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5OK9

CH1 chimera of human 14-3-3 sigma with the HSPB6 phosphopeptide in a conformation with swapped phosphopeptides

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001836biological_processrelease of cytochrome c from mitochondria
A0003334biological_processkeratinocyte development
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006469biological_processnegative regulation of protein kinase activity
A0006611biological_processprotein export from nucleus
A0007165biological_processsignal transduction
A0008426molecular_functionprotein kinase C inhibitor activity
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0010482biological_processregulation of epidermal cell division
A0010737biological_processprotein kinase A signaling
A0010839biological_processnegative regulation of keratinocyte proliferation
A0019901molecular_functionprotein kinase binding
A0030216biological_processkeratinocyte differentiation
A0030307biological_processpositive regulation of cell growth
A0031424biological_processkeratinization
A0042802molecular_functionidentical protein binding
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0043588biological_processskin development
A0043616biological_processkeratinocyte proliferation
A0045296molecular_functioncadherin binding
A0045606biological_processpositive regulation of epidermal cell differentiation
A0045824biological_processnegative regulation of innate immune response
A0046827biological_processpositive regulation of protein export from nucleus
A0050815molecular_functionphosphoserine residue binding
A0051219molecular_functionphosphoprotein binding
A0051726biological_processregulation of cell cycle
A0061436biological_processestablishment of skin barrier
A0070062cellular_componentextracellular exosome
A0072089biological_processstem cell proliferation
A0140311molecular_functionprotein sequestering activity
A2000647biological_processnegative regulation of stem cell proliferation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001836biological_processrelease of cytochrome c from mitochondria
B0003334biological_processkeratinocyte development
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006469biological_processnegative regulation of protein kinase activity
B0006611biological_processprotein export from nucleus
B0007165biological_processsignal transduction
B0008426molecular_functionprotein kinase C inhibitor activity
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0010482biological_processregulation of epidermal cell division
B0010737biological_processprotein kinase A signaling
B0010839biological_processnegative regulation of keratinocyte proliferation
B0019901molecular_functionprotein kinase binding
B0030216biological_processkeratinocyte differentiation
B0030307biological_processpositive regulation of cell growth
B0031424biological_processkeratinization
B0042802molecular_functionidentical protein binding
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0043588biological_processskin development
B0043616biological_processkeratinocyte proliferation
B0045296molecular_functioncadherin binding
B0045606biological_processpositive regulation of epidermal cell differentiation
B0045824biological_processnegative regulation of innate immune response
B0046827biological_processpositive regulation of protein export from nucleus
B0050815molecular_functionphosphoserine residue binding
B0051219molecular_functionphosphoprotein binding
B0051726biological_processregulation of cell cycle
B0061436biological_processestablishment of skin barrier
B0070062cellular_componentextracellular exosome
B0072089biological_processstem cell proliferation
B0140311molecular_functionprotein sequestering activity
B2000647biological_processnegative regulation of stem cell proliferation
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0001836biological_processrelease of cytochrome c from mitochondria
E0003334biological_processkeratinocyte development
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006469biological_processnegative regulation of protein kinase activity
E0006611biological_processprotein export from nucleus
E0007165biological_processsignal transduction
E0008426molecular_functionprotein kinase C inhibitor activity
E0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
E0010482biological_processregulation of epidermal cell division
E0010737biological_processprotein kinase A signaling
E0010839biological_processnegative regulation of keratinocyte proliferation
E0019901molecular_functionprotein kinase binding
E0030216biological_processkeratinocyte differentiation
E0030307biological_processpositive regulation of cell growth
E0031424biological_processkeratinization
E0042802molecular_functionidentical protein binding
E0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
E0043588biological_processskin development
E0043616biological_processkeratinocyte proliferation
E0045296molecular_functioncadherin binding
E0045606biological_processpositive regulation of epidermal cell differentiation
E0045824biological_processnegative regulation of innate immune response
E0046827biological_processpositive regulation of protein export from nucleus
E0050815molecular_functionphosphoserine residue binding
E0051219molecular_functionphosphoprotein binding
E0051726biological_processregulation of cell cycle
E0061436biological_processestablishment of skin barrier
E0070062cellular_componentextracellular exosome
E0072089biological_processstem cell proliferation
E0140311molecular_functionprotein sequestering activity
E2000647biological_processnegative regulation of stem cell proliferation
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0001836biological_processrelease of cytochrome c from mitochondria
F0003334biological_processkeratinocyte development
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006469biological_processnegative regulation of protein kinase activity
F0006611biological_processprotein export from nucleus
F0007165biological_processsignal transduction
F0008426molecular_functionprotein kinase C inhibitor activity
F0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
F0010482biological_processregulation of epidermal cell division
F0010737biological_processprotein kinase A signaling
F0010839biological_processnegative regulation of keratinocyte proliferation
F0019901molecular_functionprotein kinase binding
F0030216biological_processkeratinocyte differentiation
F0030307biological_processpositive regulation of cell growth
F0031424biological_processkeratinization
F0042802molecular_functionidentical protein binding
F0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
F0043588biological_processskin development
F0043616biological_processkeratinocyte proliferation
F0045296molecular_functioncadherin binding
F0045606biological_processpositive regulation of epidermal cell differentiation
F0045824biological_processnegative regulation of innate immune response
F0046827biological_processpositive regulation of protein export from nucleus
F0050815molecular_functionphosphoserine residue binding
F0051219molecular_functionphosphoprotein binding
F0051726biological_processregulation of cell cycle
F0061436biological_processestablishment of skin barrier
F0070062cellular_componentextracellular exosome
F0072089biological_processstem cell proliferation
F0140311molecular_functionprotein sequestering activity
F2000647biological_processnegative regulation of stem cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue PEG A 301
ChainResidue
AGLU17
AARG18
AGLU20
AASP21
AHOH406
AHOH463
BPEG302

site_idAC2
Number of Residues6
Detailsbinding site for residue PEG B 301
ChainResidue
BARG18
BTYR19
BGLU20
BASP21
AHOH475
BGLU17

site_idAC3
Number of Residues5
Detailsbinding site for residue PEG B 302
ChainResidue
APEG301
BGLU20
BGLN55
BGLU91
BHOH420

site_idAC4
Number of Residues6
Detailsbinding site for residue PEG F 301
ChainResidue
FGLU17
FARG18
FTYR19
FGLU20
FASP21
FHOH412

site_idAC5
Number of Residues6
Detailsbinding site for residue PEG F 302
ChainResidue
EARG18
ETYR19
FGLU20
FGLU91
FHOH439
FHOH442

Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG41-VAL51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsSITE: Interaction with phosphoserine on interacting protein
ChainResidueDetails
AARG56
AARG129
BARG56
BARG129
EARG56
EARG129
FARG56
FARG129

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER5
BSER5
ESER5
FSER5

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER74
BSER74
ESER74
FSER74

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:21334344, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASEP240
BSEP240
ESEP240
FSEP240

218500

PDB entries from 2024-04-17

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