Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | SER163 |
| A | ASP164 |
| A | HOH405 |
| C | ARG331 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| C | HIS411 |
| C | GLY414 |
| C | THR415 |
| C | TRP416 |
| A | GLY196 |
| A | LYS197 |
| A | ILE198 |
| A | LEU201 |
| A | GLU202 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | ARG173 |
| A | CYS174 |
| A | SER179 |
| A | LEU180 |
| A | HOH401 |
| A | HOH403 |
| A | HOH406 |
| A | HOH407 |
| A | HOH433 |
| A | HOH449 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 501 |
| Chain | Residue |
| C | GLU270 |
| C | ASP272 |
| C | GLU275 |
| C | GLU280 |
| C | HOH648 |
| C | HOH791 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 503 |
| Chain | Residue |
| C | ARG262 |
| C | GLY458 |
| C | VAL459 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 504 |
| Chain | Residue |
| C | ARG284 |
| C | GLN310 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 C 505 |
| Chain | Residue |
| C | MET366 |
| C | THR367 |
| C | ARG439 |
| C | HOH634 |
| C | HOH694 |
| C | HOH786 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 506 |
| Chain | Residue |
| C | PHE255 |
| C | TRP261 |
| C | ILE290 |
| C | PRO296 |
| C | HOH620 |
| C | HOH651 |
| C | HOH654 |
| C | HOH737 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 507 |
| Chain | Residue |
| A | TYR193 |
| C | ASP279 |
| C | THR315 |
| C | ASP316 |
| C | HIS317 |
| C | HOH655 |
| C | HOH751 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 508 |
| Chain | Residue |
| A | LEU180 |
| A | ALA182 |
| C | GLN236 |
| C | THR353 |
| C | LEU355 |
| C | HOH615 |
| C | HOH696 |
| C | HOH705 |
| C | HOH754 |
| site_id | AD2 |
| Number of Residues | 14 |
| Details | binding site for residue 7ZM C 509 |
| Chain | Residue |
| C | HIS253 |
| C | CYS254 |
| C | ASP398 |
| C | SER399 |
| C | CYS400 |
| C | LYS401 |
| C | SER404 |
| C | VAL422 |
| C | SER423 |
| C | TRP424 |
| C | GLY425 |
| C | GLY427 |
| C | HOH617 |
| C | HOH672 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC |
| Chain | Residue | Details |
| C | VAL249-CYS254 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA |
| Chain | Residue | Details |
| C | ASP398-ALA409 | |
| site_id | PS01186 |
| Number of Residues | 16 |
| Details | EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC |
| Chain | Residue | Details |
| A | CYS172-CYS187 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system => ECO:0000250 |
| Chain | Residue | Details |
| C | HIS253 | |
| C | ASP302 | |
| C | SER404 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| C | ASP398 | |
| Chain | Residue | Details |
| C | ASN382 | |
