Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004478 | molecular_function | methionine adenosyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004478 | molecular_function | methionine adenosyltransferase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | ASP276 |
| A | HOH535 |
| A | HOH543 |
| B | 3PO404 |
| B | HOH557 |
| B | HOH578 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue AMP A 402 |
| Chain | Residue |
| A | LYS168 |
| A | SER191 |
| A | THR232 |
| A | ARG234 |
| A | PHE235 |
| A | ASP243 |
| A | POP404 |
| A | HOH502 |
| A | HOH668 |
| A | HOH699 |
| B | GLY120 |
| B | ASP121 |
| B | HOH650 |
| A | HIS15 |
| A | PRO16 |
| A | ASP166 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 403 |
| Chain | Residue |
| A | ASP17 |
| A | LYS250 |
| A | POP404 |
| A | PO4405 |
| A | HOH524 |
| A | HOH656 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | binding site for residue POP A 404 |
| Chain | Residue |
| A | HIS15 |
| A | ASP17 |
| A | LYS168 |
| A | LYS250 |
| A | AMP402 |
| A | MG403 |
| A | PO4405 |
| A | HOH524 |
| A | HOH541 |
| A | HOH596 |
| A | HOH652 |
| A | HOH656 |
| A | HOH683 |
| A | HOH692 |
| A | HOH736 |
| B | ASP121 |
| B | LYS270 |
| B | ASP276 |
| B | MG403 |
| B | HOH595 |
| B | HOH600 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue PO4 A 405 |
| Chain | Residue |
| A | ASP17 |
| A | ARG249 |
| A | LYS250 |
| A | MG403 |
| A | POP404 |
| A | HOH524 |
| A | HOH659 |
| A | HOH736 |
| B | GLY264 |
| B | GLY265 |
| B | ALA266 |
| B | LYS270 |
| B | ASP276 |
| B | MG403 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| B | ASP17 |
| B | LYS250 |
| B | 3PO404 |
| B | HOH528 |
| B | HOH583 |
| site_id | AC7 |
| Number of Residues | 25 |
| Details | binding site for residue SAM B 402 |
| Chain | Residue |
| A | ALA41 |
| A | GLU56 |
| A | GLN99 |
| A | ASP102 |
| A | ILE103 |
| A | GLY120 |
| A | ASP121 |
| A | LYS274 |
| A | ILE307 |
| A | HOH585 |
| A | HOH732 |
| B | HIS15 |
| B | PRO16 |
| B | ASP166 |
| B | LYS168 |
| B | SER191 |
| B | ARG234 |
| B | PHE235 |
| B | ASP243 |
| B | 3PO404 |
| B | HOH535 |
| B | HOH577 |
| B | HOH602 |
| B | HOH620 |
| B | HOH638 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 403 |
| Chain | Residue |
| A | POP404 |
| A | PO4405 |
| A | HOH736 |
| B | ASP276 |
| B | HOH600 |
| site_id | AC9 |
| Number of Residues | 21 |
| Details | binding site for residue 3PO B 404 |
| Chain | Residue |
| A | GLY265 |
| A | ALA266 |
| A | LYS270 |
| A | ASP276 |
| A | MG401 |
| A | HOH543 |
| B | HIS15 |
| B | ASP17 |
| B | LYS168 |
| B | ARG249 |
| B | LYS250 |
| B | MG401 |
| B | SAM402 |
| B | HOH523 |
| B | HOH528 |
| B | HOH535 |
| B | HOH551 |
| B | HOH557 |
| B | HOH583 |
| B | HOH618 |
| A | ASP121 |
Functional Information from PROSITE/UniProt
| site_id | PS00376 |
| Number of Residues | 11 |
| Details | ADOMET_SYNTHASE_1 S-adenosylmethionine synthase signature 1. GAGDQGlmfGY |
| Chain | Residue | Details |
| A | GLY118-TYR128 | |
| site_id | PS00377 |
| Number of Residues | 9 |
| Details | ADOMET_SYNTHASE_2 S-adenosylmethionine synthase signature 2. GGGAFSgKD |
| Chain | Residue | Details |
| A | GLY263-ASP271 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Region: {"description":"Flexible loop","evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00086","evidenceCode":"ECO:0000255"}]} |
