5OVL
crystal structure of MabA bound to NADP+ from M. smegmatis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
| A | 0030497 | biological_process | fatty acid elongation |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
| B | 0030497 | biological_process | fatty acid elongation |
| B | 0050661 | molecular_function | NADP binding |
| C | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
| C | 0030497 | biological_process | fatty acid elongation |
| C | 0050661 | molecular_function | NADP binding |
| D | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
| D | 0030497 | biological_process | fatty acid elongation |
| D | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | binding site for residue NAP A 1001 |
| Chain | Residue |
| A | GLY30 |
| A | ASN96 |
| A | ALA97 |
| A | GLY98 |
| A | ILE99 |
| A | THR119 |
| A | ILE146 |
| A | GLY147 |
| A | SER148 |
| A | TYR161 |
| A | LYS165 |
| A | ASN32 |
| A | PRO191 |
| A | GLY192 |
| A | ILE194 |
| A | THR196 |
| A | ARG205 |
| A | HOH1104 |
| A | HOH1106 |
| A | HOH1134 |
| A | HOH1154 |
| A | HOH1156 |
| A | ARG33 |
| A | HOH1158 |
| A | HOH1187 |
| A | GLY34 |
| A | ILE35 |
| A | ARG55 |
| A | CYS68 |
| A | ASP69 |
| A | VAL70 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | binding site for residue NAP B 1001 |
| Chain | Residue |
| B | GLY30 |
| B | ASN32 |
| B | ARG33 |
| B | GLY34 |
| B | ILE35 |
| B | ARG55 |
| B | CYS68 |
| B | ASP69 |
| B | VAL70 |
| B | ASN96 |
| B | ALA97 |
| B | GLY98 |
| B | ILE99 |
| B | THR119 |
| B | ILE146 |
| B | GLY147 |
| B | SER148 |
| B | TYR161 |
| B | LYS165 |
| B | PRO191 |
| B | GLY192 |
| B | ILE194 |
| B | THR196 |
| B | HOH1118 |
| B | HOH1123 |
| B | HOH1132 |
| B | HOH1154 |
| B | HOH1170 |
| site_id | AC3 |
| Number of Residues | 28 |
| Details | binding site for residue NAP C 1001 |
| Chain | Residue |
| C | GLY30 |
| C | ASN32 |
| C | ARG33 |
| C | GLY34 |
| C | ILE35 |
| C | ARG55 |
| C | CYS68 |
| C | ASP69 |
| C | VAL70 |
| C | ASN96 |
| C | ALA97 |
| C | GLY98 |
| C | ILE99 |
| C | THR119 |
| C | ILE146 |
| C | GLY147 |
| C | TYR161 |
| C | LYS165 |
| C | PRO191 |
| C | GLY192 |
| C | ILE194 |
| C | THR196 |
| C | ARG205 |
| C | HOH1105 |
| C | HOH1112 |
| C | HOH1130 |
| C | HOH1196 |
| D | ARG133 |
| site_id | AC4 |
| Number of Residues | 31 |
| Details | binding site for residue NAP D 1001 |
| Chain | Residue |
| D | ASN96 |
| D | ALA97 |
| D | GLY98 |
| D | ILE99 |
| D | THR119 |
| D | ILE146 |
| D | GLY147 |
| D | SER148 |
| D | TYR161 |
| D | LYS165 |
| D | PRO191 |
| D | GLY192 |
| D | ILE194 |
| D | THR196 |
| D | HOH1105 |
| D | HOH1108 |
| D | HOH1130 |
| D | HOH1133 |
| D | HOH1175 |
| C | ASP77 |
| C | LYS81 |
| D | GLY30 |
| D | ASN32 |
| D | ARG33 |
| D | GLY34 |
| D | ILE35 |
| D | ARG55 |
| D | CYS68 |
| D | ASP69 |
| D | VAL70 |
| D | THR71 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvsgmwgignQanYAAAKAGLiGMArSIS |
| Chain | Residue | Details |
| A | SER148-SER176 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 |
| Chain | Residue | Details |
| A | TYR161 | |
| B | TYR161 | |
| C | TYR161 | |
| D | TYR161 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29717709 |
| Chain | Residue | Details |
| A | ASN32 | |
| B | ASP69 | |
| B | TYR161 | |
| B | LYS165 | |
| B | ILE194 | |
| B | ARG205 | |
| C | ASN32 | |
| C | ARG55 | |
| C | ASP69 | |
| C | TYR161 | |
| C | LYS165 | |
| A | ARG55 | |
| C | ILE194 | |
| C | ARG205 | |
| D | ASN32 | |
| D | ARG55 | |
| D | ASP69 | |
| D | TYR161 | |
| D | LYS165 | |
| D | ILE194 | |
| D | ARG205 | |
| A | ASP69 | |
| A | TYR161 | |
| A | LYS165 | |
| A | ILE194 | |
| A | ARG205 | |
| B | ASN32 | |
| B | ARG55 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P9WGT3 |
| Chain | Residue | Details |
| A | GLY98 | |
| B | GLY98 | |
| C | GLY98 | |
| D | GLY98 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Important for activity => ECO:0000250|UniProtKB:P9WGT3 |
| Chain | Residue | Details |
| A | SER148 | |
| B | SER148 | |
| C | SER148 | |
| D | SER148 |
