5OG1

Cryo EM structure of the E. coli disaggregase ClpB (BAP form, DWB mutant), in the ATPgammaS state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0009408	biological_process	response to heat
A	0016887	molecular_function	ATP hydrolysis activity
A	0042026	biological_process	protein refolding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0009408	biological_process	response to heat
B	0016887	molecular_function	ATP hydrolysis activity
B	0042026	biological_process	protein refolding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0009408	biological_process	response to heat
C	0016887	molecular_function	ATP hydrolysis activity
C	0042026	biological_process	protein refolding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0009408	biological_process	response to heat
D	0016887	molecular_function	ATP hydrolysis activity
D	0042026	biological_process	protein refolding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0009408	biological_process	response to heat
E	0016887	molecular_function	ATP hydrolysis activity
E	0042026	biological_process	protein refolding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0009408	biological_process	response to heat
F	0016887	molecular_function	ATP hydrolysis activity
F	0042026	biological_process	protein refolding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue AGS C 901

Chain	Residue
B	ARG332
C	THR315
C	ILE349
C	LEU353
C	TYR357
C	ILE391
C	ASP178
C	PRO179
C	VAL180
C	GLY209
C	GLY211
C	LYS212
C	THR213
C	ALA214

---

site_id	AC2
Number of Residues	12
Details	binding site for residue AGS C 902

Chain	Residue
B	ASP593
B	LEU691
B	ASP695
B	ASP696
B	GLU752
B	ARG756
C	GLY610
C	LYS611
C	THR612
C	GLU613
C	ARG631
C	ARG815

---

site_id	AC3
Number of Residues	12
Details	binding site for residue AGS E 901

Chain	Residue
E	ARG183
E	GLY209
E	VAL210
E	GLY211
E	LYS212
E	THR213
E	ALA214
E	ASP278
E	ALA313
E	ILE349
E	PRO387
E	ASP388

---

site_id	AC4
Number of Residues	12
Details	binding site for residue AGS E 902

Chain	Residue
D	ASP696
E	ARG569
E	GLY610
E	LYS611
E	THR612
E	GLU613
E	ARG631
E	ASP677
E	THR717
E	ASN719
E	GLN778
E	ARG815

---

site_id	AC5
Number of Residues	10
Details	binding site for residue AGS D 901

Chain	Residue
C	ALA328
D	PRO208
D	GLY209
D	VAL210
D	GLY211
D	LYS212
D	THR213
D	PRO387
D	ASP388
D	ILE391

---

site_id	AC6
Number of Residues	11
Details	binding site for residue AGS D 902

Chain	Residue
C	LEU691
C	ASP695
C	ARG750
C	GLU752
D	VAL609
D	GLY610
D	LYS611
D	THR612
D	GLU613
D	LYS616
D	ARG631

---

site_id	AC7
Number of Residues	14
Details	binding site for residue AGS B 901

Chain	Residue
A	ALA327
A	ARG331
B	PRO179
B	ARG183
B	GLU207
B	PRO208
B	VAL210
B	GLY211
B	THR213
B	ALA214
B	LEU353
B	TYR357
B	ASP388
B	ILE391

---

Functional Information from PROSITE/UniProt

site_id	PS00870
Number of Residues	13
Details	CLPAB_1 Chaperonins clpA/B signature 1. DAGNMLKPaLarG

Chain	Residue	Details
C	ASP294-GLY306

---

site_id	PS00871
Number of Residues	19
Details	CLPAB_2 Chaperonins clpA/B signature 2. RIDmSEFmEKhSvSRLvGA

Chain	Residue	Details
C	ARG631-ALA649

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1260
Details	Region: {"description":"NBD2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	546
Details	Region: {"description":"C-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	13
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	612
Details	Region: {"description":"Linker"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	402
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	65
Details	Region: {"description":"Repeat 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01251","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---