5PAV

Crystal Structure of Factor VIIa in complex with N-(6-aminopyridin-3-yl)-5-hydroxy-1-phenylpyrazole-4-carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 301

Chain	Residue
A	SER163
A	ASP164
A	HOH405
C	ARG331

---

site_id	AC2
Number of Residues	9
Details	binding site for residue GOL A 302

Chain	Residue
C	HIS411
C	GLY414
C	THR415
C	TRP416
A	GLY196
A	LYS197
A	ILE198
A	LEU201
A	GLU202

---

site_id	AC3
Number of Residues	10
Details	binding site for residue GOL A 303

Chain	Residue
A	ARG173
A	CYS174
A	SER179
A	LEU180
A	HOH401
A	HOH403
A	HOH406
A	HOH407
A	HOH433
A	HOH449

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA C 501

Chain	Residue
C	GLU270
C	ASP272
C	GLU275
C	GLU280
C	HOH648
C	HOH791

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CL C 503

Chain	Residue
C	ARG262
C	GLY458
C	VAL459

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CL C 504

Chain	Residue
C	ARG284
C	GLN310

---

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 C 505

Chain	Residue
C	MET366
C	THR367
C	ARG439
C	HOH634
C	HOH694
C	HOH786

---

site_id	AC8
Number of Residues	8
Details	binding site for residue GOL C 506

Chain	Residue
C	PHE255
C	TRP261
C	ILE290
C	PRO296
C	HOH620
C	HOH651
C	HOH654
C	HOH737

---

site_id	AC9
Number of Residues	7
Details	binding site for residue GOL C 507

Chain	Residue
A	TYR193
C	ASP279
C	THR315
C	ASP316
C	HIS317
C	HOH655
C	HOH751

---

site_id	AD1
Number of Residues	9
Details	binding site for residue GOL C 508

Chain	Residue
A	LEU180
A	ALA182
C	GLN236
C	THR353
C	LEU355
C	HOH615
C	HOH696
C	HOH705
C	HOH754

---

site_id	AD2
Number of Residues	14
Details	binding site for residue 7ZM C 509

Chain	Residue
C	HIS253
C	CYS254
C	ASP398
C	SER399
C	CYS400
C	LYS401
C	SER404
C	VAL422
C	SER423
C	TRP424
C	GLY425
C	GLY427
C	HOH617
C	HOH672

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
C	VAL249-CYS254

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
C	ASP398-ALA409

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
A	CYS172-CYS187

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19167329","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3264725","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---