5OGK
Crystal structure of a nucleotide sugar transporter with bound nucleotide sugar.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0005458 | molecular_function | GDP-mannose transmembrane transporter activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1990570 | biological_process | GDP-mannose transmembrane transport |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0005458 | molecular_function | GDP-mannose transmembrane transporter activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0055085 | biological_process | transmembrane transport |
| B | 1990570 | biological_process | GDP-mannose transmembrane transport |
| C | 0000139 | cellular_component | Golgi membrane |
| C | 0005458 | molecular_function | GDP-mannose transmembrane transporter activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0015297 | molecular_function | antiporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| C | 0031410 | cellular_component | cytoplasmic vesicle |
| C | 0055085 | biological_process | transmembrane transport |
| C | 1990570 | biological_process | GDP-mannose transmembrane transport |
| D | 0000139 | cellular_component | Golgi membrane |
| D | 0005458 | molecular_function | GDP-mannose transmembrane transporter activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0005789 | cellular_component | endoplasmic reticulum membrane |
| D | 0005794 | cellular_component | Golgi apparatus |
| D | 0015297 | molecular_function | antiporter activity |
| D | 0016020 | cellular_component | membrane |
| D | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| D | 0031410 | cellular_component | cytoplasmic vesicle |
| D | 0055085 | biological_process | transmembrane transport |
| D | 1990570 | biological_process | GDP-mannose transmembrane transport |
| E | 0000139 | cellular_component | Golgi membrane |
| E | 0005458 | molecular_function | GDP-mannose transmembrane transporter activity |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005783 | cellular_component | endoplasmic reticulum |
| E | 0005789 | cellular_component | endoplasmic reticulum membrane |
| E | 0005794 | cellular_component | Golgi apparatus |
| E | 0015297 | molecular_function | antiporter activity |
| E | 0016020 | cellular_component | membrane |
| E | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| E | 0031410 | cellular_component | cytoplasmic vesicle |
| E | 0055085 | biological_process | transmembrane transport |
| E | 1990570 | biological_process | GDP-mannose transmembrane transport |
| F | 0000139 | cellular_component | Golgi membrane |
| F | 0005458 | molecular_function | GDP-mannose transmembrane transporter activity |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005783 | cellular_component | endoplasmic reticulum |
| F | 0005789 | cellular_component | endoplasmic reticulum membrane |
| F | 0005794 | cellular_component | Golgi apparatus |
| F | 0015297 | molecular_function | antiporter activity |
| F | 0016020 | cellular_component | membrane |
| F | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| F | 0031410 | cellular_component | cytoplasmic vesicle |
| F | 0055085 | biological_process | transmembrane transport |
| F | 1990570 | biological_process | GDP-mannose transmembrane transport |
| G | 0000139 | cellular_component | Golgi membrane |
| G | 0005458 | molecular_function | GDP-mannose transmembrane transporter activity |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005783 | cellular_component | endoplasmic reticulum |
| G | 0005789 | cellular_component | endoplasmic reticulum membrane |
| G | 0005794 | cellular_component | Golgi apparatus |
| G | 0015297 | molecular_function | antiporter activity |
| G | 0016020 | cellular_component | membrane |
| G | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| G | 0031410 | cellular_component | cytoplasmic vesicle |
| G | 0055085 | biological_process | transmembrane transport |
