5OVE

Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor compound 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0007264	biological_process	small GTPase-mediated signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue EDO A 1101

Chain	Residue
A	GLU565
A	GLU680

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 1102

Chain	Residue
A	ARG786
A	GLU864
A	PRO1042
A	HOH1338
A	HOH1358

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 1103

Chain	Residue
A	TYR1031
A	HOH1299
A	ASP775
A	CYS838

---

site_id	AC4
Number of Residues	10
Details	binding site for residue AXE A 1104

Chain	Residue
A	MET878
A	ASN879
A	TYR884
A	PHE890
A	LYS898
A	LEU901
A	GLU902
A	HIS905
A	ARG950
A	HOH1302

---

Functional Information from PROSITE/UniProt

site_id	PS00720
Number of Residues	34
Details	RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK

Chain	Residue	Details
A	VAL927-LYS960

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	Domain: {"description":"N-terminal Ras-GEF","evidences":[{"source":"PROSITE-ProRule","id":"PRU00135","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	239
Details	Domain: {"description":"Ras-GEF","evidences":[{"source":"PROSITE-ProRule","id":"PRU00168","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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