5QIR
Covalent fragment group deposition -- Crystal Structure of OUTB2 in complex with PCM-0102305
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0016579 | biological_process | protein deubiquitination |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0035871 | biological_process | protein K11-linked deubiquitination |
| A | 0043130 | molecular_function | ubiquitin binding |
| A | 0070536 | biological_process | protein K63-linked deubiquitination |
| A | 0071108 | biological_process | protein K48-linked deubiquitination |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue J5D A 301 |
| Chain | Residue |
| A | ASP48 |
| A | ARG49 |
| A | ASN50 |
| A | CYS51 |
| A | GLU174 |
| A | THR222 |
| A | SER223 |
| A | HIS224 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 302 |
| Chain | Residue |
| A | ALA202 |
| A | HOH404 |
| A | HOH415 |
| A | ASP200 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | ARG38 |
| A | GLN192 |
| A | TYR217 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | PHE6 |
| A | ASN7 |
| A | LEU8 |
| A | SER10 |
| A | LYS44 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 305 |
| Chain | Residue |
| A | LYS12 |
| A | CYS13 |
| A | ASP14 |
| A | THR40 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 306 |
| Chain | Residue |
| A | ASN100 |
| A | HOH436 |
| A | HOH485 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 307 |
| Chain | Residue |
| A | ALA88 |
| A | GLY89 |
| A | PHE90 |
| A | ARG144 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"15258613","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"12704427","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15258613","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required to orient and stabilize the active site H-224","evidences":[{"source":"PubMed","id":"15258613","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
