5TDB

Crystal structure of the human UBR-box domain from UBR2 in complex with asymmetrically double methylated arginine peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0071596	biological_process	ubiquitin-dependent protein catabolic process via the N-end rule pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 201

Chain	Residue
A	CYS99
A	CYS124
A	CYS127
A	CYS149

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 202

Chain	Residue
A	CYS127
A	CYS151
A	CYS163
A	HIS166

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site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 203

Chain	Residue
A	CYS115
A	HIS133
A	HIS136
A	CYS112

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site_id	AC4
Number of Residues	2
Details	binding site for residue EDO A 204

Chain	Residue
A	THR154
A	TRP157

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	BINDING: BINDING => ECO:0000269|PubMed:20835242, ECO:0000269|PubMed:28392261, ECO:0007744|PDB:3NY2, ECO:0007744|PDB:3NY3, ECO:0007744|PDB:5TDA, ECO:0007744|PDB:5TDB, ECO:0007744|PDB:5TDD, ECO:0007744|PDB:5UM3

Chain	Residue	Details
A	CYS99
A	CYS163
A	HIS166
A	CYS112
A	CYS115
A	CYS124
A	CYS127
A	HIS133
A	HIS136
A	CYS149
A	CYS151

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:20835242, ECO:0000269|PubMed:28392261, ECO:0007744|PDB:3NY3, ECO:0007744|PDB:5TDA

Chain	Residue	Details
A	PHE148
A	ASP150

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:20835242, ECO:0000269|PubMed:28392261, ECO:0007744|PDB:3NY3

Chain	Residue	Details
A	ASP153

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site_id	SWS_FT_FI4
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:38225265

Chain	Residue	Details
A	LYS158
A	LYS165

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