Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 801 |
| Chain | Residue |
| A | GLN19 |
| A | HOH1068 |
| A | GLY23 |
| A | ALA24 |
| A | SER25 |
| A | ASN163 |
| A | HIS164 |
| A | BJS802 |
| A | HOH958 |
| A | HOH971 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue BJS A 802 |
| Chain | Residue |
| A | PHE70 |
| A | THR73 |
| A | ALA140 |
| A | ARG141 |
| A | ASN161 |
| A | VAL162 |
| A | ASN163 |
| A | HIS164 |
| A | GLY165 |
| A | PHE211 |
| A | SO4801 |
| A | HOH901 |
| A | HOH978 |
| C | LYS41 |
| C | THR42 |
| D | TYR118 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 B 801 |
| Chain | Residue |
| B | GLN19 |
| B | GLY23 |
| B | ALA24 |
| B | SER25 |
| B | ASN163 |
| B | HIS164 |
| B | BJS803 |
| B | HOH906 |
| B | HOH911 |
| B | HOH982 |
| B | HOH1009 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 802 |
| Chain | Residue |
| B | LEU38 |
| B | THR42 |
| B | ALA108 |
| B | THR109 |
| B | ILE217 |
| D | ARG141 |
| D | PRO143 |
| D | PHE146 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | binding site for residue BJS B 803 |
| Chain | Residue |
| B | PHE70 |
| B | THR73 |
| B | ALA140 |
| B | ARG141 |
| B | ASN161 |
| B | VAL162 |
| B | ASN163 |
| B | HIS164 |
| B | GLY165 |
| B | PHE211 |
| B | SO4801 |
| B | HOH913 |
| B | HOH914 |
| B | HOH959 |
| B | HOH1031 |
| C | TYR118 |
| D | LYS41 |
| D | THR42 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 C 801 |
| Chain | Residue |
| C | GLN19 |
| C | GLY23 |
| C | ALA24 |
| C | SER25 |
| C | ASN163 |
| C | HIS164 |
| C | BJS802 |
| C | HOH911 |
| C | HOH992 |
| C | HOH1019 |
| C | HOH1023 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | binding site for residue BJS C 802 |
| Chain | Residue |
| A | LYS41 |
| A | THR42 |
| B | TYR118 |
| C | PHE70 |
| C | THR73 |
| C | ALA140 |
| C | ARG141 |
| C | ASN161 |
| C | VAL162 |
| C | ASN163 |
| C | HIS164 |
| C | GLY165 |
| C | PHE211 |
| C | SO4801 |
| C | HOH914 |
| C | HOH930 |
| C | HOH1021 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 D 801 |
| Chain | Residue |
| D | HOH918 |
| D | HOH935 |
| D | GLN19 |
| D | GLY23 |
| D | ALA24 |
| D | SER25 |
| D | ASN163 |
| D | HIS164 |
| D | BJS803 |
| D | HOH907 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 802 |
| Chain | Residue |
| B | ARG141 |
| B | PRO143 |
| B | PHE146 |
| D | LEU38 |
| D | THR42 |
| D | ALA108 |
| D | THR109 |
| D | ILE217 |
| site_id | AD1 |
| Number of Residues | 18 |
| Details | binding site for residue BJS D 803 |
| Chain | Residue |
| A | TYR118 |
| B | LYS41 |
| B | THR42 |
| D | PHE70 |
| D | THR73 |
| D | ALA140 |
| D | ARG141 |
| D | ASN161 |
| D | VAL162 |
| D | ASN163 |
| D | HIS164 |
| D | GLY165 |
| D | PHE211 |
| D | SO4801 |
| D | HOH901 |
| D | HOH938 |
| D | HOH1003 |
| D | HOH1006 |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VNHGVLVVGYG |
| Chain | Residue | Details |
| A | VAL162-GLY172 | |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWghnFGeeGYIrM |
| Chain | Residue | Details |
| A | TYR179-MET198 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | SER25 | |
| D | SER25 | |
| D | HIS164 | |
| D | ASN184 | |
| A | HIS164 | |
| A | ASN184 | |
| B | SER25 | |
| B | HIS164 | |
| B | ASN184 | |
| C | SER25 | |
| C | HIS164 | |
| C | ASN184 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 814 |
| Chain | Residue | Details |
| A | GLN19 | electrostatic stabiliser |
| A | SER25 | nucleofuge, nucleophile, proton acceptor, proton donor |
| A | HIS164 | proton acceptor, proton donor |
| A | ASN184 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 814 |
| Chain | Residue | Details |
| B | GLN19 | electrostatic stabiliser |
| B | SER25 | nucleofuge, nucleophile, proton acceptor, proton donor |
| B | HIS164 | proton acceptor, proton donor |
| B | ASN184 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 814 |
| Chain | Residue | Details |
| C | GLN19 | electrostatic stabiliser |
| C | SER25 | nucleofuge, nucleophile, proton acceptor, proton donor |
| C | HIS164 | proton acceptor, proton donor |
| C | ASN184 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 814 |
| Chain | Residue | Details |
| D | GLN19 | electrostatic stabiliser |
| D | SER25 | nucleofuge, nucleophile, proton acceptor, proton donor |
| D | HIS164 | proton acceptor, proton donor |
| D | ASN184 | electrostatic stabiliser |
