5T5M
TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE FROM METHANOTHERMOBACTER WOLFEII, TRIGONAL FORM AT 2.5 A.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003954 | molecular_function | NADH dehydrogenase activity |
| B | 0015948 | biological_process | methanogenesis |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0018493 | molecular_function | formylmethanofuran dehydrogenase activity |
| B | 0022904 | biological_process | respiratory electron transport chain |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| C | 0015948 | biological_process | methanogenesis |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0018493 | molecular_function | formylmethanofuran dehydrogenase activity |
| C | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| C | 0046914 | molecular_function | transition metal ion binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0043546 | molecular_function | molybdopterin cofactor binding |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0051536 | molecular_function | iron-sulfur cluster binding |
| F | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0051536 | molecular_function | iron-sulfur cluster binding |
| G | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 601 |
| Chain | Residue |
| A | VAL340 |
| A | THR344 |
| A | HOH729 |
| A | HOH738 |
| B | GLU138 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 602 |
| Chain | Residue |
| A | HOH720 |
| A | KCX178 |
| A | HIS231 |
| A | HIS271 |
| A | ZN603 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 603 |
| Chain | Residue |
| A | HIS57 |
| A | HIS59 |
| A | KCX178 |
| A | ASP385 |
| A | ZN602 |
| A | HOH720 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 604 |
| Chain | Residue |
| A | ARG69 |
| A | ARG72 |
| A | SER76 |
| A | HOH726 |
| A | HOH757 |
| B | GLY305 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 605 |
| Chain | Residue |
| A | TRP190 |
| A | GLY191 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 606 |
| Chain | Residue |
| A | LYS77 |
| C | GLU82 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue K B 501 |
| Chain | Residue |
| B | SER40 |
| B | VAL43 |
| D | GLU18 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SF4 B 502 |
| Chain | Residue |
| B | CYS9 |
| B | CYS12 |
| B | CYS16 |
| B | CYS35 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue W B 503 |
| Chain | Residue |
| B | CYS118 |
| B | MGD504 |
| B | MGD505 |
| B | H2S506 |
| site_id | AD1 |
| Number of Residues | 34 |
| Details | binding site for residue MGD B 504 |
| Chain | Residue |
| B | LYS41 |
| B | CYS91 |
| B | THR114 |
| B | VAL117 |
| B | CYS118 |
| B | MET254 |
| B | HIS258 |
| B | HIS290 |
| B | ALA342 |
| B | SER343 |
| B | ASP344 |
| B | HIS348 |
| B | ILE365 |
| B | GLU366 |
| B | PRO367 |
| B | HIS368 |
| B | THR370 |
| B | PRO382 |
| B | ILE384 |
| B | VAL385 |
| B | ASP414 |
| B | W503 |
| B | MGD505 |
| B | H2S506 |
| B | HOH603 |
| B | HOH612 |
| B | HOH623 |
| D | THR7 |
| D | ARG9 |
| D | LYS21 |
| D | MET80 |
| D | ASN85 |
| D | PHE100 |
| D | LYS101 |
| site_id | AD2 |
| Number of Residues | 37 |
| Details | binding site for residue MGD B 505 |
| Chain | Residue |
| D | GLY8 |
| D | ARG9 |
| D | THR10 |
| D | GLN13 |
| D | GLY14 |
| D | ILE17 |
| D | MET80 |
| D | LYS101 |
| D | ASN102 |
| B | PHE11 |
| B | ILE37 |
| B | CYS118 |
| B | GLY150 |
| B | CYS151 |
| B | ASN152 |
| B | HIS155 |
| B | ALA156 |
| B | VAL184 |
| B | ASP185 |
| B | PRO186 |
| B | ARG187 |
| B | THR189 |
| B | PHE203 |
| B | ASP204 |
| B | ASP206 |
| B | GLY253 |
| B | MET254 |
| B | GLY255 |
| B | SER259 |
| B | GLY289 |
| B | HIS290 |
| B | W503 |
| B | MGD504 |
| B | H2S506 |
| B | HOH631 |
| B | HOH637 |
| D | ASN6 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue H2S B 506 |
| Chain | Residue |
| B | THR114 |
| B | CYS118 |
| B | HIS290 |
| B | W503 |
| B | MGD504 |
| B | MGD505 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue MG C 301 |
| Chain | Residue |
| B | ASP128 |
| B | HOH609 |
| B | HOH654 |
| C | SER139 |
| C | TYR140 |
| C | GLY142 |
| C | ASP143 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue GOL D 201 |
| Chain | Residue |
| D | ARG89 |
| D | TYR91 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 F 501 |
| Chain | Residue |
| F | CYS154 |
| F | TYR156 |
| F | CYS157 |
| F | GLY158 |
| F | CYS160 |
| F | CYS204 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue SF4 F 502 |
| Chain | Residue |
| F | CYS164 |
| F | CYS194 |
| F | CYS197 |
| F | GLY198 |
| F | CYS200 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue SF4 F 503 |
| Chain | Residue |
| F | CYS281 |
| F | CYS308 |
| F | CYS311 |
| F | CYS314 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 F 504 |
| Chain | Residue |
| F | CYS271 |
| F | CYS274 |
| F | GLU275 |
| F | CYS277 |
| F | CYS318 |
| F | ILE323 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 F 505 |
| Chain | Residue |
| F | LEU24 |
| F | CYS41 |
| F | CYS71 |
| F | CYS74 |
| F | GLY75 |
| F | CYS77 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 F 506 |
| Chain | Residue |
| F | CYS31 |
| F | CYS34 |
| F | GLY35 |
| F | CYS37 |
| F | CYS81 |
| F | PHE83 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 F 507 |
| Chain | Residue |
| F | CYS125 |
| F | ILE130 |
| F | CYS239 |
| F | VAL240 |
| F | ASN241 |
| F | CYS242 |
| F | GLY243 |
| F | CYS245 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 F 508 |
| Chain | Residue |
| F | CYS115 |
| F | ILE116 |
| F | CYS118 |
| F | LYS119 |
| F | CYS121 |
| F | CYS249 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue SF4 G 200 |
| Chain | Residue |
| G | CYS12 |
| G | HIS13 |
| G | CYS15 |
| G | GLY16 |
| G | CYS18 |
| G | CYS71 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue SF4 G 201 |
| Chain | Residue |
| G | CYS22 |
| G | CYS61 |
| G | CYS64 |
| G | GLY65 |
| G | CYS67 |
Functional Information from PROSITE/UniProt
| site_id | PS00198 |
| Number of Residues | 12 |
| Details | 4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CaVCGlCGeICP |
| Chain | Residue | Details |
| F | CYS31-PRO42 | |
| G | CYS61-PRO72 | |
| F | CYS71-PRO82 | |
| F | CYS115-PRO126 | |
| F | CYS154-PRO165 | |
| F | CYS194-PRO205 | |
| F | CYS239-PRO250 | |
| F | CYS271-PRO282 | |
| F | CYS308-PRO319 | |
| G | CYS12-PRO23 |
