5SZZ
Novel Structural Insights into GDP-Mediated Regulation of Acyl-CoA Thioesterases
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006637 | biological_process | acyl-CoA metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016790 | molecular_function | thiolester hydrolase activity |
| A | 0052816 | molecular_function | long-chain fatty acyl-CoA hydrolase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006637 | biological_process | acyl-CoA metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016790 | molecular_function | thiolester hydrolase activity |
| B | 0052816 | molecular_function | long-chain fatty acyl-CoA hydrolase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006637 | biological_process | acyl-CoA metabolic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016790 | molecular_function | thiolester hydrolase activity |
| C | 0052816 | molecular_function | long-chain fatty acyl-CoA hydrolase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006637 | biological_process | acyl-CoA metabolic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016790 | molecular_function | thiolester hydrolase activity |
| D | 0052816 | molecular_function | long-chain fatty acyl-CoA hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue GDP A 200 |
| Chain | Residue |
| A | TYR77 |
| A | TYR111 |
| A | ARG134 |
| A | ARG138 |
| A | HOH304 |
| A | HOH305 |
| B | ARG5 |
| A | ALA78 |
| A | ALA79 |
| A | ASN81 |
| A | GLY91 |
| A | ILE92 |
| A | ARG93 |
| A | HIS106 |
| A | SER109 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue COA A 201 |
| Chain | Residue |
| A | VAL55 |
| A | THR56 |
| A | LEU57 |
| A | GLY84 |
| A | ARG85 |
| A | THR86 |
| A | SER87 |
| A | PRO122 |
| A | ARG146 |
| A | SER149 |
| A | HOH328 |
| A | HOH332 |
| A | HOH342 |
| A | HOH344 |
| B | VAL29 |
| B | LEU34 |
| B | PHE64 |
| B | LYS65 |
| B | GLU66 |
| B | PRO67 |
| C | GLU129 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue GDP D 200 |
| Chain | Residue |
| C | ARG5 |
| D | TYR77 |
| D | ALA78 |
| D | ALA79 |
| D | ASN81 |
| D | GLY91 |
| D | ILE92 |
| D | ARG93 |
| D | HIS106 |
| D | SER109 |
| D | TYR111 |
| D | ARG138 |
| D | HOH303 |
| D | HOH343 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | binding site for residue COA D 201 |
| Chain | Residue |
| C | VAL29 |
| C | LEU34 |
| C | PHE64 |
| C | LYS65 |
| C | GLU66 |
| C | PRO67 |
| D | THR56 |
| D | LEU57 |
| D | GLY84 |
| D | ARG85 |
| D | THR86 |
| D | SER87 |
| D | PRO122 |
| D | ARG146 |
| D | SER149 |
| D | LEU150 |
| D | HOH308 |
| D | HOH314 |
| D | HOH320 |
| D | HOH321 |
| D | HOH323 |
| D | HOH325 |
| D | HOH344 |
| D | HOH374 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | binding site for residue GDP C 200 |
| Chain | Residue |
| C | GLU11 |
| C | TYR77 |
| C | ALA78 |
| C | ALA79 |
| C | ASN81 |
| C | GLY91 |
| C | ILE92 |
| C | ARG93 |
| C | SER109 |
| C | TYR111 |
| C | ARG134 |
| C | ARG138 |
| C | LYS141 |
| C | HOH304 |
| C | HOH317 |
| C | HOH351 |
| C | HOH370 |
| D | ARG5 |
| site_id | AC6 |
| Number of Residues | 27 |
| Details | binding site for residue COA C 201 |
| Chain | Residue |
| C | PRO122 |
| C | ARG146 |
| C | SER149 |
| C | LEU150 |
| C | HOH301 |
| C | HOH302 |
| C | HOH318 |
| C | HOH320 |
| C | HOH335 |
| C | HOH336 |
| C | HOH339 |
| C | HOH360 |
| C | HOH371 |
| D | VAL29 |
| D | LEU34 |
| D | PHE64 |
| D | LYS65 |
| D | GLU66 |
| D | PRO67 |
| D | HOH328 |
| C | VAL55 |
| C | THR56 |
| C | LEU57 |
| C | GLY84 |
| C | ARG85 |
| C | THR86 |
| C | SER87 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue GDP B 202 |
| Chain | Residue |
| A | ARG5 |
| B | GLU11 |
| B | TYR77 |
| B | ALA78 |
| B | ALA79 |
| B | ASN81 |
| B | GLY91 |
| B | ILE92 |
| B | ARG93 |
| B | SER109 |
| B | TYR111 |
| B | ARG138 |
| B | HOH302 |
| B | HOH310 |
| B | HOH342 |
| site_id | AC8 |
| Number of Residues | 22 |
| Details | binding site for residue COA B 203 |
| Chain | Residue |
| A | VAL29 |
| A | LEU34 |
| A | PHE64 |
| A | LYS65 |
| A | GLU66 |
| A | PRO67 |
| B | VAL55 |
| B | THR56 |
| B | LEU57 |
| B | GLY84 |
| B | ARG85 |
| B | THR86 |
| B | SER87 |
| B | ARG146 |
| B | SER149 |
| B | HOH301 |
| B | HOH308 |
| B | HOH325 |
| B | HOH334 |
| B | HOH345 |
| B | HOH355 |
| B | HOH359 |
