5SZI

Structure of human Rab8a in complex with the bMERB domain of Mical-cL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005768	cellular_component	endosome
A	0005794	cellular_component	Golgi apparatus
A	0005813	cellular_component	centrosome
A	0005814	cellular_component	centriole
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0005930	cellular_component	axoneme
A	0006887	biological_process	exocytosis
A	0006904	biological_process	vesicle docking involved in exocytosis
A	0006914	biological_process	autophagy
A	0007030	biological_process	Golgi organization
A	0007409	biological_process	axonogenesis
A	0008021	cellular_component	synaptic vesicle
A	0010008	cellular_component	endosome membrane
A	0010506	biological_process	regulation of autophagy
A	0015031	biological_process	protein transport
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0019901	molecular_function	protein kinase binding
A	0030030	biological_process	cell projection organization
A	0030140	cellular_component	trans-Golgi network transport vesicle
A	0030425	cellular_component	dendrite
A	0030496	cellular_component	midbody
A	0030670	cellular_component	phagocytic vesicle membrane
A	0031267	molecular_function	small GTPase binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0031489	molecular_function	myosin V binding
A	0032456	biological_process	endocytic recycling
A	0032588	cellular_component	trans-Golgi network membrane
A	0032869	biological_process	cellular response to insulin stimulus
A	0032880	biological_process	regulation of protein localization
A	0036064	cellular_component	ciliary basal body
A	0043025	cellular_component	neuronal cell body
A	0045202	cellular_component	synapse
A	0045335	cellular_component	phagocytic vesicle
A	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
A	0048210	biological_process	Golgi vesicle fusion to target membrane
A	0051223	biological_process	regulation of protein transport
A	0055037	cellular_component	recycling endosome
A	0055038	cellular_component	recycling endosome membrane
A	0060170	cellular_component	ciliary membrane
A	0060271	biological_process	cilium assembly
A	0061512	biological_process	protein localization to cilium
A	0070062	cellular_component	extracellular exosome
A	0072659	biological_process	protein localization to plasma membrane
A	0097546	cellular_component	ciliary base
A	0097730	cellular_component	non-motile cilium
A	0098887	biological_process	neurotransmitter receptor transport, endosome to postsynaptic membrane
A	0098969	biological_process	neurotransmitter receptor transport to postsynaptic membrane
A	0098978	cellular_component	glutamatergic synapse
A	1990782	molecular_function	protein tyrosine kinase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue GNP A 301

Chain	Residue
A	SER17
A	SER35
A	PHE37
A	SER39
A	THR40
A	GLY66
A	ASN121
A	LYS122
A	ASP124
A	SER151
A	ALA152
A	GLY18
A	LYS153
A	MG302
A	HOH401
A	HOH402
A	VAL19
A	GLY20
A	LYS21
A	THR22
A	CYS23
A	PHE33
A	ASN34

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 302

Chain	Residue
A	THR22
A	THR40
A	GNP301
A	HOH401
A	HOH402

---

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLLiGDSGVGKtcV

Chain	Residue	Details
A	LEU11-VAL24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Motif: {"description":"Switch 1","evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	17
Details	Motif: {"description":"Switch 2","evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21378754","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5SZI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21378754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21378754","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3QBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21378754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by LRRK2","evidences":[{"source":"PubMed","id":"26824392","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29125462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30209220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30398148","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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