Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5OKD

Crystal structure of bovine Cytochrome bc1 in complex with inhibitor SCR0911.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0016020	cellular_component	membrane
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
B	0004222	molecular_function	metalloendopeptidase activity
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006508	biological_process	proteolysis
B	0016020	cellular_component	membrane
B	0045275	cellular_component	respiratory chain complex III
B	0046872	molecular_function	metal ion binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	quinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0022904	biological_process	respiratory electron transport chain
C	0031966	cellular_component	mitochondrial membrane
C	0045275	cellular_component	respiratory chain complex III
C	0046872	molecular_function	metal ion binding
C	0048039	molecular_function	ubiquinone binding
C	1902600	biological_process	proton transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0008121	molecular_function	quinol-cytochrome-c reductase activity
D	0009055	molecular_function	electron transfer activity
D	0016020	cellular_component	membrane
D	0020037	molecular_function	heme binding
D	0045275	cellular_component	respiratory chain complex III
D	0046872	molecular_function	metal ion binding
D	1902600	biological_process	proton transmembrane transport
E	0008121	molecular_function	quinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0016020	cellular_component	membrane
F	0045275	cellular_component	respiratory chain complex III
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0016020	cellular_component	membrane
G	0021539	biological_process	subthalamus development
G	0021548	biological_process	pons development
G	0021680	biological_process	cerebellar Purkinje cell layer development
G	0021766	biological_process	hippocampus development
G	0021794	biological_process	thalamus development
G	0021854	biological_process	hypothalamus development
G	0021860	biological_process	pyramidal neuron development
G	0030901	biological_process	midbrain development
G	0045275	cellular_component	respiratory chain complex III
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0016020	cellular_component	membrane
H	0045275	cellular_component	respiratory chain complex III
H	0098803	cellular_component	respiratory chain complex
I	0008121	molecular_function	quinol-cytochrome-c reductase activity
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0016020	cellular_component	membrane
J	0045275	cellular_component	respiratory chain complex III

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue PG4 A 501

Chain	Residue
A	TYR386
A	ARG388

site_id	AC2
Number of Residues	7
Details	binding site for residue 6PE A 502

Chain	Residue
A	SER439
A	PHE442
A	LEU444
C	HIS221
C	CDL401
D	LYS226
E	PX4202

site_id	AC3
Number of Residues	6
Details	binding site for residue CDL C 401

Chain	Residue
A	LEU444
A	ARG445
A	6PE502
C	ARG5
C	PHE18
C	ILE19

site_id	AC4
Number of Residues	14
Details	binding site for residue HEM C 402

Chain	Residue
C	GLN44
C	GLY48
C	LEU49
C	LEU51
C	ARG80
C	HIS83
C	PHE90
C	THR126
C	GLY130
C	LEU133
C	PRO134
C	HIS182
C	PHE183
C	PRO186

site_id	AC5
Number of Residues	19
Details	binding site for residue HEM C 403

Chain	Residue
C	TRP31
C	GLY34
C	LEU37
C	HIS97
C	VAL98
C	ARG100
C	SER106
C	PHE109
C	TRP113
C	GLY116
C	LEU120
C	HIS196
C	LEU197
C	LEU200
C	SER205
C	ASN206
C	9XE404
C	HOH501
C	HOH505

site_id	AC6
Number of Residues	10
Details	binding site for residue 9XE C 404

Chain	Residue
C	SER35
C	GLY38
C	ILE39
C	LEU197
C	HIS201
C	SER205
C	PHE220
C	ILE229
C	ALA232
C	HEM403

site_id	AC7
Number of Residues	3
Details	binding site for residue LMT C 405

Chain	Residue
C	ILE348
C	THR349
C	GLN352

site_id	AC8
Number of Residues	1
Details	binding site for residue PG4 C 406

Chain	Residue
C	ILE146

site_id	AC9
Number of Residues	3
Details	binding site for residue PG4 C 407

Chain	Residue
C	PHE128
C	LEU150
C	ILE164

site_id	AD1
Number of Residues	9
Details	binding site for residue CDL C 408

Chain	Residue
C	SER28
C	SER29
C	TRP30
C	MET96
C	PEE409
D	CDL503
F	GLN72
G	ARG40
G	THR41

