5OHK
Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (high resolution)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 601 |
| Chain | Residue |
| A | CYS234 |
| A | CYS237 |
| A | CYS284 |
| A | CYS287 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue AYE A 602 |
| Chain | Residue |
| A | HIS452 |
| B | GLY75 |
| A | ASN72 |
| A | ASN75 |
| A | CYS77 |
| A | GLU159 |
| A | GLY451 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| B | LYS27-ASP52 |
| site_id | PS00972 |
| Number of Residues | 16 |
| Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLvnlGNtCFMNSlLQ |
| Chain | Residue | Details |
| A | GLY69-GLN84 |
| site_id | PS00973 |
| Number of Residues | 18 |
| Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. FrLmAVvvHhGdmhs..GHF |
| Chain | Residue | Details |
| A | PHE436-PHE453 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"18287522","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24896179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25621951","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"24896179","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
