Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5OSI

Structure of retromer VPS29-VPS35C subunits complexed with RidL harpin loop (163-176)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005769	cellular_component	early endosome
A	0005770	cellular_component	late endosome
A	0005829	cellular_component	cytosol
A	0006886	biological_process	intracellular protein transport
A	0010008	cellular_component	endosome membrane
A	0010506	biological_process	regulation of autophagy
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0030904	cellular_component	retromer complex
A	0030906	cellular_component	retromer, cargo-selective complex
A	0032456	biological_process	endocytic recycling
A	0032991	cellular_component	protein-containing complex
A	0042147	biological_process	retrograde transport, endosome to Golgi
A	0046872	molecular_function	metal ion binding
B	0015031	biological_process	protein transport
B	0030906	cellular_component	retromer, cargo-selective complex
B	0042147	biological_process	retrograde transport, endosome to Golgi
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005768	cellular_component	endosome
D	0005769	cellular_component	early endosome
D	0005770	cellular_component	late endosome
D	0005829	cellular_component	cytosol
D	0006886	biological_process	intracellular protein transport
D	0010008	cellular_component	endosome membrane
D	0010506	biological_process	regulation of autophagy
D	0015031	biological_process	protein transport
D	0016020	cellular_component	membrane
D	0030904	cellular_component	retromer complex
D	0030906	cellular_component	retromer, cargo-selective complex
D	0032456	biological_process	endocytic recycling
D	0032991	cellular_component	protein-containing complex
D	0042147	biological_process	retrograde transport, endosome to Golgi
D	0046872	molecular_function	metal ion binding
E	0015031	biological_process	protein transport
E	0030906	cellular_component	retromer, cargo-selective complex
E	0042147	biological_process	retrograde transport, endosome to Golgi
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005768	cellular_component	endosome
G	0005769	cellular_component	early endosome
G	0005770	cellular_component	late endosome
G	0005829	cellular_component	cytosol
G	0006886	biological_process	intracellular protein transport
G	0010008	cellular_component	endosome membrane
G	0010506	biological_process	regulation of autophagy
G	0015031	biological_process	protein transport
G	0016020	cellular_component	membrane
G	0030904	cellular_component	retromer complex
G	0030906	cellular_component	retromer, cargo-selective complex
G	0032456	biological_process	endocytic recycling
G	0032991	cellular_component	protein-containing complex
G	0042147	biological_process	retrograde transport, endosome to Golgi
G	0046872	molecular_function	metal ion binding
H	0015031	biological_process	protein transport
H	0030906	cellular_component	retromer, cargo-selective complex
H	0042147	biological_process	retrograde transport, endosome to Golgi
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005768	cellular_component	endosome
J	0005769	cellular_component	early endosome
J	0005770	cellular_component	late endosome
J	0005829	cellular_component	cytosol
J	0006886	biological_process	intracellular protein transport
J	0010008	cellular_component	endosome membrane
J	0010506	biological_process	regulation of autophagy
J	0015031	biological_process	protein transport
J	0016020	cellular_component	membrane
J	0030904	cellular_component	retromer complex
J	0030906	cellular_component	retromer, cargo-selective complex
J	0032456	biological_process	endocytic recycling
J	0032991	cellular_component	protein-containing complex
J	0042147	biological_process	retrograde transport, endosome to Golgi
J	0046872	molecular_function	metal ion binding
K	0015031	biological_process	protein transport
K	0030906	cellular_component	retromer, cargo-selective complex
K	0042147	biological_process	retrograde transport, endosome to Golgi

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO A 201

Chain	Residue
A	TYR139
A	ASN140
A	THR144
B	GLN538

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO B 801

Chain	Residue
B	THR634
A	ASP62
A	PHE63
B	ARG582
B	LEU585
B	GLN586

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO D 201

Chain	Residue
D	ARG60
D	ASP62
D	GLU71
D	HIS88
E	ARG582
E	HOH912

site_id	AC4
Number of Residues	2
Details	binding site for residue EDO D 202

Chain	Residue
D	GLU178
D	TYR179

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO G 201

Chain	Residue
G	ASP62
G	PHE63
G	TRP93
H	ARG582
H	GLN586
H	THR634

site_id	AC6
Number of Residues	1
Details	binding site for residue EDO H 801

Chain	Residue
H	GLU698

site_id	AC7
Number of Residues	1
Details	binding site for residue NA H 802

Chain	Residue
H	HIS565

site_id	AC8
Number of Residues	1
Details	binding site for residue EDO J 201

Chain	Residue
J	LEU25

site_id	AC9
Number of Residues	2
Details	binding site for residue EDO J 202

Chain	Residue
J	TYR165
J	HOH323

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO K 801

Chain	Residue
J	ASP62
J	PHE63
K	ARG582
K	LEU585
K	GLN586
K	LEU630
K	THR634

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO K 802

Chain	Residue
K	ILE572
K	ASP616
K	GLU617

site_id	AD3
Number of Residues	1
Details	binding site for residue EDO K 803

Chain	Residue
K	SER569

site_id	AD4
Number of Residues	1
Details	binding site for residue NA K 805

Chain	Residue
K	PHE527

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	386
Details	Region: {"description":"Interaction with IGF2R cytoplasmic domain","evidences":[{"source":"PubMed","id":"15078903","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)