site_id	AD2
Number of Residues	12
Details	binding site for residue PEE C 409

Chain	Residue
C	TRP30
C	TYR95
C	TYR103
C	TYR104
C	MET316
C	TRP326
C	VAL329
C	LEU332
C	CDL408
F	GLN72
G	CYS44
G	VAL48

site_id	AD3
Number of Residues	14
Details	binding site for residue HEC D 501

Chain	Residue
D	PRO163
D	VAL32
D	CYS37
D	CYS40
D	HIS41
D	ASN105
D	PRO111
D	ILE116
D	ARG120
D	TYR126
D	PHE153
D	ILE158
D	GLY159
D	MET160

site_id	AD4
Number of Residues	2
Details	binding site for residue PO4 D 502

Chain	Residue
D	GLU124
D	ARG191

site_id	AD5
Number of Residues	13
Details	binding site for residue CDL D 503

Chain	Residue
C	SER29
C	LYS227
C	LEU230
C	CDL408
D	TYR220
D	LYS223
D	ARG224
D	LYS231
G	TYR29
G	ILE34
G	ASN36
G	VAL37
G	ARG40

site_id	AD6
Number of Residues	7
Details	binding site for residue FES E 201

Chain	Residue
E	CYS139
E	HIS141
E	CYS158
E	CYS160
E	HIS161
E	SER163
E	HOH302

site_id	AD7
Number of Residues	12
Details	binding site for residue PX4 E 202

Chain	Residue
A	ASP417
A	PHE442
A	LEU444
A	6PE502
D	MET222
E	TYR37
E	THR40
E	THR44
J	PHE14
J	ARG15
J	THR17
J	PHE20

site_id	AD8
Number of Residues	5
Details	binding site for residue PO4 E 203

Chain	Residue
E	ARG15
E	PRO16
E	GLU17
G	ARG24
G	PO4101

site_id	AD9
Number of Residues	14
Details	binding site for residue PEE E 204

Chain	Residue
C	ILE78
C	LEU233
C	ILE236
D	HIS200
D	MET204
D	LYS207
D	MET208
D	MET212
E	TYR49
E	ALA50
E	ASN53
E	VAL54
E	GLN57
J	ASP36

site_id	AE1
Number of Residues	7
Details	binding site for residue CDL E 205

Chain	Residue
C	ASN159
C	TRP163
E	LYS52
E	SER56
E	VAL59
E	SER63
J	ARG33

site_id	AE2
Number of Residues	2
Details	binding site for residue PO4 F 501

Chain	Residue
B	ARG134
F	TYR93

site_id	AE3
Number of Residues	5
Details	binding site for residue PO4 G 101

Chain	Residue
E	PO4203
G	ARG24
G	ALA25
G	PHE26
G	HOH203

site_id	AE4
Number of Residues	4
Details	binding site for residue PO4 G 102

Chain	Residue
G	HIS28
G	TYR29
G	PHE30
G	SER31

site_id	AE5
Number of Residues	3
Details	binding site for residue PO4 G 103

Chain	Residue
G	ALA43
G	LEU46
G	ARG47

Functional Information from PROSITE/UniProt

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryensnnlGtSHLLRLAsSlTT

Chain	Residue	Details
B	GLY54-THR77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P31930","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CZ13","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CZ13","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q68FY0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DB77","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	161
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PDB","id":"1L0L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00968","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12269811","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15312779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16024040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16924113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9204897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1L0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D6U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"12269811","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15312779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16024040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16924113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9204897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BGY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D6U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"12269811","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15312779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16024040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16924113","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9204897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1L0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D6U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15312779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16024040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YBB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	122
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	101
Details	Domain: {"description":"Cytochrome c","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BGY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BGY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BE3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	24
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	133
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	85
Details	Domain: {"description":"Rieske","evidences":[{"source":"PROSITE-ProRule","id":"PRU00628","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9651245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BGY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D855","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9D855","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CQ69","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P99028","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)