802molecular_functionidentical protein binding
F0048666biological_processneuron development
F0050650biological_processchondroitin sulfate proteoglycan biosynthetic process
F0051287molecular_functionNAD binding
F0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue POP A 501
ChainResidue
APHE272
AGLY273
APHE277
APHE338
AARG442
AHOH656
site_idAC2
Number of Residues9
Detailsbinding site for residue POP B 501
ChainResidue
BPHE277
BPHE338
BLYS339
BARG442
BHOH601
BHOH603
BGLY271
BPHE272
BGLY273
site_idAC3
Number of Residues1
Detailsbinding site for residue CL B 502
ChainResidue
BSER316
site_idAC4
Number of Residues17
Detailsbinding site for residue UPG C 501
ChainResidue
CPHE162
CLYS220
CASN224
CILE231
CPHE265
CLYS267
CSER269
CPHE272
CGLY273
CCYS276
CPHE277
CPHE338
CLYS339
CARG442
CHOH621
CHOH710
DARG260
site_idAC5
Number of Residues8
Detailsbinding site for residue POP D 501
ChainResidue
DGLY271
DPHE272
DGLY273
DPHE277
DPHE338
DARG442
DHOH602
DHOH678
site_idAC6
Number of Residues3
Detailsbinding site for residue CL D 502
ChainResidue
DTRP417
DASP418
DMET419
site_idAC7
Number of Residues6
Detailsbinding site for residue POP E 501
ChainResidue
EPHE272
EGLY273
EPHE338
ELYS339
EHOH624
EHOH667
site_idAC8
Number of Residues8
Detailsbinding site for residue POP F 501
ChainResidue
FGLY271
FPHE272
FGLY273
FPHE277
FPHE338
FHOH601
FHOH602
FHOH701
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues132
DetailsRegion: {"description":"Disordered","evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues36
DetailsRegion: {"description":"Allosteric switch region","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21961565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30457329","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues24
DetailsRegion: {"description":"Important for formation of active hexamer structure","evidences":[{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsActive site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues84
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues90
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TJH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KHU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

245663

PDB entries from 2025-12-03

PDB statisticsPDBj update infoContact PDBjnumon