5O9Z

Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex)

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000398	biological_process	mRNA splicing, via spliceosome
1	0001650	cellular_component	fibrillar center
1	0003676	molecular_function	nucleic acid binding
1	0003723	molecular_function	RNA binding
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005681	cellular_component	spliceosomal complex
1	0005684	cellular_component	U2-type spliceosomal complex
1	0005685	cellular_component	U1 snRNP
1	0005686	cellular_component	U2 snRNP
1	0006397	biological_process	mRNA processing
1	0008380	biological_process	RNA splicing
1	0016607	cellular_component	nuclear speck
1	0030619	molecular_function	U1 snRNA binding
1	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
1	0071005	cellular_component	U2-type precatalytic spliceosome
1	0071007	cellular_component	U2-type catalytic step 2 spliceosome
1	0071013	cellular_component	catalytic step 2 spliceosome
1	1903241	biological_process	U2-type prespliceosome assembly
a	0000245	biological_process	spliceosomal complex assembly
a	0000387	biological_process	spliceosomal snRNP assembly
a	0000398	biological_process	mRNA splicing, via spliceosome
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005681	cellular_component	spliceosomal complex
a	0005682	cellular_component	U5 snRNP
a	0005684	cellular_component	U2-type spliceosomal complex
a	0005685	cellular_component	U1 snRNP
a	0005686	cellular_component	U2 snRNP
a	0005687	cellular_component	U4 snRNP
a	0005689	cellular_component	U12-type spliceosomal complex
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0006397	biological_process	mRNA processing
a	0008380	biological_process	RNA splicing
a	0030532	cellular_component	small nuclear ribonucleoprotein complex
a	0034709	cellular_component	methylosome
a	0034715	cellular_component	pICln-Sm protein complex
a	0034719	cellular_component	SMN-Sm protein complex
a	0036261	biological_process	7-methylguanosine cap hypermethylation
a	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
a	0070062	cellular_component	extracellular exosome
a	0071005	cellular_component	U2-type precatalytic spliceosome
a	0071007	cellular_component	U2-type catalytic step 2 spliceosome
a	0071011	cellular_component	precatalytic spliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	1903241	biological_process	U2-type prespliceosome assembly
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000375	biological_process	RNA splicing, via transesterification reactions
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0016020	cellular_component	membrane
A	0016607	cellular_component	nuclear speck
A	0017070	molecular_function	U6 snRNA binding
A	0030532	cellular_component	small nuclear ribonucleoprotein complex
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071006	cellular_component	U2-type catalytic step 1 spliceosome
A	0071007	cellular_component	U2-type catalytic step 2 spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0097157	molecular_function	pre-mRNA intronic binding
A	0140492	molecular_function	metal-dependent deubiquitinase activity
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005681	cellular_component	spliceosomal complex
b	0005682	cellular_component	U5 snRNP
b	0005683	cellular_component	U7 snRNP
b	0005684	cellular_component	U2-type spliceosomal complex
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005689	cellular_component	U12-type spliceosomal complex
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0030532	cellular_component	small nuclear ribonucleoprotein complex
b	0034709	cellular_component	methylosome
b	0034715	cellular_component	pICln-Sm protein complex
b	0034719	cellular_component	SMN-Sm protein complex
b	0036261	biological_process	7-methylguanosine cap hypermethylation
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0071005	cellular_component	U2-type precatalytic spliceosome
b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	0120114	cellular_component	Sm-like protein family complex
b	1903241	biological_process	U2-type prespliceosome assembly
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003723	molecular_function	RNA binding
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005681	cellular_component	spliceosomal complex
B	0005829	cellular_component	cytosol
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0015030	cellular_component	Cajal body
B	0016020	cellular_component	membrane
B	0016607	cellular_component	nuclear speck
B	0030623	molecular_function	U5 snRNA binding
B	0042220	biological_process	response to cocaine
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071007	cellular_component	U2-type catalytic step 2 spliceosome
B	0071013	cellular_component	catalytic step 2 spliceosome
B	0071466	biological_process	cellular response to xenobiotic stimulus
c	0000245	biological_process	spliceosomal complex assembly
c	0000387	biological_process	spliceosomal snRNP assembly
c	0000398	biological_process	mRNA splicing, via spliceosome
c	0003723	molecular_function	RNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005681	cellular_component	spliceosomal complex
c	0005682	cellular_component	U5 snRNP
c	0005683	cellular_component	U7 snRNP
c	0005684	cellular_component	U2-type spliceosomal complex
c	0005685	cellular_component	U1 snRNP
c	0005686	cellular_component	U2 snRNP
c	0005687	cellular_component	U4 snRNP
c	0005689	cellular_component	U12-type spliceosomal complex
c	0005697	cellular_component	telomerase holoenzyme complex
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0006397	biological_process	mRNA processing
c	0008380	biological_process	RNA splicing
c	0030532	cellular_component	small nuclear ribonucleoprotein complex
c	0034709	cellular_component	methylosome
c	0034715	cellular_component	pICln-Sm protein complex
c	0034719	cellular_component	SMN-Sm protein complex
