5OCM
Imine Reductase from Streptosporangium roseum in complex with NADP+ and 2,2,2-trifluoroacetophenone hydrate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003858 | molecular_function | 3-hydroxybutyrate dehydrogenase activity |
A | 0005829 | cellular_component | cytosol |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0035064 | molecular_function | methylated histone binding |
A | 0050661 | molecular_function | NADP binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0003858 | molecular_function | 3-hydroxybutyrate dehydrogenase activity |
B | 0005829 | cellular_component | cytosol |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0035064 | molecular_function | methylated histone binding |
B | 0050661 | molecular_function | NADP binding |
C | 0000166 | molecular_function | nucleotide binding |
C | 0003858 | molecular_function | 3-hydroxybutyrate dehydrogenase activity |
C | 0005829 | cellular_component | cytosol |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0035064 | molecular_function | methylated histone binding |
C | 0050661 | molecular_function | NADP binding |
D | 0000166 | molecular_function | nucleotide binding |
D | 0003858 | molecular_function | 3-hydroxybutyrate dehydrogenase activity |
D | 0005829 | cellular_component | cytosol |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0035064 | molecular_function | methylated histone binding |
D | 0050661 | molecular_function | NADP binding |
E | 0000166 | molecular_function | nucleotide binding |
E | 0003858 | molecular_function | 3-hydroxybutyrate dehydrogenase activity |
E | 0005829 | cellular_component | cytosol |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0035064 | molecular_function | methylated histone binding |
E | 0050661 | molecular_function | NADP binding |
F | 0000166 | molecular_function | nucleotide binding |
F | 0003858 | molecular_function | 3-hydroxybutyrate dehydrogenase activity |
F | 0005829 | cellular_component | cytosol |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0035064 | molecular_function | methylated histone binding |
F | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 26 |
Details | binding site for residue NAP A 301 |
Chain | Residue |
A | LEU11 |
A | SER68 |
A | ALA72 |
A | VAL76 |
A | SER94 |
A | ILE119 |
A | ALA121 |
A | PRO123 |
A | HOH432 |
A | HOH444 |
A | HOH455 |
A | GLY12 |
A | HOH465 |
A | HOH494 |
A | HOH496 |
F | ASP232 |
F | ALA233 |
F | 9RH302 |
F | HOH483 |
A | LEU13 |
A | MET14 |
A | ASN33 |
A | ARG34 |
A | SER35 |
A | CYS66 |
A | VAL67 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue 9RH A 302 |
Chain | Residue |
A | TRP208 |
A | THR237 |
A | HIS238 |
A | THR241 |
F | SER94 |
F | ILE122 |
F | LEU174 |
F | NAP301 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue MG A 303 |
Chain | Residue |
A | HOH471 |
C | ARG2 |
C | HOH536 |
site_id | AC4 |
Number of Residues | 26 |
Details | binding site for residue NAP B 301 |
Chain | Residue |
B | LEU11 |
B | GLY12 |
B | LEU13 |
B | MET14 |
B | ASN33 |
B | ARG34 |
B | SER35 |
B | LYS38 |
B | CYS66 |
B | VAL67 |
B | SER68 |
B | ALA72 |
B | VAL76 |
B | SER94 |
B | ILE119 |
B | ALA121 |
B | PRO123 |
B | HOH456 |
B | HOH474 |
B | HOH477 |
B | HOH487 |
B | HOH488 |
B | HOH508 |
C | ASP232 |
C | ALA233 |
C | 9RH302 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue 9RH B 302 |
Chain | Residue |
B | THR237 |
B | HIS238 |
B | THR241 |
C | ILE122 |
C | LEU174 |
C | NAP301 |
