5OY3

The structural basis of the histone demethylase KDM6B histone 3 lysine 27 specificity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0046872	molecular_function	metal ion binding
A	0071557	biological_process	histone H3-K27 demethylation
A	0071558	molecular_function	histone H3-tri/di-methyl-lysine-27 demethylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue FE A 1701

Chain	Residue
A	HIS1390
A	GLU1392
A	HIS1470
A	AKG1703
A	HOH1956

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1702

Chain	Residue
A	CYS1575
A	CYS1578
A	CYS1602
A	CYS1605

---

site_id	AC3
Number of Residues	11
Details	binding site for residue AKG A 1703

Chain	Residue
A	LYS1381
A	THR1387
A	HIS1390
A	GLU1392
A	SER1398
A	ASN1400
A	HIS1470
A	ASN1480
A	ALA1482
A	FE1701
A	HOH1942

---

site_id	AC4
Number of Residues	7
Details	binding site for residue EDO A 1704

Chain	Residue
A	LEU1202
A	PHE1353
A	GLY1360
A	PRO1487
A	LEU1488
A	HOH1804
A	HOH1900

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 1705

Chain	Residue
A	SER1187
A	ILE1188
A	HOH1858
A	HOH1963

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 1706

Chain	Residue
A	LYS1167
A	GLU1415
A	HIS1416
A	TRP1418
A	GLU1419
A	HOH1806

---

site_id	AC7
Number of Residues	8
Details	binding site for residue EDO A 1707

Chain	Residue
A	LEU1181
A	ASN1182
A	LEU1441
A	TYR1445
A	ILE1449
A	VAL1451
A	HOH1809
A	HOH1935

---

site_id	AC8
Number of Residues	9
Details	binding site for residue EDO A 1708

Chain	Residue
A	GLN1250
A	GLN1251
A	PRO1252
A	GLY1384
A	GLN1473
A	ARG1556
A	ALA1557
A	GLY1558
A	HOH1943

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO A 1709

Chain	Residue
A	TRP1519
A	ASN1520
A	ARG1523
A	TYR1622
A	HOH1839

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO A 1710

Chain	Residue
A	GLN1284
A	ALA1285
A	PHE1288
A	TRP1477
A	HOH1959

---

site_id	AD2
Number of Residues	7
Details	binding site for residue EDO A 1711

Chain	Residue
A	THR1242
A	GLU1419
A	SER1422
A	ALA1423
A	ASP1426
A	TBU1712
A	HOH1811

---

site_id	AD3
Number of Residues	5
Details	binding site for residue TBU A 1712

Chain	Residue
A	THR1242
A	GLU1244
A	EDO1711
A	HOH2051
B	ARG26

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	163
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O14607","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"PubMed","id":"15345777","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16497732","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Citrulline","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5","evidences":[{"source":"PubMed","id":"10464286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11856369","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15684425","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Lipidation: {"description":"N6-decanoyllysine","evidences":[{"source":"PubMed","id":"35939806","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---