Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5SWW

Crystal Structure of Human APOBEC3A complexed with ssDNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000932	cellular_component	P-body
A	0002376	biological_process	immune system process
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004126	molecular_function	cytidine deaminase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0010526	biological_process	transposable element silencing
A	0016554	biological_process	cytidine to uridine editing
A	0016787	molecular_function	hydrolase activity
A	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
A	0044355	biological_process	clearance of foreign intracellular DNA
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus
A	0070383	biological_process	DNA cytosine deamination
B	0000932	cellular_component	P-body
B	0002376	biological_process	immune system process
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0004126	molecular_function	cytidine deaminase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0010526	biological_process	transposable element silencing
B	0016554	biological_process	cytidine to uridine editing
B	0016787	molecular_function	hydrolase activity
B	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
B	0044355	biological_process	clearance of foreign intracellular DNA
B	0045071	biological_process	negative regulation of viral genome replication
B	0045087	biological_process	innate immune response
B	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
B	0046872	molecular_function	metal ion binding
B	0051607	biological_process	defense response to virus
B	0070383	biological_process	DNA cytosine deamination
C	0000932	cellular_component	P-body
C	0002376	biological_process	immune system process
C	0003723	molecular_function	RNA binding
C	0003824	molecular_function	catalytic activity
C	0004126	molecular_function	cytidine deaminase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0010526	biological_process	transposable element silencing
C	0016554	biological_process	cytidine to uridine editing
C	0016787	molecular_function	hydrolase activity
C	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
C	0044355	biological_process	clearance of foreign intracellular DNA
C	0045071	biological_process	negative regulation of viral genome replication
C	0045087	biological_process	innate immune response
C	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
C	0046872	molecular_function	metal ion binding
C	0051607	biological_process	defense response to virus
C	0070383	biological_process	DNA cytosine deamination
D	0000932	cellular_component	P-body
D	0002376	biological_process	immune system process
D	0003723	molecular_function	RNA binding
D	0003824	molecular_function	catalytic activity
D	0004126	molecular_function	cytidine deaminase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0010526	biological_process	transposable element silencing
D	0016554	biological_process	cytidine to uridine editing
D	0016787	molecular_function	hydrolase activity
D	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
D	0044355	biological_process	clearance of foreign intracellular DNA
D	0045071	biological_process	negative regulation of viral genome replication
D	0045087	biological_process	innate immune response
D	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
D	0046872	molecular_function	metal ion binding
D	0051607	biological_process	defense response to virus
D	0070383	biological_process	DNA cytosine deamination

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN A 201

Chain	Residue
A	HIS70
A	CYS101
A	CYS106

site_id	AC2
Number of Residues	3
Details	binding site for residue ZN B 201

Chain	Residue
B	HIS70
B	CYS101
B	CYS106

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL B 202

Chain	Residue
B	TYR35
B	HIS51
B	ARG52

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL B 203

Chain	Residue
B	ARG123
B	GLU157
B	HIS160

site_id	AC5
Number of Residues	3
Details	binding site for residue ZN C 201

Chain	Residue
C	HIS70
C	CYS101
C	CYS106

site_id	AC6
Number of Residues	3
Details	binding site for residue ZN D 201

Chain	Residue
D	HIS70
D	CYS101
D	CYS106

site_id	AC7
Number of Residues	1
Details	binding site for residue GOL F 101

Chain	Residue
F	DA-2

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)