5PZW

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(3-chlorophenyl)sulfonyl-3-[5-[(3-chlorophenyl)sulfonylcarbamoylamino]pentyl]urea

?

Functional Information from GO Data

ChainGOidnamespacecontents
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC121binding site for residue 94J A 401
ChainResidue
AVAL17
AMET18
AGLY21
AALA24
AGLY26
ATHR27
AGLY28
AGLU29
ALEU30
ATHR31
AAMZ402
CVAL17
CMET18
CGLY21
CALA24
CGLY26
CTHR27
CGLY28
CGLU29
CLEU30
CTHR31

AC224binding site for residue AMZ A 402
ChainResidue
AVAL17
AGLU20
ATHR27
AGLU29
ALEU30
ATHR31
ALYS112
ATYR113
AARG140
A94J401
AHOH653
CVAL17
CGLU20
CGLY21
CGLY26
CTHR27
CGLY28
CGLU29
CLEU30
CTHR31
CLYS112
CTYR113
CVAL160
CMET177

AC323binding site for residue 94J B 401
ChainResidue
BVAL17
BMET18
BGLY21
BARG22
BALA24
BGLY26
BTHR27
BGLY28
BGLU29
BLEU30
BTHR31
DVAL17
DMET18
DGLY21
DARG22
DALA24
DGLY26
DTHR27
DGLY28
DGLU29
DLEU30
DTHR31
DAMZ401

AC425binding site for residue AMZ D 401
ChainResidue
BVAL17
BGLU20
BGLY21
BTHR27
BGLY28
BGLU29
BLEU30
BTHR31
BLYS112
BTYR113
BARG140
B94J401
DVAL17
DGLU20
DGLY21
DTHR27
DGLY28
DGLU29
DLEU30
DTHR31
DLYS112
DTYR113
DARG140
DHOH626
DHOH660

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
94J_5pzw_A_40133N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide) binding site
ChainResidueligand
AVAL17-MET1894J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
AGLU20-ARG2294J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
AALA2494J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
AGLY26-GLN3294J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
ALEU3494J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
ATYR11394J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
AMET17794J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
CVAL17-MET1894J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
CGLU20-ARG2294J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
CALA24-GLN3294J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
CLEU3494J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
CTYR11394J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
CMET17794J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)

AMZ_5pzw_A_40231AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE binding site
ChainResidueligand
AVAL17AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
AGLU20-GLY21AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
AALA24AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
AGLY26-THR31AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
ALEU34AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
ALYS112-TYR113AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
AARG140AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
AVAL160AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
AMET177AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
CVAL17AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
CGLU20-GLY21AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
CALA24AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
CGLY26-THR31AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
CLEU34AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
CLYS112-TYR113AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
CVAL160AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
CMET177AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE

94J_5pzw_B_40131N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide) binding site
ChainResidueligand
BVAL17-MET1894J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
BGLU20-ARG2294J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
BALA24-THR3194J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
BLEU3494J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
BTYR11394J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
BMET17794J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
DVAL17-MET1894J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
DGLU20-ARG2294J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
DALA24-THR3194J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
DLEU3494J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)
DMET17794J: N,N'-(pentane-1,5-diyldicarbamoyl)bis(3-chlorobenzene-1-sulfonamide)

AMZ_5pzw_D_40133AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE binding site
ChainResidueligand
BVAL17AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
BGLU20-GLY21AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
BALA24AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
BGLY26-THR31AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
BLEU34AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
BLYS112-TYR113AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
BARG140AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
BVAL160AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
BMET177AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
DVAL17-MET18AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
DGLU20-GLY21AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
DALA24AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
DGLY26-THR31AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
DLEU34AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
DLYS112-TYR113AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
DARG140AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
DVAL160AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
DMET177AMZ: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE

?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
?

Catalytic Information from CSA

site_idNumber of ResiduesDetails
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan