5OC9
Crystal Structure of human TMEM16K / Anoctamin 10
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0005229 | molecular_function | intracellularly calcium-gated chloride channel activity |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| B | 0005227 | molecular_function | calcium-activated cation channel activity |
| B | 0005229 | molecular_function | intracellularly calcium-gated chloride channel activity |
| B | 0005254 | molecular_function | chloride channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 701 |
| Chain | Residue |
| A | ASN444 |
| A | GLN445 |
| A | GLU448 |
| A | GLU500 |
| A | GLU529 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 702 |
| Chain | Residue |
| A | GLU529 |
| A | ASP533 |
| A | TYR211 |
| A | GLU448 |
| A | ASP497 |
| A | GLU500 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 703 |
| Chain | Residue |
| A | GLU259 |
| A | ALA610 |
| A | ILE613 |
| A | ASP615 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue 79M A 704 |
| Chain | Residue |
| A | VAL227 |
| A | ASP241 |
| A | LYS242 |
| A | ILE245 |
| A | 79M705 |
| B | TRP237 |
| B | LYS242 |
| B | 79M705 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue 79M A 705 |
| Chain | Residue |
| A | ILE245 |
| A | 79M704 |
| A | 79M706 |
| B | PHE235 |
| B | TRP237 |
| B | 79M705 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue 79M A 706 |
| Chain | Residue |
| A | TYR240 |
| A | 79M705 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue 79M A 707 |
| Chain | Residue |
| A | SER248 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue 79M A 708 |
| Chain | Residue |
| A | THR255 |
| A | GLU560 |
| A | SER563 |
| A | VAL564 |
| A | LEU603 |
| A | LYS606 |
| A | PHE607 |
| A | 79M709 |
| A | HOH817 |
| B | 79M709 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue 79M A 709 |
| Chain | Residue |
| A | LEU557 |
| A | GLU560 |
| A | THR561 |
| A | 79M708 |
| B | PHE607 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue 79M A 710 |
| Chain | Residue |
| A | CYS323 |
| A | TYR327 |
| A | GLU388 |
| A | HIS399 |
| A | LEU402 |
| A | LYS403 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue 79M A 711 |
| Chain | Residue |
| A | PHE502 |
| B | PHE611 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue 79M A 712 |
| Chain | Residue |
| A | PHE321 |
| A | PHE328 |
| A | TYR377 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 701 |
| Chain | Residue |
| B | ASN444 |
| B | GLN445 |
| B | GLU448 |
| B | GLU500 |
| B | GLU529 |
| B | HOH821 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 702 |
| Chain | Residue |
| B | TYR211 |
| B | GLU448 |
| B | ASP497 |
| B | GLU500 |
| B | GLU529 |
| B | ASP533 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 703 |
| Chain | Residue |
| B | GLU259 |
| B | ALA610 |
| B | ILE613 |
| B | ASP615 |
| B | HOH805 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue 79M B 705 |
| Chain | Residue |
| A | LYS242 |
| A | 79M704 |
| A | 79M705 |
| B | VAL227 |
| B | TRP237 |
| B | ASP241 |
| B | LYS242 |
| B | ILE245 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue 79M B 706 |
| Chain | Residue |
| A | PHE235 |
| B | ILE245 |
| B | 79M707 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue 79M B 707 |
| Chain | Residue |
| B | TYR240 |
| B | 79M706 |
| B | 79M708 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue 79M B 708 |
| Chain | Residue |
| B | TYR240 |
| B | SER248 |
| B | LEU251 |
| B | VAL583 |
| B | PHE584 |
| B | ILE594 |
| B | VAL595 |
| B | 79M707 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue 79M B 709 |
| Chain | Residue |
| B | GLU560 |
| B | SER563 |
| B | VAL564 |
| B | LEU603 |
| B | LYS606 |
| B | PHE607 |
| B | 79M710 |
| B | HOH809 |
| A | 79M708 |
| B | THR255 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue 79M B 710 |
| Chain | Residue |
| A | PHE607 |
| B | LEU557 |
| B | GLU560 |
| B | 79M709 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue 79M B 711 |
| Chain | Residue |
| B | GLU388 |
| B | HIS399 |
| B | LEU402 |
| B | LYS403 |
| site_id | AE5 |
| Number of Residues | 1 |
| Details | binding site for residue 79M B 712 |
| Chain | Residue |
| B | PHE502 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue 79M B 713 |
| Chain | Residue |
| B | PHE321 |
| B | PHE328 |
| B | PHE407 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 730 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-THR207 | |
| B | ALA612-THR660 | |
| A | LYS262-LEU316 | |
| A | ASN374-LEU400 | |
| A | ALA522-GLY553 | |
| A | ALA612-THR660 | |
| B | MET1-THR207 | |
| B | LYS262-LEU316 | |
| B | ASN374-LEU400 | |
| B | ALA522-GLY553 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 320 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE208-ILE228 | |
| B | ASP241-TRP261 | |
| B | VAL317-PHE337 | |
| B | GLU353-MET373 | |
| B | ILE401-PHE421 | |
| B | LEU501-PHE521 | |
| B | VAL554-ILE574 | |
| B | LEU591-PHE611 | |
| A | ASP241-TRP261 | |
| A | VAL317-PHE337 | |
| A | GLU353-MET373 | |
| A | ILE401-PHE421 | |
| A | LEU501-PHE521 | |
| A | VAL554-ILE574 | |
| A | LEU591-PHE611 | |
| B | ILE208-ILE228 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 236 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY229-TYR240 | |
| A | ASP338-SER352 | |
| A | VAL422-GLU500 | |
| A | GLY575-ASP590 | |
| B | GLY229-TYR240 | |
| B | ASP338-SER352 | |
| B | VAL422-GLU500 | |
| B | GLY575-ASP590 |
