5OFB
Crystal structure of human MORC2 (residues 1-603) with spinal muscular atrophy mutation S87L
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 701 |
| Chain | Residue |
| B | CYS499 |
| B | CYS502 |
| B | CYS525 |
| B | CYS536 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | binding site for residue ATP B 702 |
| Chain | Residue |
| B | VAL81 |
| B | LYS86 |
| B | GLY98 |
| B | GLN99 |
| B | TYR100 |
| B | GLY101 |
| B | ASN102 |
| B | GLY103 |
| B | LEU104 |
| B | LYS105 |
| B | THR197 |
| B | LYS427 |
| B | MG703 |
| B | HOH842 |
| B | HOH851 |
| B | HOH861 |
| B | HOH870 |
| B | HOH904 |
| B | HOH908 |
| B | HOH920 |
| B | GLU35 |
| B | ASN39 |
| B | ALA43 |
| B | ASP68 |
| B | MET73 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 703 |
| Chain | Residue |
| B | ASN39 |
| B | ATP702 |
| B | HOH842 |
| B | HOH908 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 704 |
| Chain | Residue |
| B | ASP69 |
| B | GLY70 |
| B | SER195 |
| B | HOH877 |
| B | HOH954 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 701 |
| Chain | Residue |
| A | CYS499 |
| A | CYS502 |
| A | CYS525 |
| A | CYS536 |
| site_id | AC6 |
| Number of Residues | 24 |
| Details | binding site for residue ATP A 702 |
| Chain | Residue |
| A | GLU35 |
| A | ASN39 |
| A | ALA43 |
| A | ASP68 |
| A | MET73 |
| A | VAL81 |
| A | LYS86 |
| A | GLY98 |
| A | GLN99 |
| A | TYR100 |
| A | GLY101 |
| A | ASN102 |
| A | GLY103 |
| A | LEU104 |
| A | LYS105 |
| A | THR197 |
| A | LYS427 |
| A | MG703 |
| A | HOH815 |
| A | HOH820 |
| A | HOH835 |
| A | HOH870 |
| A | HOH885 |
| A | HOH896 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 703 |
| Chain | Residue |
| A | ASN39 |
| A | ATP702 |
| A | HOH820 |
| A | HOH870 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29440755","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00454","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
