5ON9
Crystal structure of NikA in complex with reduced Fe-L1 (N-(2-hydroxybenzyl)-N'-(2-thiomethylbenzyl)-N,N'-ethylenediamine diacetic acid)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0015675 | biological_process | nickel cation transport |
| A | 0015833 | biological_process | peptide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0046914 | molecular_function | transition metal ion binding |
| A | 0050919 | biological_process | negative chemotaxis |
| A | 0051540 | molecular_function | metal cluster binding |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098716 | biological_process | nickel cation import across plasma membrane |
| A | 1904680 | molecular_function | peptide transmembrane transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0015675 | biological_process | nickel cation transport |
| B | 0015833 | biological_process | peptide transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| B | 0046914 | molecular_function | transition metal ion binding |
| B | 0050919 | biological_process | negative chemotaxis |
| B | 0051540 | molecular_function | metal cluster binding |
| B | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098716 | biological_process | nickel cation import across plasma membrane |
| B | 1904680 | molecular_function | peptide transmembrane transporter activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue FE A 601 |
| Chain | Residue |
| A | 9YH602 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue 9YH A 602 |
| Chain | Residue |
| A | TYR22 |
| A | THR23 |
| A | MET27 |
| A | TRP100 |
| A | ARG137 |
| A | TRP398 |
| A | FE601 |
| A | HOH794 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue DTT A 603 |
| Chain | Residue |
| A | TRP10 |
| A | PRO11 |
| A | GLY219 |
| A | ASN220 |
| A | LEU223 |
| A | GOL604 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | ASN220 |
| A | GLU247 |
| A | DTT603 |
| A | HOH740 |
| A | HOH752 |
| A | HOH1077 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 605 |
| Chain | Residue |
| A | GLN361 |
| A | LEU373 |
| B | HOH766 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 606 |
| Chain | Residue |
| A | PHE147 |
| A | LYS148 |
| A | ASN149 |
| A | LYS157 |
| A | HOH914 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 607 |
| Chain | Residue |
| A | ASN235 |
| A | ALA237 |
| A | PHE419 |
| A | GLN423 |
| A | HOH724 |
| A | HOH737 |
| A | HOH1104 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 608 |
| Chain | Residue |
| A | LEU167 |
| A | GLN168 |
| B | ALA208 |
| B | THR211 |
| B | ASP213 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 609 |
| Chain | Residue |
| A | HIS56 |
| A | HOH701 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 610 |
| Chain | Residue |
| A | LEU92 |
| A | ARG95 |
| A | VAL108 |
| A | ASP109 |
| A | VAL110 |
| A | ASN281 |
| A | HOH726 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 611 |
| Chain | Residue |
| A | ASN261 |
| A | GLU262 |
| A | LEU263 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 612 |
| Chain | Residue |
| A | THR23 |
| A | GLN26 |
| A | HOH720 |
| A | HOH1062 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue FE B 601 |
| Chain | Residue |
| B | 9YH602 |
| site_id | AD5 |
| Number of Residues | 12 |
| Details | binding site for residue 9YH B 602 |
| Chain | Residue |
| B | TYR22 |
| B | MET27 |
| B | ARG97 |
| B | TRP100 |
| B | ARG137 |
| B | TRP398 |
| B | HIS416 |
| B | THR490 |
| B | FE601 |
| B | HOH721 |
| B | HOH741 |
| B | HOH969 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 603 |
| Chain | Residue |
| B | ASN220 |
| B | GLU247 |
| B | ARG396 |
| B | THR490 |
| B | GOL604 |
| B | DTT605 |
| B | HOH759 |
| B | HOH826 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| B | GLN26 |
| B | MET27 |
| B | PHE28 |
| B | THR490 |
| B | GOL603 |
| B | HOH819 |
| B | HOH922 |
| site_id | AD8 |
| Number of Residues | 8 |
| Details | binding site for residue DTT B 605 |
| Chain | Residue |
| B | PRO11 |
| B | ARG205 |
| B | GLY219 |
| B | ASN220 |
| B | LEU223 |
| B | GOL603 |
| B | HOH887 |
| B | HOH997 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 606 |
| Chain | Residue |
| B | SER53 |
| B | TRP54 |
| B | HOH724 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 607 |
| Chain | Residue |
| B | ARG457 |
| A | ARG384 |
| A | ARG389 |
| B | LEU430 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 608 |
| Chain | Residue |
| A | ASP331 |
| A | ILE332 |
| A | ARG365 |
| B | LYS148 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 609 |
| Chain | Residue |
| A | ASP43 |
| A | HOH809 |
| B | GLN241 |
| B | ASN482 |
| B | ILE483 |
| B | PRO484 |
| B | TYR485 |
| B | HOH710 |
Functional Information from PROSITE/UniProt
| site_id | PS01040 |
| Number of Residues | 23 |
| Details | SBP_BACTERIAL_5 Bacterial extracellular solute-binding proteins, family 5 signature. AkswthseDgkTWtFtLRDDVKF |
| Chain | Residue | Details |
| A | ALA51-PHE73 |
