5OOQ

Structure of the Mtr4 Nop53 Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000292	biological_process	RNA fragment catabolic process
A	0000460	biological_process	maturation of 5.8S rRNA
A	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0003729	molecular_function	mRNA binding
A	0003824	molecular_function	catalytic activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0006364	biological_process	rRNA processing
A	0006397	biological_process	mRNA processing
A	0006401	biological_process	RNA catabolic process
A	0008143	molecular_function	poly(A) binding
A	0016075	biological_process	rRNA catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0031499	cellular_component	TRAMP complex
A	0034458	molecular_function	3'-5' RNA helicase activity
A	0034475	biological_process	U4 snRNA 3'-end processing
A	0034476	biological_process	U5 snRNA 3'-end processing
A	0071028	biological_process	nuclear mRNA surveillance
A	0071031	biological_process	nuclear mRNA surveillance of mRNA 3'-end processing
A	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
A	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
A	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
A	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing
B	0000166	molecular_function	nucleotide binding
B	0000292	biological_process	RNA fragment catabolic process
B	0000460	biological_process	maturation of 5.8S rRNA
B	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0003724	molecular_function	RNA helicase activity
B	0003729	molecular_function	mRNA binding
B	0003824	molecular_function	catalytic activity
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0006364	biological_process	rRNA processing
B	0006397	biological_process	mRNA processing
B	0006401	biological_process	RNA catabolic process
B	0008143	molecular_function	poly(A) binding
B	0016075	biological_process	rRNA catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0031499	cellular_component	TRAMP complex
B	0034458	molecular_function	3'-5' RNA helicase activity
B	0034475	biological_process	U4 snRNA 3'-end processing
B	0034476	biological_process	U5 snRNA 3'-end processing
B	0071028	biological_process	nuclear mRNA surveillance
B	0071031	biological_process	nuclear mRNA surveillance of mRNA 3'-end processing
B	0071035	biological_process	nuclear polyadenylation-dependent rRNA catabolic process
B	0071038	biological_process	TRAMP-dependent tRNA surveillance pathway
B	0071042	biological_process	nuclear polyadenylation-dependent mRNA catabolic process
B	0071051	biological_process	poly(A)-dependent snoRNA 3'-end processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 1101

Chain	Residue
A	THR173
A	SER174
A	ALA175
A	GLY176
A	LYS177
A	THR178

---

site_id	AC2
Number of Residues	1
Details	binding site for residue SO4 A 1102

Chain	Residue
A	ARG887

---

site_id	AC3
Number of Residues	1
Details	binding site for residue SO4 A 1103

Chain	Residue
A	ARG887

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 B 1101

Chain	Residue
B	SER174
B	ALA175
B	GLY176
B	LYS177
B	THR178
B	THR173

---

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 B 1102

Chain	Residue
B	LYS834
B	HOH1204

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	312
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Motif: {"description":"DEVH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---