c	0036261	biological_process	7-methylguanosine cap hypermethylation
c	0043229	cellular_component	intracellular organelle
c	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
c	0071005	cellular_component	U2-type precatalytic spliceosome
c	0071007	cellular_component	U2-type catalytic step 2 spliceosome
c	0071011	cellular_component	precatalytic spliceosome
c	0071013	cellular_component	catalytic step 2 spliceosome
c	1903241	biological_process	U2-type prespliceosome assembly
C	0000354	biological_process	cis assembly of pre-catalytic spliceosome
C	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0001649	biological_process	osteoblast differentiation
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0003724	molecular_function	RNA helicase activity
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0005682	cellular_component	U5 snRNP
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0042802	molecular_function	identical protein binding
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0071005	cellular_component	U2-type precatalytic spliceosome
C	0071006	cellular_component	U2-type catalytic step 1 spliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
d	0000245	biological_process	spliceosomal complex assembly
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0003723	molecular_function	RNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005681	cellular_component	spliceosomal complex
d	0005682	cellular_component	U5 snRNP
d	0005683	cellular_component	U7 snRNP
d	0005684	cellular_component	U2-type spliceosomal complex
d	0005685	cellular_component	U1 snRNP
d	0005686	cellular_component	U2 snRNP
d	0005687	cellular_component	U4 snRNP
d	0005689	cellular_component	U12-type spliceosomal complex
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0006397	biological_process	mRNA processing
d	0008380	biological_process	RNA splicing
d	0030532	cellular_component	small nuclear ribonucleoprotein complex
d	0034709	cellular_component	methylosome
d	0034719	cellular_component	SMN-Sm protein complex
d	0036261	biological_process	7-methylguanosine cap hypermethylation
d	0043186	cellular_component	P granule
d	0043229	cellular_component	intracellular organelle
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0071004	cellular_component	U2-type prespliceosome
d	0071005	cellular_component	U2-type precatalytic spliceosome
d	0071007	cellular_component	U2-type catalytic step 2 spliceosome
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	0097526	cellular_component	spliceosomal tri-snRNP complex
d	1903241	biological_process	U2-type prespliceosome assembly
D	0000375	biological_process	RNA splicing, via transesterification reactions
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005681	cellular_component	spliceosomal complex
D	0005682	cellular_component	U5 snRNP
D	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
D	0005829	cellular_component	cytosol
D	0006396	biological_process	RNA processing
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0016607	cellular_component	nuclear speck
D	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
D	0071007	cellular_component	U2-type catalytic step 2 spliceosome
D	0071013	cellular_component	catalytic step 2 spliceosome
e	0000243	cellular_component	commitment complex
e	0000387	biological_process	spliceosomal snRNP assembly
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005681	cellular_component	spliceosomal complex
e	0005682	cellular_component	U5 snRNP
e	0005683	cellular_component	U7 snRNP
e	0005684	cellular_component	U2-type spliceosomal complex
e	0005685	cellular_component	U1 snRNP
e	0005686	cellular_component	U2 snRNP
e	0005687	cellular_component	U4 snRNP
e	0005689	cellular_component	U12-type spliceosomal complex
e	0005697	cellular_component	telomerase holoenzyme complex
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0006396	biological_process	RNA processing
e	0006397	biological_process	mRNA processing
e	0006479	biological_process	protein methylation
e	0008380	biological_process	RNA splicing
e	0016604	cellular_component	nuclear body
e	0019899	molecular_function	enzyme binding
e	0030532	cellular_component	small nuclear ribonucleoprotein complex
e	0034709	cellular_component	methylosome
e	0034715	cellular_component	pICln-Sm protein complex
e	0034719	cellular_component	SMN-Sm protein complex
e	0036261	biological_process	7-methylguanosine cap hypermethylation
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0070034	molecular_function	telomerase RNA binding
e	0071005	cellular_component	U2-type precatalytic spliceosome
e	0071007	cellular_component	U2-type catalytic step 2 spliceosome
e	0071011	cellular_component	precatalytic spliceosome
e	0071013	cellular_component	catalytic step 2 spliceosome
e	0071208	molecular_function	histone pre-mRNA DCP binding
e	0071209	molecular_function	U7 snRNA binding
e	0097526	cellular_component	spliceosomal tri-snRNP complex
e	1903241	biological_process	U2-type prespliceosome assembly
e	1990446	molecular_function	U1 snRNP binding
E	0000244	biological_process	spliceosomal tri-snRNP complex assembly
E	0000375	biological_process	RNA splicing, via transesterification reactions
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0005829	cellular_component	cytosol
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0015030	cellular_component	Cajal body
E	0016607	cellular_component	nuclear speck
E	0032991	cellular_component	protein-containing complex
E	0042802	molecular_function	identical protein binding
E	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
E	0071005	cellular_component	U2-type precatalytic spliceosome
f	0000387	biological_process	spliceosomal snRNP assembly
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005681	cellular_component	spliceosomal complex
f	0005682	cellular_component	U5 snRNP
