5T1J
Crystal Structure of the Tbox DNA binding domain of the transcription factor T-bet
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 370 |
| Details | DNA_BIND: T-box => ECO:0000255|PROSITE-ProRule:PRU00201 |
| Chain | Residue | Details |
| A | LEU141-GLU326 | |
| B | LEU141-GLU326 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Essential for its interaction with RUNX1 and its ability to inhibit RUNX1 transcriptional activity and suppress TH17 lineage development => ECO:0000269|PubMed:21151104 |
| Chain | Residue | Details |
| A | TYR305 | |
| B | TYR305 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphotyrosine; by ABL1 => ECO:0000269|PubMed:21690296 |
| Chain | Residue | Details |
| A | TYR220 | |
| A | TYR266 | |
| A | TYR305 | |
| B | TYR220 | |
| B | TYR266 | |
| B | TYR305 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:28424242 |
| Chain | Residue | Details |
| A | SER225 | |
| B | SER225 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:23616576 |
| Chain | Residue | Details |
| A | THR303 | |
| B | THR303 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23616576 |
| Chain | Residue | Details |
| A | LYS314 | |
| B | LYS314 |