| G | 1990570 | biological_process | GDP-mannose transmembrane transport |
| H | 0000139 | cellular_component | Golgi membrane |
| H | 0005458 | molecular_function | GDP-mannose transmembrane transporter activity |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005783 | cellular_component | endoplasmic reticulum |
| H | 0005789 | cellular_component | endoplasmic reticulum membrane |
| H | 0005794 | cellular_component | Golgi apparatus |
| H | 0015297 | molecular_function | antiporter activity |
| H | 0016020 | cellular_component | membrane |
| H | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| H | 0031410 | cellular_component | cytoplasmic vesicle |
| H | 0055085 | biological_process | transmembrane transport |
| H | 1990570 | biological_process | GDP-mannose transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue GDD A 401 |
| Chain | Residue |
| A | TYR28 |
| A | TYR281 |
| A | GLY285 |
| A | ALA286 |
| A | LYS289 |
| A | SER32 |
| A | MET35 |
| A | TYR114 |
| A | ASN220 |
| A | ASN221 |
| A | ILE265 |
| A | SER266 |
| A | SER269 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 402 |
| Chain | Residue |
| A | ILE314 |
| A | VAL324 |
| A | LYS328 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue OLC A 403 |
| Chain | Residue |
| A | PHE117 |
| A | LEU120 |
| A | TYR127 |
| A | VAL137 |
| A | SER139 |
| A | LEU142 |
| B | PHE306 |
| B | LEU310 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue OLC C 401 |
| Chain | Residue |
| C | TYR127 |
| C | LEU146 |
| C | OLC402 |
| E | MET140 |
| E | ILE314 |
| E | ILE321 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue OLC C 402 |
| Chain | Residue |
| C | PHE189 |
| C | OLC401 |
| E | PHE306 |
| E | LEU310 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue GDD D 401 |
| Chain | Residue |
| D | TYR28 |
| D | MET35 |
| D | TYR114 |
| D | ASN220 |
| D | ASN221 |
| D | ILE265 |
| D | SER266 |
| D | SER269 |
| D | GLY270 |
| D | TYR281 |
| D | LYS289 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue OLC D 402 |
| Chain | Residue |
| D | VAL37 |
| D | ILE292 |
| D | SER295 |
| D | GLY296 |
| D | PHE300 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue GDD E 401 |
| Chain | Residue |
| E | TYR28 |
| E | SER32 |
| E | MET35 |
| E | TYR114 |
| E | ASN221 |
| E | SER266 |
| E | SER269 |
| E | TYR281 |
| E | LYS289 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue OLC E 402 |
| Chain | Residue |
| C | MET140 |
| C | LEU310 |
| C | ILE314 |
| E | TYR127 |
| E | SER139 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue OLC G 401 |
| Chain | Residue |
| G | ILE33 |
| G | SER295 |
| G | GLY296 |
| G | PHE300 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue OLC G 402 |
| Chain | Residue |
| G | LEU310 |
| G | ILE314 |
| H | LEU120 |
| H | TYR127 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 528 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-SER16 | |
| B | MET202-ASP215 | |
| B | ARG274-THR279 | |
| B | LYS326-LYS337 | |
| C | MET1-SER16 | |
| C | GLY73-SER92 | |
| C | GLU141-SER144 | |
| C | MET202-ASP215 | |
| C | ARG274-THR279 | |
| C | LYS326-LYS337 | |
| D | MET1-SER16 | |
| A | GLY73-SER92 | |
| D | GLY73-SER92 | |
| D | GLU141-SER144 | |
| D | MET202-ASP215 | |
| D | ARG274-THR279 | |
| D | LYS326-LYS337 | |
| E | MET1-SER16 | |
| E | GLY73-SER92 | |
| E | GLU141-SER144 | |
| E | MET202-ASP215 | |
| E | ARG274-THR279 | |
| A | GLU141-SER144 | |
| E | LYS326-LYS337 | |
| F | MET1-SER16 | |
| F | GLY73-SER92 | |
| F | GLU141-SER144 | |
| F | MET202-ASP215 | |
| F | ARG274-THR279 | |
| F | LYS326-LYS337 | |
| G | MET1-SER16 | |
| G | GLY73-SER92 | |
| G | GLU141-SER144 | |
| A | MET202-ASP215 | |
| G | MET202-ASP215 | |
| G | ARG274-THR279 | |
| G | LYS326-LYS337 | |
| H | MET1-SER16 | |
| H | GLY73-SER92 | |
| H | GLU141-SER144 | |
| H | MET202-ASP215 | |
| H | ARG274-THR279 | |
| H | LYS326-LYS337 | |
| A | ARG274-THR279 | |