f	0005683	cellular_component	U7 snRNP
f	0005684	cellular_component	U2-type spliceosomal complex
f	0005685	cellular_component	U1 snRNP
f	0005686	cellular_component	U2 snRNP
f	0005687	cellular_component	U4 snRNP
f	0005689	cellular_component	U12-type spliceosomal complex
f	0005697	cellular_component	telomerase holoenzyme complex
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0006397	biological_process	mRNA processing
f	0006479	biological_process	protein methylation
f	0008380	biological_process	RNA splicing
f	0030532	cellular_component	small nuclear ribonucleoprotein complex
f	0034709	cellular_component	methylosome
f	0034719	cellular_component	SMN-Sm protein complex
f	0036261	biological_process	7-methylguanosine cap hypermethylation
f	0043229	cellular_component	intracellular organelle
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0070034	molecular_function	telomerase RNA binding
f	0070990	molecular_function	snRNP binding
f	0071004	cellular_component	U2-type prespliceosome
f	0071005	cellular_component	U2-type precatalytic spliceosome
f	0071007	cellular_component	U2-type catalytic step 2 spliceosome
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0071204	cellular_component	histone pre-mRNA 3'end processing complex
f	0071208	molecular_function	histone pre-mRNA DCP binding
f	1903241	biological_process	U2-type prespliceosome assembly
f	1990446	molecular_function	U1 snRNP binding
f	1990447	molecular_function	U2 snRNP binding
F	0000375	biological_process	RNA splicing, via transesterification reactions
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005681	cellular_component	spliceosomal complex
F	0006396	biological_process	RNA processing
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0015030	cellular_component	Cajal body
F	0016607	cellular_component	nuclear speck
F	0017070	molecular_function	U6 snRNA binding
F	0030621	molecular_function	U4 snRNA binding
F	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
F	0071001	cellular_component	U4/U6 snRNP
F	0071005	cellular_component	U2-type precatalytic spliceosome
F	0097525	cellular_component	spliceosomal snRNP complex
g	0000243	cellular_component	commitment complex
g	0000245	biological_process	spliceosomal complex assembly
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005684	cellular_component	U2-type spliceosomal complex
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005689	cellular_component	U12-type spliceosomal complex
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0006396	biological_process	RNA processing
g	0006397	biological_process	mRNA processing
g	0008380	biological_process	RNA splicing
g	0030532	cellular_component	small nuclear ribonucleoprotein complex
g	0034709	cellular_component	methylosome
g	0034715	cellular_component	pICln-Sm protein complex
g	0034719	cellular_component	SMN-Sm protein complex
g	0036261	biological_process	7-methylguanosine cap hypermethylation
g	0043229	cellular_component	intracellular organelle
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0071005	cellular_component	U2-type precatalytic spliceosome
g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1903241	biological_process	U2-type prespliceosome assembly
G	0000244	biological_process	spliceosomal tri-snRNP complex assembly
G	0000245	biological_process	spliceosomal complex assembly
G	0000375	biological_process	RNA splicing, via transesterification reactions
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005681	cellular_component	spliceosomal complex
G	0005682	cellular_component	U5 snRNP
G	0006396	biological_process	RNA processing
G	0006397	biological_process	mRNA processing
G	0006403	biological_process	RNA localization
G	0008380	biological_process	RNA splicing
G	0016020	cellular_component	membrane
G	0016607	cellular_component	nuclear speck
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0042802	molecular_function	identical protein binding
G	0043021	molecular_function	ribonucleoprotein complex binding
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
G	0071005	cellular_component	U2-type precatalytic spliceosome
G	0071013	cellular_component	catalytic step 2 spliceosome
h	0000245	biological_process	spliceosomal complex assembly
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003723	molecular_function	RNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005681	cellular_component	spliceosomal complex
h	0005682	cellular_component	U5 snRNP
h	0005684	cellular_component	U2-type spliceosomal complex
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005689	cellular_component	U12-type spliceosomal complex
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034709	cellular_component	methylosome
h	0034715	cellular_component	pICln-Sm protein complex
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0070062	cellular_component	extracellular exosome
h	0071005	cellular_component	U2-type precatalytic spliceosome
h	0071007	cellular_component	U2-type catalytic step 2 spliceosome
h	0071011	cellular_component	precatalytic spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	1903241	biological_process	U2-type prespliceosome assembly
H	0000244	biological_process	spliceosomal tri-snRNP complex assembly
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005681	cellular_component	spliceosomal complex
H	0005684	cellular_component	U2-type spliceosomal complex
H	0005687	cellular_component	U4 snRNP
H	0005690	cellular_component	U4atac snRNP
H	0006397	biological_process	mRNA processing
H	0008380	biological_process	RNA splicing
H	0015030	cellular_component	Cajal body
H	0016607	cellular_component	nuclear speck
H	0030621	molecular_function	U4 snRNA binding
H	0030622	molecular_function	U4atac snRNA binding
H	0030674	molecular_function	protein-macromolecule adaptor activity
H	0042802	molecular_function	identical protein binding
