5PNT

CRYSTAL STRUCTURE OF A HUMAN LOW MOLECULAR WEIGHT PHOSPHOTYROSYL PHOSPHATASE. IMPLICATIONS FOR SUBSTRATE SPECIFICITY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003993	molecular_function	acid phosphatase activity
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0004726	molecular_function	non-membrane spanning protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006470	biological_process	protein dephosphorylation
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0016791	molecular_function	phosphatase activity
A	0042383	cellular_component	sarcolemma
A	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MES A 0

Chain	Residue
A	CYS12
A	ASP129
A	TYR131
A	HOH161
A	LEU13
A	GLY14
A	ASN15
A	ILE16
A	CYS17
A	ARG18
A	GLU50
A	ARG97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P11064

Chain	Residue	Details
A	LEU13

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P11064

Chain	Residue	Details
A	SER19

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site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P11064

Chain	Residue	Details
A	PRO130

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:1939112

Chain	Residue	Details
A	GLU2

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:9038134

Chain	Residue	Details
A	TYR132
A	GLY133

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1pnt

Chain	Residue	Details
A	CYS17
A	ARG18
A	ASP129
A	CYS12

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