5PAY

Crystal Structure of Factor VIIa in complex with 1-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylurea

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 301

Chain	Residue
A	SER163
A	ASP164
A	HOH403
C	ARG331

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site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 302

Chain	Residue
C	GLY414
C	TRP416
A	GLY196
A	LYS197
A	ILE198
A	LEU201
A	GLU202

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site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 303

Chain	Residue
A	ARG173
A	CYS174
A	SER179
A	LEU180
A	HOH402
A	HOH404
A	HOH412

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site_id	AC4
Number of Residues	6
Details	binding site for residue CA C 501

Chain	Residue
C	GLU270
C	ASP272
C	GLU275
C	GLU280
C	HOH643
C	HOH793

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site_id	AC5
Number of Residues	1
Details	binding site for residue CL C 502

Chain	Residue
C	GLU454

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site_id	AC6
Number of Residues	3
Details	binding site for residue CL C 503

Chain	Residue
C	ARG262
C	GLY458
C	VAL459

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site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 C 504

Chain	Residue
C	MET366
C	THR367
C	ARG439
C	HOH605
C	HOH727
C	HOH765

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site_id	AC8
Number of Residues	7
Details	binding site for residue GOL C 505

Chain	Residue
C	PHE255
C	ASP256
C	ILE290
C	PRO296
C	LEU460
C	HOH624
C	HOH654

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site_id	AC9
Number of Residues	17
Details	binding site for residue 7ZY C 506

Chain	Residue
C	LEU237
C	HIS253
C	CYS254
C	ASP256
C	LYS257
C	GLY297
C	SER399
C	CYS400
C	LYS401
C	SER404
C	SER423
C	TRP424
C	GLY427
C	HOH611
C	HOH612
C	HOH723
C	HOH740

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
C	VAL249-CYS254

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
C	ASP398-ALA409

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site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
A	CYS172-CYS187

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
C	HIS253
C	ASP302
C	SER404

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
C	ASP398

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725

Chain	Residue	Details
C	ASN382

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