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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5TBY

HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF OBTAINED BY HOMOLOGY MODELING (USING SWISS-MODEL) OF HUMAN SEQUENCE FROM APHONOPELMA HOMOLOGY MODEL (PDB-3JBH), RIGIDLY FITTED TO HUMAN BETA-CARDIAC NEGATIVELY STAINED THICK FILAMENT 3D-RECONSTRUCTION (EMD-2240)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000146molecular_functionmicrofilament motor activity
A0000166molecular_functionnucleotide binding
A0001725cellular_componentstress fiber
A0002026biological_processregulation of the force of heart contraction
A0002027biological_processregulation of heart rate
A0003009biological_processskeletal muscle contraction
A0003774molecular_functioncytoskeletal motor activity
A0003779molecular_functionactin binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005859cellular_componentmuscle myosin complex
A0006936biological_processmuscle contraction
A0006941biological_processstriated muscle contraction
A0007512biological_processadult heart development
A0014728biological_processregulation of the force of skeletal muscle contraction
A0014883biological_processtransition between fast and slow fiber
A0014898biological_processcardiac muscle hypertrophy in response to stress
A0016459cellular_componentmyosin complex
A0016460cellular_componentmyosin II complex
A0030016cellular_componentmyofibril
A0030017cellular_componentsarcomere
A0030018cellular_componentZ disc
A0030049biological_processmuscle filament sliding
A0031449biological_processregulation of slow-twitch skeletal muscle fiber contraction
A0032982cellular_componentmyosin filament
A0046034biological_processATP metabolic process
A0051015molecular_functionactin filament binding
A0055010biological_processventricular cardiac muscle tissue morphogenesis
A0060048biological_processcardiac muscle contraction
A0099512cellular_componentsupramolecular fiber
B0000146molecular_functionmicrofilament motor activity
B0000166molecular_functionnucleotide binding
B0001725cellular_componentstress fiber
B0002026biological_processregulation of the force of heart contraction
B0002027biological_processregulation of heart rate
B0003009biological_processskeletal muscle contraction
B0003774molecular_functioncytoskeletal motor activity
B0003779molecular_functionactin binding
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005859cellular_componentmuscle myosin complex
B0006936biological_processmuscle contraction
B0006941biological_processstriated muscle contraction
B0007512biological_processadult heart development
B0014728biological_processregulation of the force of skeletal muscle contraction
B0014883biological_processtransition between fast and slow fiber
B0014898biological_processcardiac muscle hypertrophy in response to stress
B0016459cellular_componentmyosin complex
B0016460cellular_componentmyosin II complex
B0030016cellular_componentmyofibril
B0030017cellular_componentsarcomere
B0030018cellular_componentZ disc
B0030049biological_processmuscle filament sliding
B0031449biological_processregulation of slow-twitch skeletal muscle fiber contraction
B0032982cellular_componentmyosin filament
B0046034biological_processATP metabolic process
B0051015molecular_functionactin filament binding
B0055010biological_processventricular cardiac muscle tissue morphogenesis
B0060048biological_processcardiac muscle contraction
B0099512cellular_componentsupramolecular fiber
C0002026biological_processregulation of the force of heart contraction
C0003774molecular_functioncytoskeletal motor activity
C0003785molecular_functionactin monomer binding
C0005509molecular_functioncalcium ion binding
C0005829cellular_componentcytosol
C0005859cellular_componentmuscle myosin complex
C0006936biological_processmuscle contraction
C0006942biological_processregulation of striated muscle contraction
C0007519biological_processskeletal muscle tissue development
C0008307molecular_functionstructural constituent of muscle
C0016459cellular_componentmyosin complex
C0016460cellular_componentmyosin II complex
C0030017cellular_componentsarcomere
C0031672cellular_componentA band
C0031674cellular_componentI band
C0032038molecular_functionmyosin II heavy chain binding
C0055010biological_processventricular cardiac muscle tissue morphogenesis
C0060048biological_processcardiac muscle contraction
D0002026biological_processregulation of the force of heart contraction
D0003774molecular_functioncytoskeletal motor activity
D0003785molecular_functionactin monomer binding
D0005509molecular_functioncalcium ion binding
D0005829cellular_componentcytosol
D0005859cellular_componentmuscle myosin complex
D0006936biological_processmuscle contraction
D0006942biological_processregulation of striated muscle contraction
D0007519biological_processskeletal muscle tissue development
D0008307molecular_functionstructural constituent of muscle
D0016459cellular_componentmyosin complex
D0016460cellular_componentmyosin II complex
D0030017cellular_componentsarcomere
D0031672cellular_componentA band
D0031674cellular_componentI band
D0032038molecular_functionmyosin II heavy chain binding
D0055010biological_processventricular cardiac muscle tissue morphogenesis
D0060048biological_processcardiac muscle contraction
E0002026biological_processregulation of the force of heart contraction
E0003007biological_processheart morphogenesis
E0003785molecular_functionactin monomer binding
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0006942biological_processregulation of striated muscle contraction
E0007507biological_processheart development
E0008307molecular_functionstructural constituent of muscle
E0009791biological_processpost-embryonic development
E0015629cellular_componentactin cytoskeleton
E0016459cellular_componentmyosin complex
E0030016cellular_componentmyofibril
E0030017cellular_componentsarcomere
E0030308biological_processnegative regulation of cell growth
E0031672cellular_componentA band
E0032036molecular_functionmyosin heavy chain binding
E0042694biological_processmuscle cell fate specification
E0046872molecular_functionmetal ion binding
E0055001biological_processmuscle cell development
E0055003biological_processcardiac myofibril assembly
E0055010biological_processventricular cardiac muscle tissue morphogenesis
E0060047biological_processheart contraction
E0060048biological_processcardiac muscle contraction
E0097512cellular_componentcardiac myofibril
E0098735biological_processpositive regulation of the force of heart contraction
F0002026biological_processregulation of the force of heart contraction
F0003007biological_processheart morphogenesis
F0003785molecular_functionactin monomer binding
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0006942biological_processregulation of striated muscle contraction
F0007507biological_processheart development
F0008307molecular_functionstructural constituent of muscle
F0009791biological_processpost-embryonic development
F0015629cellular_componentactin cytoskeleton
F0016459cellular_componentmyosin complex
F0030016cellular_componentmyofibril
F0030017cellular_componentsarcomere
F0030308biological_processnegative regulation of cell growth
F0031672cellular_componentA band
F0032036molecular_functionmyosin heavy chain binding
F0042694biological_processmuscle cell fate specification
F0046872molecular_functionmetal ion binding
F0055001biological_processmuscle cell development
F0055003biological_processcardiac myofibril assembly
F0055010biological_processventricular cardiac muscle tissue morphogenesis
F0060047biological_processheart contraction
F0060048biological_processcardiac muscle contraction
F0097512cellular_componentcardiac myofibril
F0098735biological_processpositive regulation of the force of heart contraction
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DQNRDGFIDknDL
ChainResidueDetails
EASP37-LEU49
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues98
DetailsDomain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1386
DetailsDomain: {"description":"Myosin motor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00782","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues58
DetailsDomain: {"description":"IQ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues72
DetailsRegion: {"description":"Actin-binding"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues14
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P02563","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues144
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues140
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues134
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P16409","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P09542","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P16409","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P09542","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"Deamidated asparagine","evidences":[{"source":"PubMed","id":"20445002","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by ZIPK/DAPK3","evidences":[{"source":"PubMed","id":"20038585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20445002","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P51667","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P08733","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

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