Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5OU5

Crystal structure of maize chloroplastic photosynthetic NADP(+)-dependent malic enzyme

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004470	molecular_function	malic enzyme activity
A	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
A	0006090	biological_process	pyruvate metabolic process
A	0006108	biological_process	malate metabolic process
A	0008948	molecular_function	oxaloacetate decarboxylase activity
A	0009507	cellular_component	chloroplast
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
B	0004470	molecular_function	malic enzyme activity
B	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
B	0006090	biological_process	pyruvate metabolic process
B	0006108	biological_process	malate metabolic process
B	0008948	molecular_function	oxaloacetate decarboxylase activity
B	0009507	cellular_component	chloroplast
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
C	0004470	molecular_function	malic enzyme activity
C	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
C	0006090	biological_process	pyruvate metabolic process
C	0006108	biological_process	malate metabolic process
C	0008948	molecular_function	oxaloacetate decarboxylase activity
C	0009507	cellular_component	chloroplast
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0046872	molecular_function	metal ion binding
C	0051287	molecular_function	NAD binding
D	0004470	molecular_function	malic enzyme activity
D	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
D	0006090	biological_process	pyruvate metabolic process
D	0006108	biological_process	malate metabolic process
D	0008948	molecular_function	oxaloacetate decarboxylase activity
D	0009507	cellular_component	chloroplast
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0046872	molecular_function	metal ion binding
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue NA A 701

Chain	Residue
A	PHE326
A	ALA334
A	ASN349

site_id	AC2
Number of Residues	1
Details	binding site for residue NA A 702

Chain	Residue
A	SER208

site_id	AC3
Number of Residues	3
Details	binding site for residue NA A 703

Chain	Residue
A	ARG633
A	TYR635
A	HOH981

site_id	AC4
Number of Residues	2
Details	binding site for residue K A 704

Chain	Residue
A	LEU239
A	ASN492

site_id	AC5
Number of Residues	5
Details	binding site for residue NA B 701

Chain	Residue
A	PRO202
A	GLN203
A	GLY204
B	TYR98
B	LEU125

site_id	AC6
Number of Residues	5
Details	binding site for residue NA B 702

Chain	Residue
B	MET158
B	GLN161
B	VAL253
B	ALA257
B	HOH885

site_id	AC7
Number of Residues	5
Details	binding site for residue NA B 703

Chain	Residue
B	TYR539
B	ILE540
B	GLY543
B	SER593
B	ILE596

site_id	AC8
Number of Residues	5
Details	binding site for residue NA B 704

Chain	Residue
B	GLU165
B	ARG166
B	PRO267
B	TYR628
B	HOH859

site_id	AC9
Number of Residues	5
Details	binding site for residue NA B 705

Chain	Residue
B	SER489
B	SER491
B	SER497
B	GLY517
B	SER518

site_id	AD1
Number of Residues	5
Details	binding site for residue NA C 701

Chain	Residue
C	TYR539
C	ILE540
C	PRO542
C	GLY543
C	SER593

site_id	AD2
Number of Residues	6
Details	binding site for residue NA C 702

Chain	Residue
C	SER489
C	SER491
C	SER497
C	SER516
C	GLY517
C	SER518

site_id	AD3
Number of Residues	5
Details	binding site for residue NA C 703

Chain	Residue
C	MET158
C	VAL183
C	GLY254
C	HOH804
C	HOH901

site_id	AD4
Number of Residues	5
Details	binding site for residue NA C 704

Chain	Residue
C	ASP234
C	GLU236
C	PHE329
C	ALA330
C	ASN333

site_id	AD5
Number of Residues	3
Details	binding site for residue NA C 705

Chain	Residue
C	PHE326
C	ALA334
C	ASN349

site_id	AD6
Number of Residues	5
Details	binding site for residue NA D 701

Chain	Residue
C	PRO202
C	GLN203
C	GLY204
D	TYR98
D	LEU125

site_id	AD7
Number of Residues	5
Details	binding site for residue NA D 702

Chain	Residue
D	SER489
D	SER491
D	SER497
D	GLY517
D	SER518

site_id	AD8
Number of Residues	4
Details	binding site for residue NA D 703

Chain	Residue
D	TYR195
D	PHE199
D	GLN203
D	TYR206

Functional Information from PROSITE/UniProt

site_id	PS00331
Number of Residues	17
Details	MALIC_ENZYMES Malic enzymes signature. FnDDiqGTAsVvLAGLL

Chain	Residue	Details
A	PHE348-LEU364

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	TYR184
B	TYR184
C	TYR184
D	TYR184

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	LYS255
B	LYS255
C	LYS255
D	LYS255

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ARG237
B	ASP351
B	LEU380
B	ASN492
C	ARG237
C	GLU327
C	ASP328
C	ASP351
C	LEU380
C	ASN492
D	ARG237
A	GLU327
D	GLU327
D	ASP328
D	ASP351
D	LEU380
D	ASN492
A	ASP328
A	ASP351
A	LEU380
A	ASN492
B	ARG237
B	GLU327
B	ASP328

site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Important for activity => ECO:0000250

Chain	Residue	Details
A	ASP351
B	ASP351
C	ASP351
D	ASP351

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)