| A | LYS326-LYS337 | |
| B | MET1-SER16 | |
| B | GLY73-SER92 | |
| B | GLU141-SER144 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1600 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL17-VAL37 | |
| A | ASN305-ALA325 | |
| B | VAL17-VAL37 | |
| B | PHE52-LEU72 | |
| B | PHE93-ILE113 | |
| B | LEU120-MET140 | |
| B | PHE145-ALA165 | |
| B | PHE181-ILE201 | |
| B | THR216-GLU236 | |
| B | THR253-VAL273 | |
| B | THR280-PHE300 | |
| A | PHE52-LEU72 | |
| B | ASN305-ALA325 | |
| C | VAL17-VAL37 | |
| C | PHE52-LEU72 | |
| C | PHE93-ILE113 | |
| C | LEU120-MET140 | |
| C | PHE145-ALA165 | |
| C | PHE181-ILE201 | |
| C | THR216-GLU236 | |
| C | THR253-VAL273 | |
| C | THR280-PHE300 | |
| A | PHE93-ILE113 | |
| C | ASN305-ALA325 | |
| D | VAL17-VAL37 | |
| D | PHE52-LEU72 | |
| D | PHE93-ILE113 | |
| D | LEU120-MET140 | |
| D | PHE145-ALA165 | |
| D | PHE181-ILE201 | |
| D | THR216-GLU236 | |
| D | THR253-VAL273 | |
| D | THR280-PHE300 | |
| A | LEU120-MET140 | |
| D | ASN305-ALA325 | |
| E | VAL17-VAL37 | |
| E | PHE52-LEU72 | |
| E | PHE93-ILE113 | |
| E | LEU120-MET140 | |
| E | PHE145-ALA165 | |
| E | PHE181-ILE201 | |
| E | THR216-GLU236 | |
| E | THR253-VAL273 | |
| E | THR280-PHE300 | |
| A | PHE145-ALA165 | |
| E | ASN305-ALA325 | |
| F | VAL17-VAL37 | |
| F | PHE52-LEU72 | |
| F | PHE93-ILE113 | |
| F | LEU120-MET140 | |
| F | PHE145-ALA165 | |
| F | PHE181-ILE201 | |
| F | THR216-GLU236 | |
| F | THR253-VAL273 | |
| F | THR280-PHE300 | |
| A | PHE181-ILE201 | |
| F | ASN305-ALA325 | |
| G | VAL17-VAL37 | |
| G | PHE52-LEU72 | |
| G | PHE93-ILE113 | |
| G | LEU120-MET140 | |
| G | PHE145-ALA165 | |
| G | PHE181-ILE201 | |
| G | THR216-GLU236 | |
| G | THR253-VAL273 | |
| G | THR280-PHE300 | |
| A | THR216-GLU236 | |
| G | ASN305-ALA325 | |
| H | VAL17-VAL37 | |
| H | PHE52-LEU72 | |
| H | PHE93-ILE113 | |
| H | LEU120-MET140 | |
| H | PHE145-ALA165 | |
| H | PHE181-ILE201 | |
| H | THR216-GLU236 | |
| H | THR253-VAL273 | |
| H | THR280-PHE300 | |
| A | THR253-VAL273 | |
| H | ASN305-ALA325 | |
| A | THR280-PHE300 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 400 |
| Details | TOPO_DOM: Lumenal => ECO:0000255 |
| Chain | Residue | Details |
| A | THR38-ASN51 | |
| B | ASP301-ARG304 | |
| C | THR38-ASN51 | |
| C | TYR114-ASN119 | |
| C | LYS166-SER180 | |
| C | ASP237-LEU252 | |
| C | ASP301-ARG304 | |
| D | THR38-ASN51 | |
| D | TYR114-ASN119 | |
| D | LYS166-SER180 | |
| D | ASP237-LEU252 | |
| A | TYR114-ASN119 | |
| D | ASP301-ARG304 | |
| E | THR38-ASN51 | |
| E | TYR114-ASN119 | |
| E | LYS166-SER180 | |
| E | ASP237-LEU252 | |
| E | ASP301-ARG304 | |
| F | THR38-ASN51 | |
| F | TYR114-ASN119 | |
| F | LYS166-SER180 | |
| F | ASP237-LEU252 | |
| A | LYS166-SER180 | |
| F | ASP301-ARG304 | |
| G | THR38-ASN51 | |
| G | TYR114-ASN119 | |
| G | LYS166-SER180 | |
| G | ASP237-LEU252 | |
| G | ASP301-ARG304 | |
| H | THR38-ASN51 | |
| H | TYR114-ASN119 | |
| H | LYS166-SER180 | |
| H | ASP237-LEU252 | |
| A | ASP237-LEU252 | |
| H | ASP301-ARG304 | |
| A | ASP301-ARG304 | |
| B | THR38-ASN51 | |
| B | TYR114-ASN119 | |
| B | LYS166-SER180 | |
| B | ASP237-LEU252 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | THR279 | |
| B | THR279 | |
| C | THR279 | |
| D | THR279 | |
| E | THR279 | |
| F | THR279 | |
| G | THR279 | |
| H | THR279 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN119 | |
| C | ASN242 | |
| C | ASN246 | |
| C | ASN249 | |
| D | ASN119 | |
| D | ASN242 | |
| D | ASN246 | |
| D | ASN249 | |
| E | ASN119 | |
| E | ASN242 | |
| E | ASN246 | |
| A | ASN242 | |
| E | ASN249 | |
| F | ASN119 | |
| F | ASN242 | |
| F | ASN246 | |
| F | ASN249 | |
| G | ASN119 | |
| G | ASN242 | |
| G | ASN246 | |
| G | ASN249 | |
| H | ASN119 | |
| A | ASN246 | |
| H | ASN242 | |
| H | ASN246 | |
| H | ASN249 | |
| A | ASN249 | |
| B | ASN119 | |
| B | ASN242 | |
| B | ASN246 | |
| B | ASN249 | |
| C | ASN119 |
