5OHJ
Human phosphodiesterase 4B catalytic domain in complex with a pyrrolidinyl inhibitor.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 699 |
| Chain | Residue |
| A | HIS410 |
| A | HIS446 |
| A | ASP447 |
| A | ASP564 |
| A | HOH714 |
| A | HOH745 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 700 |
| Chain | Residue |
| A | HOH747 |
| A | HOH748 |
| A | HOH749 |
| A | ASP447 |
| A | HOH745 |
| A | HOH746 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | binding site for residue 9VE A 801 |
| Chain | Residue |
| A | SER454 |
| A | THR517 |
| A | MET519 |
| A | ASP564 |
| A | LEU565 |
| A | ASN567 |
| A | PRO568 |
| A | TYR575 |
| A | TRP578 |
| A | THR579 |
| A | ILE582 |
| A | PHE586 |
| A | GLN589 |
| A | PRO602 |
| A | MET603 |
| A | CYS604 |
| A | SER614 |
| A | GLN615 |
| A | PHE618 |
| A | ILE622 |
| A | HOH751 |
| A | HOH784 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 699 |
| Chain | Residue |
| B | HIS410 |
| B | HIS446 |
| B | ASP447 |
| B | ASP564 |
| B | HOH702 |
| B | HOH752 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 700 |
| Chain | Residue |
| B | ASP447 |
| B | HOH741 |
| B | HOH744 |
| B | HOH747 |
| B | HOH748 |
| B | HOH752 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | binding site for residue 9VE B 801 |
| Chain | Residue |
| B | SER454 |
| B | THR517 |
| B | MET519 |
| B | ASP564 |
| B | LEU565 |
| B | ASN567 |
| B | PRO568 |
| B | TYR575 |
| B | TRP578 |
| B | THR579 |
| B | ILE582 |
| B | PHE586 |
| B | GLN589 |
| B | PRO602 |
| B | MET603 |
| B | SER614 |
| B | GLN615 |
| B | PHE618 |
| B | ILE622 |
| B | HOH750 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS446-PHE457 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:15003452, ECO:0007744|PDB:1ROR |
| Chain | Residue | Details |
| A | ALA411 | |
| B | ALA411 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5 |
| Chain | Residue | Details |
| A | ALA411 | |
| A | ASP620 | |
| B | ALA411 | |
| B | ASP620 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P |
| Chain | Residue | Details |
| A | ALA415 | |
| B | ALA415 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P |
| Chain | Residue | Details |
| A | PRO451 | |
| B | PRO451 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15003452, ECO:0007744|PDB:1ROR |
| Chain | Residue | Details |
| A | GLY452 | |
| B | GLY452 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:3D3P |
| Chain | Residue | Details |
| A | THR569 | |
| B | THR569 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:15003452, ECO:0000305|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5 |
| Chain | Residue | Details |
| A | VAL623 | |
| B | VAL623 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P14646 |
| Chain | Residue | Details |
| A | LYS295 | |
| A | HIS664 | |
| B | LYS295 | |
| B | HIS664 |
