5OKT

Crystal structure of human Casein Kinase I delta in complex with IWP-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 9XK A 301

Chain	Residue
A	ILE15
C	ARG13
C	LEU25
C	GLY26
C	GLU34
A	LEU25
A	ALA36
A	GLU83
A	LEU84
A	LEU85
A	GLY86
A	LEU135
C	GLY12

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 302

Chain	Residue
A	SER267
A	ARG270
A	ARG274
A	HOH433
A	HOH471

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 303

Chain	Residue
A	ARG178
A	GLN214
A	GLY215
A	LYS224
A	HOH426
A	HOH431

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 304

Chain	Residue
A	ARG127
A	LYS154
A	THR174
A	GLU189

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 305

Chain	Residue
A	HIS278
A	TYR284
D	ARG274
D	HIS278

---

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 A 306

Chain	Residue
A	GLU238
A	LYS242
C	TYR167

---

site_id	AC7
Number of Residues	6
Details	binding site for residue ACT A 307

Chain	Residue
A	PRO236
A	ILE237
A	ASN253
A	ARG256
A	HOH401
C	ARG256

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ACT A 308

Chain	Residue
A	HIS50
A	LYS103
A	PHE282
A	SER283

---

site_id	AC9
Number of Residues	14
Details	binding site for residue 9XK B 301

Chain	Residue
B	ILE15
B	LEU25
B	GLU34
B	ALA36
B	TYR56
B	GLU83
B	LEU84
B	LEU85
B	GLY86
B	LEU135
D	GLY12
D	ARG13
D	GLY26
D	GLU34

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 B 302

Chain	Residue
B	SER267
B	ARG270
B	ARG274
B	HOH444

---

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 B 303

Chain	Residue
B	ARG178
B	GLN214
B	GLY215
B	LYS224
B	HOH445
B	HOH454

---

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 B 304

Chain	Residue
B	ARG127
B	LYS154
B	ASN170
B	GLU189

---

site_id	AD4
Number of Residues	9
Details	binding site for residue GOL B 305

Chain	Residue
B	GLY62
B	VAL63
B	GLY64
B	ILE65
B	THR67
B	GLU83
B	LYS141
B	LEU144
B	TYR146

---

site_id	AD5
Number of Residues	13
Details	binding site for residue 9XK C 301

Chain	Residue
A	ARG10
A	ARG13
A	LEU25
A	THR27
A	GLU34
C	ILE15
C	TYR56
C	MET82
C	GLU83
C	LEU84
C	LEU85
C	GLY86
C	LEU135

---

site_id	AD6
Number of Residues	5
Details	binding site for residue SO4 C 302

Chain	Residue
C	HOH431
C	ARG178
C	GLN214
C	GLY215
C	LYS224

---

site_id	AD7
Number of Residues	3
Details	binding site for residue SO4 C 303

Chain	Residue
C	ARG127
C	LYS154
C	LYS171

---

site_id	AD8
Number of Residues	2
Details	binding site for residue SO4 C 304

Chain	Residue
C	ARG13
C	LYS14

---

site_id	AD9
Number of Residues	3
Details	binding site for residue SO4 C 305

Chain	Residue
C	ARG157
C	ARG192
C	LYS263

---

site_id	AE1
Number of Residues	3
Details	binding site for residue SO4 C 306

Chain	Residue
C	SER267
C	ARG270
C	ARG274

---

site_id	AE2
Number of Residues	4
Details	binding site for residue SO4 C 307

Chain	Residue
B	HIS278
C	GLN271
C	ARG274
C	HIS278

---

site_id	AE3
Number of Residues	7
Details	binding site for residue GOL C 308

Chain	Residue
A	ARG256
A	SER257
A	LEU258
C	ILE237
C	GLU238
C	ASN253
C	HOH459

---

site_id	AE4
Number of Residues	11
Details	binding site for residue GOL C 309

Chain	Residue
C	ARG127
C	ASP128
C	VAL129
C	SER181
C	THR184
C	GLN190
C	ASP194
C	ASP195
C	SER198
C	HOH422
C	HOH432

---

site_id	AE5
Number of Residues	12
Details	binding site for residue 9XK D 301

Chain	Residue
B	LEU25
B	THR27
B	GLU34
D	LEU25
D	ALA36
D	MET82
D	GLU83
D	LEU84
D	LEU85
D	GLY86
D	LEU135
D	LEU138

---

site_id	AE6
Number of Residues	4
Details	binding site for residue SO4 D 302

Chain	Residue
D	ARG178
D	GLN214
D	GLY215
D	LYS224

---

site_id	AE7
Number of Residues	4
Details	binding site for residue SO4 D 303

Chain	Residue
D	ARG127
D	LYS154
D	LYS171
D	GLU189

---

site_id	AE8
Number of Residues	3
Details	binding site for residue SO4 D 304

Chain	Residue
D	SER267
D	ARG270
D	ARG274

---

site_id	AE9
Number of Residues	3
Details	binding site for residue SO4 D 305

Chain	Residue
B	GLU238
B	LYS242
D	TYR167

---

site_id	AF1
Number of Residues	3
Details	binding site for residue SO4 D 306

Chain	Residue
D	ARG157
D	ARG192
D	LYS263

---

site_id	AF2
Number of Residues	9
Details	binding site for residue GOL D 307

Chain	Residue
D	ARG127
D	ASP128
D	VAL129
D	SER181
D	THR184
D	GLN190
D	ASP194
D	ASP195
D	SER198

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlGtdiaagee..........VAIK

Chain	Residue	Details
C	ILE15-LYS38
A	ILE15-LYS38

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDVKpdNFLM

Chain	Residue	Details
C	PHE124-MET136
A	PHE124-MET136

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---