5Q0M

Ligand binding to FARNESOID-X-RECEPTOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032052	molecular_function	bile acid binding
A	0038183	biological_process	bile acid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 9L1 A 501

Chain	Residue
A	MET269
A	ILE339
A	ILE361
A	TYR365
A	TYR373
A	HIS451
A	THR274
A	PHE288
A	LEU291
A	THR292
A	MET294
A	HIS298
A	MET332
A	ARG335

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0007744|PDB:6HL1

Chain	Residue	Details
A	ARG335
A	TYR365
A	TYR373
A	HIS451

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687

Chain	Residue	Details
A	THR446

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875

Chain	Residue	Details
A	LYS279

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