site_id | AC6 |
Number of Residues | 24 |
Details | binding site for residue NAP C 301 |
Chain | Residue |
B | ASP232 |
B | ALA233 |
B | 9RH302 |
C | LEU11 |
C | GLY12 |
C | LEU13 |
C | MET14 |
C | ASN33 |
C | ARG34 |
C | SER35 |
C | CYS66 |
C | VAL67 |
C | SER68 |
C | ALA72 |
C | VAL76 |
C | SER94 |
C | ILE119 |
C | ALA121 |
C | PRO123 |
C | HOH405 |
C | HOH425 |
C | HOH469 |
C | HOH496 |
C | HOH497 |
site_id | AC7 |
Number of Residues | 8 |
Details | binding site for residue 9RH C 302 |
Chain | Residue |
C | HIS238 |
C | THR241 |
B | SER94 |
B | ILE122 |
B | LEU174 |
B | NAP301 |
C | TRP208 |
C | THR237 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue MG C 303 |
Chain | Residue |
C | HOH411 |
C | HOH426 |
C | HOH483 |
C | HOH594 |
C | HOH599 |
C | HOH601 |
site_id | AC9 |
Number of Residues | 27 |
Details | binding site for residue NAP D 301 |
Chain | Residue |
D | LEU11 |
D | GLY12 |
D | LEU13 |
D | MET14 |
D | ASN33 |
D | ARG34 |
D | SER35 |
D | CYS66 |
D | VAL67 |
D | SER68 |
D | ALA72 |
D | VAL76 |
D | SER94 |
D | ILE119 |
D | ALA121 |
D | PRO123 |
D | HOH418 |
D | HOH437 |
D | HOH439 |
D | HOH447 |
D | HOH486 |
D | HOH494 |
D | HOH499 |
D | HOH511 |
E | ASP232 |
E | ALA233 |
E | 9RH302 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue 9RH D 302 |
Chain | Residue |
D | THR237 |
D | HIS238 |
D | THR241 |
E | ILE122 |
E | LEU174 |
E | NAP301 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for residue MG D 303 |
Chain | Residue |
D | HOH420 |
D | HOH504 |
D | HOH565 |
D | HOH584 |
E | HOH430 |
E | HOH484 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue MG D 304 |
Chain | Residue |
D | HOH475 |
D | HOH483 |
D | HOH484 |
D | HOH583 |
D | HOH590 |
D | HOH592 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue MG D 305 |
Chain | Residue |
B | ASP78 |
B | HOH501 |
D | ASP3 |
D | HOH497 |
D | HOH573 |
site_id | AD5 |
Number of Residues | 27 |
Details | binding site for residue NAP E 301 |
Chain | Residue |
D | ASP232 |
D | ALA233 |
D | 9RH302 |
D | HOH465 |
E | LEU11 |
E | GLY12 |
E | LEU13 |
E | MET14 |
E | ASN33 |
E | ARG34 |
E | SER35 |
E | CYS66 |
E | VAL67 |
E | SER68 |
E | ALA72 |
E | VAL76 |
E | SER94 |
E | ILE119 |
E | ALA121 |
E | PRO123 |
E | HOH409 |
E | HOH438 |
E | HOH500 |
E | HOH510 |
E | HOH539 |
E | HOH541 |
E | HOH558 |
site_id | AD6 |
Number of Residues | 7 |
Details | binding site for residue 9RH E 302 |
Chain | Residue |
D | SER94 |
D | LEU174 |
D | NAP301 |
E | TRP208 |
E | THR237 |
E | HIS238 |
E | THR241 |
site_id | AD7 |
Number of Residues | 6 |
Details | binding site for residue MG E 303 |
Chain | Residue |
E | HOH498 |
E | HOH533 |
E | HOH536 |
E | HOH611 |
E | HOH612 |
E | HOH613 |
site_id | AD8 |
Number of Residues | 23 |
Details | binding site for residue NAP F 301 |
Chain | Residue |
A | ASP232 |
A | 9RH302 |
F | LEU11 |
F | GLY12 |
F | LEU13 |
F | MET14 |
F | ASN33 |
F | ARG34 |
F | SER35 |
F | CYS66 |
F | VAL67 |
F | SER68 |
F | ALA72 |
F | VAL76 |
F | SER94 |
F | ILE119 |
F | ALA121 |
F | PRO123 |
F | HOH408 |
F | HOH437 |
F | HOH445 |
F | HOH506 |
F | HOH507 |
site_id | AD9 |
Number of Residues | 6 |
Details | binding site for residue 9RH F 302 |
Chain | Residue |
A | SER94 |
A | LEU174 |
A | NAP301 |
F | THR237 |
F | HIS238 |
F | THR241 |
site_id | AE1 |
Number of Residues | 6 |
Details | binding site for residue MG F 303 |
Chain | Residue |
A | HOH560 |
E | HOH427 |
E | HOH531 |
E | HOH609 |
F | HOH443 |
F | HOH556 |