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5Q0X

Ligand binding to FARNESOID-X-RECEPTOR

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006355biological_processregulation of DNA-templated transcription
A0032052molecular_functionbile acid binding
A0038183biological_processbile acid signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue 643 A 501
ChainResidue
AMET269
ATYR373
APHE288
ALEU291
AMET294
AALA295
APHE333
AARG335
ASER336
AMET369

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PDB","id":"6HL1","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by PKC/PRKCZ","evidences":[{"source":"PubMed","id":"18668687","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"23546875","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsMotif: {"description":"LXXLL motif 5"}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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