H	0043021	molecular_function	ribonucleoprotein complex binding
H	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
H	0048254	biological_process	snoRNA localization
H	0070990	molecular_function	snRNP binding
H	0071005	cellular_component	U2-type precatalytic spliceosome
H	0071011	cellular_component	precatalytic spliceosome
H	0071166	biological_process	ribonucleoprotein complex localization
H	0071339	cellular_component	MLL1 complex
H	0097526	cellular_component	spliceosomal tri-snRNP complex
i	0000387	biological_process	spliceosomal snRNP assembly
i	0000398	biological_process	mRNA splicing, via spliceosome
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005681	cellular_component	spliceosomal complex
i	0005682	cellular_component	U5 snRNP
i	0005683	cellular_component	U7 snRNP
i	0005684	cellular_component	U2-type spliceosomal complex
i	0005685	cellular_component	U1 snRNP
i	0005686	cellular_component	U2 snRNP
i	0005687	cellular_component	U4 snRNP
i	0005689	cellular_component	U12-type spliceosomal complex
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0006397	biological_process	mRNA processing
i	0008380	biological_process	RNA splicing
i	0030532	cellular_component	small nuclear ribonucleoprotein complex
i	0034709	cellular_component	methylosome
i	0034715	cellular_component	pICln-Sm protein complex
i	0034719	cellular_component	SMN-Sm protein complex
i	0036261	biological_process	7-methylguanosine cap hypermethylation
i	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0071005	cellular_component	U2-type precatalytic spliceosome
i	0071007	cellular_component	U2-type catalytic step 2 spliceosome
i	0071013	cellular_component	catalytic step 2 spliceosome
i	0120114	cellular_component	Sm-like protein family complex
i	1903241	biological_process	U2-type prespliceosome assembly
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005681	cellular_component	spliceosomal complex
I	0006397	biological_process	mRNA processing
I	0008380	biological_process	RNA splicing
I	0071005	cellular_component	U2-type precatalytic spliceosome
I	0071011	cellular_component	precatalytic spliceosome
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005683	cellular_component	U7 snRNP
j	0005684	cellular_component	U2-type spliceosomal complex
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005689	cellular_component	U12-type spliceosomal complex
j	0005697	cellular_component	telomerase holoenzyme complex
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0006397	biological_process	mRNA processing
j	0008380	biological_process	RNA splicing
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0034709	cellular_component	methylosome
j	0034715	cellular_component	pICln-Sm protein complex
j	0034719	cellular_component	SMN-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0043229	cellular_component	intracellular organelle
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0071005	cellular_component	U2-type precatalytic spliceosome
j	0071007	cellular_component	U2-type catalytic step 2 spliceosome
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	1903241	biological_process	U2-type prespliceosome assembly
J	0000245	biological_process	spliceosomal complex assembly
J	0000375	biological_process	RNA splicing, via transesterification reactions
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005681	cellular_component	spliceosomal complex
J	0005682	cellular_component	U5 snRNP
J	0005829	cellular_component	cytosol
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
J	0051301	biological_process	cell division
J	0071005	cellular_component	U2-type precatalytic spliceosome
k	0000245	biological_process	spliceosomal complex assembly
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005681	cellular_component	spliceosomal complex
k	0005682	cellular_component	U5 snRNP
k	0005683	cellular_component	U7 snRNP
k	0005684	cellular_component	U2-type spliceosomal complex
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005687	cellular_component	U4 snRNP
k	0005689	cellular_component	U12-type spliceosomal complex
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0006397	biological_process	mRNA processing
k	0008380	biological_process	RNA splicing
k	0030532	cellular_component	small nuclear ribonucleoprotein complex
k	0034709	cellular_component	methylosome
k	0034719	cellular_component	SMN-Sm protein complex
k	0036261	biological_process	7-methylguanosine cap hypermethylation
k	0043186	cellular_component	P granule
k	0043229	cellular_component	intracellular organelle
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0071004	cellular_component	U2-type prespliceosome
k	0071005	cellular_component	U2-type precatalytic spliceosome
k	0071007	cellular_component	U2-type catalytic step 2 spliceosome
k	0071011	cellular_component	precatalytic spliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	0097526	cellular_component	spliceosomal tri-snRNP complex
k	1903241	biological_process	U2-type prespliceosome assembly
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0001527	cellular_component	microfibril
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005681	cellular_component	spliceosomal complex
K	0005684	cellular_component	U2-type spliceosomal complex
K	0005813	cellular_component	centrosome
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0071005	cellular_component	U2-type precatalytic spliceosome
l	0000243	cellular_component	commitment complex
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005681	cellular_component	spliceosomal complex
l	0005682	cellular_component	U5 snRNP
l	0005683	cellular_component	U7 snRNP
l	0005684	cellular_component	U2-type spliceosomal complex
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005687	cellular_component	U4 snRNP
l	0005689	cellular_component	U12-type spliceosomal complex
l	0005697	cellular_component	telomerase holoenzyme complex
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0006396	biological_process	RNA processing
l	0006397	biological_process	mRNA processing
l	0006479	biological_process	protein methylation
l	0008380	biological_process	RNA splicing
l	0016604	cellular_component	nuclear body
l	0019899	molecular_function	enzyme binding
l	0030532	cellular_component	small nuclear ribonucleoprotein complex
l	0034709	cellular_component	methylosome
l	0034715	cellular_component	pICln-Sm protein complex
l	0034719	cellular_component	SMN-Sm protein complex
l	0036261	biological_process	7-methylguanosine cap hypermethylation
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0070034	molecular_function	telomerase RNA binding
l	0071005	cellular_component	U2-type precatalytic spliceosome
l	0071007	cellular_component	U2-type catalytic step 2 spliceosome
l	0071011	cellular_component	precatalytic spliceosome
l	0071013	cellular_component	catalytic step 2 spliceosome
l	0071208	molecular_function	histone pre-mRNA DCP binding
l	0071209	molecular_function	U7 snRNA binding
l	0097526	cellular_component	spliceosomal tri-snRNP complex
l	1903241	biological_process	U2-type prespliceosome assembly
l	1990446	molecular_function	U1 snRNP binding
L	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
L	0016607	cellular_component	nuclear speck
L	0071005	cellular_component	U2-type precatalytic spliceosome
L	0071011	cellular_component	precatalytic spliceosome
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005681	cellular_component	spliceosomal complex
m	0005682	cellular_component	U5 snRNP
m	0005683	cellular_component	U7 snRNP
m	0005684	cellular_component	U2-type spliceosomal complex
m	0005685	cellular_component	U1 snRNP
m	0005686	cellular_component	U2 snRNP
m	0005687	cellular_component	U4 snRNP
m	0005689	cellular_component	U12-type spliceosomal complex
m	0005697	cellular_component	telomerase holoenzyme complex
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0006479	biological_process	protein methylation
m	0008380	biological_process	RNA splicing
m	0030532	cellular_component	small nuclear ribonucleoprotein complex
m	0034709	cellular_component	methylosome
m	0034719	cellular_component	SMN-Sm protein complex
m	0036261	biological_process	7-methylguanosine cap hypermethylation
m	0043229	cellular_component	intracellular organelle
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0070034	molecular_function	telomerase RNA binding
m	0070990	molecular_function	snRNP binding
m	0071004	cellular_component	U2-type prespliceosome
m	0071005	cellular_component	U2-type precatalytic spliceosome
m	0071007	cellular_component	U2-type catalytic step 2 spliceosome
m	0071013	cellular_component	catalytic step 2 spliceosome
m	0071204	cellular_component	histone pre-mRNA 3'end processing complex
m	0071208	molecular_function	histone pre-mRNA DCP binding
m	1903241	biological_process	U2-type prespliceosome assembly
m	1990446	molecular_function	U1 snRNP binding
m	1990447	molecular_function	U2 snRNP binding
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0000413	biological_process	protein peptidyl-prolyl isomerization
M	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005681	cellular_component	spliceosomal complex
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006397	biological_process	mRNA processing
M	0006457	biological_process	protein folding
M	0008380	biological_process	RNA splicing
M	0016018	molecular_function	cyclosporin A binding
M	0016607	cellular_component	nuclear speck
M	0043021	molecular_function	ribonucleoprotein complex binding
M	0043231	cellular_component	intracellular membrane-bounded organelle
M	0045070	biological_process	positive regulation of viral genome replication
M	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
M	0065003	biological_process	protein-containing complex assembly
M	0071001	cellular_component	U4/U6 snRNP
n	0000243	cellular_component	commitment complex
n	0000245	biological_process	spliceosomal complex assembly
n	0000387	biological_process	spliceosomal snRNP assembly
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005684	cellular_component	U2-type spliceosomal complex
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005689	cellular_component	U12-type spliceosomal complex
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006396	biological_process	RNA processing
n	0006397	biological_process	mRNA processing
n	0008380	biological_process	RNA splicing
n	0030532	cellular_component	small nuclear ribonucleoprotein complex
n	0034709	cellular_component	methylosome
n	0034715	cellular_component	pICln-Sm protein complex
n	0034719	cellular_component	SMN-Sm protein complex
n	0036261	biological_process	7-methylguanosine cap hypermethylation
n	0043229	cellular_component	intracellular organelle
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0071005	cellular_component	U2-type precatalytic spliceosome
n	0071007	cellular_component	U2-type catalytic step 2 spliceosome
n	0071011	cellular_component	precatalytic spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0097526	cellular_component	spliceosomal tri-snRNP complex
n	1903241	biological_process	U2-type prespliceosome assembly
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0003676	molecular_function	nucleic acid binding
N	0003677	molecular_function	DNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005681	cellular_component	spliceosomal complex
N	0006397	biological_process	mRNA processing
N	0008270	molecular_function	zinc ion binding
N	0008380	biological_process	RNA splicing
N	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
N	0046872	molecular_function	metal ion binding
N	0071005	cellular_component	U2-type precatalytic spliceosome
o	0000244	biological_process	spliceosomal tri-snRNP complex assembly
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0000932	cellular_component	P-body
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005681	cellular_component	spliceosomal complex
o	0005688	cellular_component	U6 snRNP
o	0005737	cellular_component	cytoplasm
o	0005829	cellular_component	cytosol
o	0006397	biological_process	mRNA processing
o	0006402	biological_process	mRNA catabolic process
o	0008380	biological_process	RNA splicing
o	0017070	molecular_function	U6 snRNA binding
o	0031267	molecular_function	small GTPase binding
o	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
o	0071005	cellular_component	U2-type precatalytic spliceosome
o	0071011	cellular_component	precatalytic spliceosome
o	0071013	cellular_component	catalytic step 2 spliceosome
o	0120115	cellular_component	Lsm2-8 complex
o	1990726	cellular_component	Lsm1-7-Pat1 complex
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000492	biological_process	box C/D snoRNP assembly
O	0001651	cellular_component	dense fibrillar component
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005681	cellular_component	spliceosomal complex
O	0005690	cellular_component	U4atac snRNP
O	0005730	cellular_component	nucleolus
O	0006397	biological_process	mRNA processing
O	0007338	biological_process	single fertilization
O	0008380	biological_process	RNA splicing
O	0030490	biological_process	maturation of SSU-rRNA
O	0030515	molecular_function	snoRNA binding
O	0030621	molecular_function	U4 snRNA binding
O	0030622	molecular_function	U4atac snRNA binding
O	0031428	cellular_component	box C/D methylation guide snoRNP complex
O	0032040	cellular_component	small-subunit processome
O	0032991	cellular_component	protein-containing complex
O	0034511	molecular_function	U3 snoRNA binding
O	0034512	molecular_function	box C/D sno(s)RNA binding
O	0042254	biological_process	ribosome biogenesis
O	0042274	biological_process	ribosomal small subunit biogenesis
O	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
O	0051117	molecular_function	ATPase binding
O	0071005	cellular_component	U2-type precatalytic spliceosome
O	0071011	cellular_component	precatalytic spliceosome
O	1990904	cellular_component	ribonucleoprotein complex
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0000932	cellular_component	P-body
p	0003723	molecular_function	RNA binding
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005681	cellular_component	spliceosomal complex
p	0005688	cellular_component	U6 snRNP
p	0005829	cellular_component	cytosol
p	0006397	biological_process	mRNA processing
p	0008380	biological_process	RNA splicing
p	0030629	molecular_function	U6 snRNA 3'-end binding
p	0032991	cellular_component	protein-containing complex
p	0033962	biological_process	P-body assembly
p	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
p	0071005	cellular_component	U2-type precatalytic spliceosome
p	0071011	cellular_component	precatalytic spliceosome
p	0071013	cellular_component	catalytic step 2 spliceosome
p	0120115	cellular_component	Lsm2-8 complex
p	1990726	cellular_component	Lsm1-7-Pat1 complex
P	0000387	biological_process	spliceosomal snRNP assembly
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0000481	biological_process	maturation of 5S rRNA
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005681	cellular_component	spliceosomal complex
P	0005737	cellular_component	cytoplasm
P	0005794	cellular_component	Golgi apparatus
P	0005829	cellular_component	cytosol
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0015030	cellular_component	Cajal body
P	0016607	cellular_component	nuclear speck
P	0045292	biological_process	mRNA cis splicing, via spliceosome
P	0045585	biological_process	positive regulation of cytotoxic T cell differentiation
P	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
P	0071005	cellular_component	U2-type precatalytic spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
q	0000387	biological_process	spliceosomal snRNP assembly
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0000932	cellular_component	P-body
q	0000956	biological_process	nuclear-transcribed mRNA catabolic process
q	0003723	molecular_function	RNA binding
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005681	cellular_component	spliceosomal complex
q	0005688	cellular_component	U6 snRNP
q	0005829	cellular_component	cytosol
q	0006396	biological_process	RNA processing
q	0006397	biological_process	mRNA processing
q	0008380	biological_process	RNA splicing
q	0016020	cellular_component	membrane
q	0017070	molecular_function	U6 snRNA binding
q	0032991	cellular_component	protein-containing complex
q	0033962	biological_process	P-body assembly
q	0042731	molecular_function	PH domain binding
q	0043229	cellular_component	intracellular organelle
q	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
q	0071005	cellular_component	U2-type precatalytic spliceosome
q	0097526	cellular_component	spliceosomal tri-snRNP complex
q	0120115	cellular_component	Lsm2-8 complex
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0003676	molecular_function	nucleic acid binding
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005681	cellular_component	spliceosomal complex
Q	0006397	biological_process	mRNA processing
Q	0008270	molecular_function	zinc ion binding
Q	0008380	biological_process	RNA splicing
Q	0016607	cellular_component	nuclear speck
Q	0045292	biological_process	mRNA cis splicing, via spliceosome
Q	0046872	molecular_function	metal ion binding
Q	0070064	molecular_function	proline-rich region binding
Q	0071005	cellular_component	U2-type precatalytic spliceosome
Q	0071011	cellular_component	precatalytic spliceosome
Q	1990904	cellular_component	ribonucleoprotein complex
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0003723	molecular_function	RNA binding
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005681	cellular_component	spliceosomal complex
r	0005688	cellular_component	U6 snRNP
r	0005737	cellular_component	cytoplasm
r	0005829	cellular_component	cytosol
r	0006397	biological_process	mRNA processing
r	0006402	biological_process	mRNA catabolic process
r	0008380	biological_process	RNA splicing
r	0009617	biological_process	response to bacterium
r	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
r	0046982	molecular_function	protein heterodimerization activity
r	0071005	cellular_component	U2-type precatalytic spliceosome
r	0120115	cellular_component	Lsm2-8 complex
r	1990726	cellular_component	Lsm1-7-Pat1 complex
R	0000228	cellular_component	nuclear chromosome
R	0000278	biological_process	mitotic cell cycle
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0000922	cellular_component	spindle pole
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005681	cellular_component	spliceosomal complex
R	0005694	cellular_component	chromosome
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0006397	biological_process	mRNA processing
R	0007094	biological_process	mitotic spindle assembly checkpoint signaling
R	0008380	biological_process	RNA splicing
R	0016607	cellular_component	nuclear speck
R	0034501	biological_process	protein localization to kinetochore
R	0042802	molecular_function	identical protein binding
R	0071005	cellular_component	U2-type precatalytic spliceosome
R	0097431	cellular_component	mitotic spindle pole
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0000932	cellular_component	P-body
s	0003723	molecular_function	RNA binding
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005681	cellular_component	spliceosomal complex
s	0005688	cellular_component	U6 snRNP
s	0005730	cellular_component	nucleolus
s	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
s	0005737	cellular_component	cytoplasm
s	0005829	cellular_component	cytosol
s	0006364	biological_process	rRNA processing
s	0006397	biological_process	mRNA processing
s	0006402	biological_process	mRNA catabolic process
s	0008033	biological_process	tRNA processing
s	0008380	biological_process	RNA splicing
s	0030490	biological_process	maturation of SSU-rRNA
s	0030532	cellular_component	small nuclear ribonucleoprotein complex
s	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
s	0046982	molecular_function	protein heterodimerization activity
s	0071005	cellular_component	U2-type precatalytic spliceosome
s	0120114	cellular_component	Sm-like protein family complex
s	0120115	cellular_component	Lsm2-8 complex
S	0000245	biological_process	spliceosomal complex assembly
S	0000387	biological_process	spliceosomal snRNP assembly
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005681	cellular_component	spliceosomal complex
S	0005682	cellular_component	U5 snRNP
S	0005684	cellular_component	U2-type spliceosomal complex
S	0005685	cellular_component	U1 snRNP
S	0005686	cellular_component	U2 snRNP
S	0005687	cellular_component	U4 snRNP
S	0005689	cellular_component	U12-type spliceosomal complex
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0030532	cellular_component	small nuclear ribonucleoprotein complex
S	0034709	cellular_component	methylosome
S	0034715	cellular_component	pICln-Sm protein complex
S	0034719	cellular_component	SMN-Sm protein complex
S	0036261	biological_process	7-methylguanosine cap hypermethylation
S	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
S	0070062	cellular_component	extracellular exosome
S	0071005	cellular_component	U2-type precatalytic spliceosome
S	0071007	cellular_component	U2-type catalytic step 2 spliceosome
S	0071011	cellular_component	precatalytic spliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
S	1903241	biological_process	U2-type prespliceosome assembly
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0000956	biological_process	nuclear-transcribed mRNA catabolic process
t	0003723	molecular_function	RNA binding
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005681	cellular_component	spliceosomal complex
t	0005688	cellular_component	U6 snRNP
t	0005689	cellular_component	U12-type spliceosomal complex
t	0005829	cellular_component	cytosol
t	0006397	biological_process	mRNA processing
t	0008380	biological_process	RNA splicing
t	0017070	molecular_function	U6 snRNA binding
t	0043229	cellular_component	intracellular organelle
t	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
t	0071004	cellular_component	U2-type prespliceosome
t	0071005	cellular_component	U2-type precatalytic spliceosome
t	0071013	cellular_component	catalytic step 2 spliceosome
t	0097526	cellular_component	spliceosomal tri-snRNP complex
t	0120115	cellular_component	Lsm2-8 complex
t	1990726	cellular_component	Lsm1-7-Pat1 complex
T	0000387	biological_process	spliceosomal snRNP assembly
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0003723	molecular_function	RNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005681	cellular_component	spliceosomal complex
T	0005682	cellular_component	U5 snRNP
T	0005683	cellular_component	U7 snRNP
T	0005684	cellular_component	U2-type spliceosomal complex
T	0005685	cellular_component	U1 snRNP
T	0005686	cellular_component	U2 snRNP
T	0005687	cellular_component	U4 snRNP
T	0005689	cellular_component	U12-type spliceosomal complex
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0006397	biological_process	mRNA processing
T	0008380	biological_process	RNA splicing
T	0030532	cellular_component	small nuclear ribonucleoprotein complex
T	0034709	cellular_component	methylosome
T	0034715	cellular_component	pICln-Sm protein complex
T	0034719	cellular_component	SMN-Sm protein complex
T	0036261	biological_process	7-methylguanosine cap hypermethylation
T	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
T	0071005	cellular_component	U2-type precatalytic spliceosome
T	0071007	cellular_component	U2-type catalytic step 2 spliceosome
