5T1V

Crystal structure of Zika virus NS2B-NS3 protease in apo-form.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005524	molecular_function	ATP binding
A	0044423	cellular_component	virion component
B	0003723	molecular_function	RNA binding
B	0003724	molecular_function	RNA helicase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005524	molecular_function	ATP binding
B	0044423	cellular_component	virion component

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860

Chain	Residue	Details
A	HIS116
A	ASP140
B	HIS116
B	ASP140

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860, ECO:0000269|PubMed:29526431

Chain	Residue	Details
A	SER200
B	SER200

---