5PZV

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromopyridin-2-yl)-3-(4-chlorophenyl)sulfonylurea

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Functional Information from GO Data

ChainGOidnamespacecontents
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC116binding site for residue 94G A 401
ChainResidue
AVAL17
AGLU20
AGLY21
AARG22
AGLY26
ATHR27
AGLY28
AGLU29
ALEU30
ATHR31
AMET177
AHOH533
AHOH622
CTHR27
CGLY28
C94G401

AC214binding site for residue 94G B 401
ChainResidue
BMET18
BGLU20
BGLY21
BARG22
BGLY26
BTHR27
BGLY28
BGLU29
BLEU30
BTHR31
BHOH548
DTHR27
DGLY28
D94G401

AC314binding site for residue 94G C 401
ChainResidue
ATHR27
AGLY28
A94G401
CMET18
CGLU20
CGLY21
CARG22
CALA24
CGLY26
CTHR27
CGLY28
CGLU29
CLEU30
CTHR31

AC413binding site for residue 94G D 401
ChainResidue
BTHR27
BGLY28
B94G401
DMET18
DGLY21
DARG22
DGLY26
DGLY28
DGLU29
DLEU30
DTHR31
DMET177
DHOH521

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
94G_5pzv_A_40119N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide binding site
ChainResidueligand
AVAL17-MET1894G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
AGLU20-ARG2294G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
AALA24-THR3194G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
ATYR11394G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
AMET17794G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
CGLY26-GLY2894G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
CTHR3194G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide

94G_5pzv_C_40120N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide binding site
ChainResidueligand
AGLY26-GLY2894G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
ATHR31-GLN3294G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
CVAL17-MET1894G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
CGLU20-ARG2294G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
CALA24-THR3194G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
CTYR11394G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
CMET17794G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide

94G_5pzv_B_40120N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide binding site
ChainResidueligand
BVAL17-MET1894G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
BGLU20-ARG2294G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
BALA24-THR3194G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
BTYR11394G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
BMET17794G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
DMET1894G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
DGLY26-GLY2894G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
DTHR3194G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide

94G_5pzv_D_40118N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide binding site
ChainResidueligand
BGLY26-GLY2894G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
DVAL17-MET1894G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
DGLU20-ARG2294G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
DALA24-THR3194G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
DTYR11394G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide
DMET17794G: N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails
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