Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5TJ5

Atomic model for the membrane-embedded motor of a eukaryotic V-ATPase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000139	cellular_component	Golgi membrane
B	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
B	0000329	cellular_component	fungal-type vacuole membrane
B	0005773	cellular_component	vacuole
B	0005774	cellular_component	vacuolar membrane
B	0007035	biological_process	vacuolar acidification
B	0008553	molecular_function	P-type proton-exporting transporter activity
B	0015078	molecular_function	proton transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
B	0033176	cellular_component	proton-transporting V-type ATPase complex
B	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
B	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	0048388	biological_process	endosomal lumen acidification
B	0061795	biological_process	Golgi lumen acidification
B	1902600	biological_process	proton transmembrane transport
D	0000139	cellular_component	Golgi membrane
D	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
D	0000324	cellular_component	fungal-type vacuole
D	0000329	cellular_component	fungal-type vacuole membrane
D	0005773	cellular_component	vacuole
D	0005774	cellular_component	vacuolar membrane
D	0007035	biological_process	vacuolar acidification
D	0015078	molecular_function	proton transmembrane transporter activity
D	0016020	cellular_component	membrane
D	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
D	0033176	cellular_component	proton-transporting V-type ATPase complex
D	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
D	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	0048388	biological_process	endosomal lumen acidification
D	0061795	biological_process	Golgi lumen acidification
D	0071944	cellular_component	cell periphery
D	1902600	biological_process	proton transmembrane transport
E	0000139	cellular_component	Golgi membrane
E	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
E	0000329	cellular_component	fungal-type vacuole membrane
E	0005773	cellular_component	vacuole
E	0005774	cellular_component	vacuolar membrane
E	0006623	biological_process	protein targeting to vacuole
E	0006878	biological_process	intracellular copper ion homeostasis
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006897	biological_process	endocytosis
E	0007033	biological_process	vacuole organization
E	0007035	biological_process	vacuolar acidification
E	0015078	molecular_function	proton transmembrane transporter activity
E	0016020	cellular_component	membrane
E	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
E	0033176	cellular_component	proton-transporting V-type ATPase complex
E	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
E	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	0048388	biological_process	endosomal lumen acidification
E	0061795	biological_process	Golgi lumen acidification
E	1902600	biological_process	proton transmembrane transport
F	0000139	cellular_component	Golgi membrane
F	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
F	0000329	cellular_component	fungal-type vacuole membrane
F	0005773	cellular_component	vacuole
F	0005774	cellular_component	vacuolar membrane
F	0006623	biological_process	protein targeting to vacuole
F	0006878	biological_process	intracellular copper ion homeostasis
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006897	biological_process	endocytosis
F	0007033	biological_process	vacuole organization
F	0007035	biological_process	vacuolar acidification
F	0015078	molecular_function	proton transmembrane transporter activity
F	0016020	cellular_component	membrane
F	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
F	0033176	cellular_component	proton-transporting V-type ATPase complex
F	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
F	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	0048388	biological_process	endosomal lumen acidification
F	0061795	biological_process	Golgi lumen acidification
F	1902600	biological_process	proton transmembrane transport
G	0000139	cellular_component	Golgi membrane
G	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
G	0000329	cellular_component	fungal-type vacuole membrane
G	0005773	cellular_component	vacuole
G	0005774	cellular_component	vacuolar membrane
G	0006623	biological_process	protein targeting to vacuole
G	0006878	biological_process	intracellular copper ion homeostasis
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006897	biological_process	endocytosis
G	0007033	biological_process	vacuole organization
G	0007035	biological_process	vacuolar acidification
G	0015078	molecular_function	proton transmembrane transporter activity
G	0016020	cellular_component	membrane
G	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
G	0033176	cellular_component	proton-transporting V-type ATPase complex
G	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
G	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	0048388	biological_process	endosomal lumen acidification
G	0061795	biological_process	Golgi lumen acidification
G	1902600	biological_process	proton transmembrane transport
H	0000139	cellular_component	Golgi membrane
H	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
H	0000329	cellular_component	fungal-type vacuole membrane
H	0005773	cellular_component	vacuole
H	0005774	cellular_component	vacuolar membrane
H	0006623	biological_process	protein targeting to vacuole
H	0006878	biological_process	intracellular copper ion homeostasis
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006897	biological_process	endocytosis
H	0007033	biological_process	vacuole organization
H	0007035	biological_process	vacuolar acidification
H	0015078	molecular_function	proton transmembrane transporter activity
H	0016020	cellular_component	membrane
H	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
H	0033176	cellular_component	proton-transporting V-type ATPase complex
H	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
H	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	0048388	biological_process	endosomal lumen acidification
H	0061795	biological_process	Golgi lumen acidification
H	1902600	biological_process	proton transmembrane transport
I	0000139	cellular_component	Golgi membrane
I	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
I	0000329	cellular_component	fungal-type vacuole membrane
I	0005773	cellular_component	vacuole
I	0005774	cellular_component	vacuolar membrane
I	0006623	biological_process	protein targeting to vacuole
I	0006878	biological_process	intracellular copper ion homeostasis
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006897	biological_process	endocytosis
I	0007033	biological_process	vacuole organization
I	0007035	biological_process	vacuolar acidification
I	0015078	molecular_function	proton transmembrane transporter activity
I	0016020	cellular_component	membrane
I	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
I	0033176	cellular_component	proton-transporting V-type ATPase complex
I	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
I	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	0048388	biological_process	endosomal lumen acidification
I	0061795	biological_process	Golgi lumen acidification
I	1902600	biological_process	proton transmembrane transport
J	0000139	cellular_component	Golgi membrane
J	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
J	0000329	cellular_component	fungal-type vacuole membrane
J	0005773	cellular_component	vacuole
J	0005774	cellular_component	vacuolar membrane
J	0006623	biological_process	protein targeting to vacuole
J	0006878	biological_process	intracellular copper ion homeostasis
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006897	biological_process	endocytosis
J	0007033	biological_process	vacuole organization
J	0007035	biological_process	vacuolar acidification
J	0015078	molecular_function	proton transmembrane transporter activity
J	0016020	cellular_component	membrane
J	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
J	0033176	cellular_component	proton-transporting V-type ATPase complex
J	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
J	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	0048388	biological_process	endosomal lumen acidification
J	0061795	biological_process	Golgi lumen acidification
J	1902600	biological_process	proton transmembrane transport
L	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0000139	cellular_component	Golgi membrane
M	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
M	0000329	cellular_component	fungal-type vacuole membrane
M	0005773	cellular_component	vacuole
M	0005774	cellular_component	vacuolar membrane
M	0006623	biological_process	protein targeting to vacuole
M	0006878	biological_process	intracellular copper ion homeostasis
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006897	biological_process	endocytosis
M	0007033	biological_process	vacuole organization
M	0007035	biological_process	vacuolar acidification
M	0015078	molecular_function	proton transmembrane transporter activity
M	0016020	cellular_component	membrane
M	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
M	0033176	cellular_component	proton-transporting V-type ATPase complex
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	0048388	biological_process	endosomal lumen acidification
M	0061795	biological_process	Golgi lumen acidification
M	1902600	biological_process	proton transmembrane transport
N	0000139	cellular_component	Golgi membrane
N	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
N	0000329	cellular_component	fungal-type vacuole membrane
N	0005773	cellular_component	vacuole
N	0005774	cellular_component	vacuolar membrane
N	0006623	biological_process	protein targeting to vacuole
N	0006878	biological_process	intracellular copper ion homeostasis
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006897	biological_process	endocytosis
N	0007033	biological_process	vacuole organization
N	0007035	biological_process	vacuolar acidification
N	0015078	molecular_function	proton transmembrane transporter activity
N	0016020	cellular_component	membrane
N	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
N	0033176	cellular_component	proton-transporting V-type ATPase complex
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	0048388	biological_process	endosomal lumen acidification
N	0061795	biological_process	Golgi lumen acidification
N	1902600	biological_process	proton transmembrane transport
P	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
L	ALA25-SER35
G	ILE54-VAL74
G	LEU91-GLY112
G	LEU125-LEU150
H	ALA9-GLY31
H	ILE54-VAL74
H	LEU91-GLY112
H	LEU125-LEU150
I	ALA9-GLY31
I	ILE54-VAL74
I	LEU91-GLY112
E	ILE54-VAL74
I	LEU125-LEU150
J	ALA9-GLY31
J	ILE54-VAL74
J	LEU91-GLY112
J	LEU125-LEU150
M	ALA9-GLY31
M	ILE54-VAL74
M	LEU91-GLY112
M	LEU125-LEU150
N	ALA9-GLY31
E	LEU91-GLY112
N	ILE54-VAL74
N	LEU91-GLY112
N	LEU125-LEU150
E	LEU125-LEU150
F	ALA9-GLY31
F	ILE54-VAL74
F	LEU91-GLY112
F	LEU125-LEU150
G	ALA9-GLY31

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
L	THR36-LEU56
I	ASP113-ARG124
J	THR32-ASN53
J	ASP113-ARG124
M	THR32-ASN53
M	ASP113-ARG124
N	THR32-ASN53
N	ASP113-ARG124
E	ASP113-ARG124
F	THR32-ASN53
F	ASP113-ARG124
G	THR32-ASN53
G	ASP113-ARG124
H	THR32-ASN53
H	ASP113-ARG124
I	THR32-ASN53

site_id	SWS_FT_FI3
Number of Residues	120
Details	TOPO_DOM: Vacuolar => ECO:0000255

Chain	Residue	Details
E	CYS75-GLN90
F	CYS75-GLN90
G	CYS75-GLN90
H	CYS75-GLN90
I	CYS75-GLN90
J	CYS75-GLN90
M	CYS75-GLN90
N	CYS75-GLN90

site_id	SWS_FT_FI4
Number of Residues	8
Details	SITE: Essential for proton translocation => ECO:0000269\|PubMed:1825730

Chain	Residue	Details
E	GLU137
F	GLU137
G	GLU137
H	GLU137
I	GLU137
J	GLU137
M	GLU137
N	GLU137

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)