Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | VAL272 |
| A | PRO274 |
| A | TYR277 |
| A | ALA312 |
| A | SER329 |
| A | LYS330 |
| A | HOH523 |
| A | HOH532 |
| A | HOH627 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | PRO228 |
| A | SER297 |
| A | ALA298 |
| A | GLY301 |
| A | ILE302 |
| A | ASN303 |
| A | HOH501 |
| A | HOH561 |
| A | HOH613 |
| A | HOH643 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue ACT A 403 |
| Chain | Residue |
| A | CYS255 |
| A | ASP279 |
| A | GLY281 |
| A | CYS290 |
| A | HOH528 |
| A | HOH568 |
| A | HOH721 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PG4 A 404 |
| Chain | Residue |
| A | ASP15 |
| A | PHE280 |
| A | ILE283 |
| A | NA405 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue NA A 405 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue R9J A 406 |
| Chain | Residue |
| A | TYR79 |
| A | ASP81 |
| A | SER115 |
| A | PHE116 |
| A | ASP119 |
| A | GLY221 |
| A | DMS409 |
| A | HOH527 |
| A | HOH600 |
| A | HOH651 |
| A | HOH679 |
| A | HOH718 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue R9J A 407 |
| Chain | Residue |
| A | LYS210 |
| A | THR212 |
| A | SER213 |
| A | THR230 |
| A | VAL231 |
| A | HOH742 |
| A | HOH756 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 408 |
| Chain | Residue |
| A | ASP81 |
| A | GLY82 |
| A | SER83 |
| A | SER113 |
| A | SER114 |
| A | SER115 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue DMS A 409 |
| Chain | Residue |
| A | ASP81 |
| A | GLY221 |
| A | THR222 |
| A | THR223 |
| A | R9J406 |
| A | HOH571 |
| A | HOH679 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 410 |
| Chain | Residue |
| A | VAL204 |
| A | GLY205 |
| A | SER206 |
| A | GLY207 |
| A | GLN238 |
| A | HOH518 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 411 |
| Chain | Residue |
| A | SER46 |
| A | GLU47 |
| A | THR48 |
| A | THR49 |
| A | ALA50 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 412 |
| Chain | Residue |
| A | SER71 |
| A | GLY72 |
| A | ALA73 |
| A | THR74 |
| A | GLY181 |
| A | SER182 |
| A | HOH730 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 413 |
| Chain | Residue |
| A | ALA237 |
| A | GLN238 |
| A | HOH697 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 414 |
| Chain | Residue |
| A | ILE183 |
| A | THR184 |
| A | TYR185 |
| A | ILE283 |
| A | SER287 |
| A | SER288 |
| A | SER289 |
| A | HOH502 |
| A | HOH542 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 415 |
| Chain | Residue |
| A | HOH503 |
| A | TYR202 |
| A | ALA203 |
| A | VAL204 |
| A | GLY207 |
| A | THR208 |
| A | LYS210 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LDFDTGSSDLWV |
| Chain | Residue | Details |
| A | LEU32-VAL43 | |
| A | GLY216-LEU227 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 311 |
| Details | Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {} |
