5OHJ

Human phosphodiesterase 4B catalytic domain in complex with a pyrrolidinyl inhibitor.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ZN A 699

Chain	Residue
A	HIS410
A	HIS446
A	ASP447
A	ASP564
A	HOH714
A	HOH745

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 700

Chain	Residue
A	HOH747
A	HOH748
A	HOH749
A	ASP447
A	HOH745
A	HOH746

---

site_id	AC3
Number of Residues	22
Details	binding site for residue 9VE A 801

Chain	Residue
A	SER454
A	THR517
A	MET519
A	ASP564
A	LEU565
A	ASN567
A	PRO568
A	TYR575
A	TRP578
A	THR579
A	ILE582
A	PHE586
A	GLN589
A	PRO602
A	MET603
A	CYS604
A	SER614
A	GLN615
A	PHE618
A	ILE622
A	HOH751
A	HOH784

---

site_id	AC4
Number of Residues	6
Details	binding site for residue ZN B 699

Chain	Residue
B	HIS410
B	HIS446
B	ASP447
B	ASP564
B	HOH702
B	HOH752

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG B 700

Chain	Residue
B	ASP447
B	HOH741
B	HOH744
B	HOH747
B	HOH748
B	HOH752

---

site_id	AC6
Number of Residues	20
Details	binding site for residue 9VE B 801

Chain	Residue
B	SER454
B	THR517
B	MET519
B	ASP564
B	LEU565
B	ASN567
B	PRO568
B	TYR575
B	TRP578
B	THR579
B	ILE582
B	PHE586
B	GLN589
B	PRO602
B	MET603
B	SER614
B	GLN615
B	PHE618
B	ILE622
B	HOH750

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF

Chain	Residue	Details
A	HIS446-PHE457

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15685167","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17727341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18539455","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1RO6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XLX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XLZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QYL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10846163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15685167","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17727341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18539455","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F0J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RO6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XLX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XLZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QYL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10846163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15685167","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18539455","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F0J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RO6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XLX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XLZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3D3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15003452","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1ROR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---