T	0071013	cellular_component	catalytic step 2 spliceosome
T	0120114	cellular_component	Sm-like protein family complex
T	1903241	biological_process	U2-type prespliceosome assembly
u	0000398	biological_process	mRNA splicing, via spliceosome
u	0003723	molecular_function	RNA binding
u	0003729	molecular_function	mRNA binding
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005681	cellular_component	spliceosomal complex
u	0005688	cellular_component	U6 snRNP
u	0006397	biological_process	mRNA processing
u	0008380	biological_process	RNA splicing
u	0017070	molecular_function	U6 snRNA binding
u	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
u	0071005	cellular_component	U2-type precatalytic spliceosome
u	0071011	cellular_component	precatalytic spliceosome
u	0120115	cellular_component	Lsm2-8 complex
U	0000245	biological_process	spliceosomal complex assembly
U	0000387	biological_process	spliceosomal snRNP assembly
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0003723	molecular_function	RNA binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005681	cellular_component	spliceosomal complex
U	0005682	cellular_component	U5 snRNP
U	0005683	cellular_component	U7 snRNP
U	0005684	cellular_component	U2-type spliceosomal complex
U	0005685	cellular_component	U1 snRNP
U	0005686	cellular_component	U2 snRNP
U	0005687	cellular_component	U4 snRNP
U	0005689	cellular_component	U12-type spliceosomal complex
U	0005697	cellular_component	telomerase holoenzyme complex
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006397	biological_process	mRNA processing
U	0008380	biological_process	RNA splicing
U	0030532	cellular_component	small nuclear ribonucleoprotein complex
U	0034709	cellular_component	methylosome
U	0034715	cellular_component	pICln-Sm protein complex
U	0034719	cellular_component	SMN-Sm protein complex
U	0036261	biological_process	7-methylguanosine cap hypermethylation
U	0043229	cellular_component	intracellular organelle
U	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
U	0071005	cellular_component	U2-type precatalytic spliceosome
U	0071007	cellular_component	U2-type catalytic step 2 spliceosome
U	0071011	cellular_component	precatalytic spliceosome
U	0071013	cellular_component	catalytic step 2 spliceosome
U	1903241	biological_process	U2-type prespliceosome assembly
v	0000245	biological_process	spliceosomal complex assembly
v	0000375	biological_process	RNA splicing, via transesterification reactions
v	0000398	biological_process	mRNA splicing, via spliceosome
v	0003723	molecular_function	RNA binding
v	0003729	molecular_function	mRNA binding
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0005681	cellular_component	spliceosomal complex
v	0005684	cellular_component	U2-type spliceosomal complex
v	0005686	cellular_component	U2 snRNP
v	0005689	cellular_component	U12-type spliceosomal complex
v	0005730	cellular_component	nucleolus
v	0006338	biological_process	chromatin remodeling
v	0006397	biological_process	mRNA processing
v	0008380	biological_process	RNA splicing
v	0016607	cellular_component	nuclear speck
v	0034693	cellular_component	U11/U12 snRNP
v	0045943	biological_process	positive regulation of transcription by RNA polymerase I
v	0045944	biological_process	positive regulation of transcription by RNA polymerase II
v	0045945	biological_process	positive regulation of transcription by RNA polymerase III
v	0071004	cellular_component	U2-type prespliceosome
v	0071005	cellular_component	U2-type precatalytic spliceosome
v	0071013	cellular_component	catalytic step 2 spliceosome
v	0110016	cellular_component	B-WICH complex
v	1903241	biological_process	U2-type prespliceosome assembly
v	1990935	molecular_function	splicing factor binding
V	0000245	biological_process	spliceosomal complex assembly
V	0000387	biological_process	spliceosomal snRNP assembly
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0003723	molecular_function	RNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005681	cellular_component	spliceosomal complex
V	0005682	cellular_component	U5 snRNP
V	0005683	cellular_component	U7 snRNP
V	0005684	cellular_component	U2-type spliceosomal complex
V	0005685	cellular_component	U1 snRNP
V	0005686	cellular_component	U2 snRNP
V	0005687	cellular_component	U4 snRNP
V	0005689	cellular_component	U12-type spliceosomal complex
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0006397	biological_process	mRNA processing
V	0008380	biological_process	RNA splicing
V	0030532	cellular_component	small nuclear ribonucleoprotein complex
V	0034709	cellular_component	methylosome
V	0034719	cellular_component	SMN-Sm protein complex
V	0036261	biological_process	7-methylguanosine cap hypermethylation
V	0043186	cellular_component	P granule
V	0043229	cellular_component	intracellular organelle
V	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
V	0071004	cellular_component	U2-type prespliceosome
V	0071005	cellular_component	U2-type precatalytic spliceosome
V	0071007	cellular_component	U2-type catalytic step 2 spliceosome
V	0071011	cellular_component	precatalytic spliceosome
V	0071013	cellular_component	catalytic step 2 spliceosome
V	0097526	cellular_component	spliceosomal tri-snRNP complex
V	1903241	biological_process	U2-type prespliceosome assembly
w	0000124	cellular_component	SAGA complex
w	0000375	biological_process	RNA splicing, via transesterification reactions
w	0000398	biological_process	mRNA splicing, via spliceosome
w	0003676	molecular_function	nucleic acid binding
w	0005515	molecular_function	protein binding
w	0005634	cellular_component	nucleus
w	0005654	cellular_component	nucleoplasm
w	0005681	cellular_component	spliceosomal complex
w	0005684	cellular_component	U2-type spliceosomal complex
w	0005686	cellular_component	U2 snRNP
w	0005689	cellular_component	U12-type spliceosomal complex
w	0005730	cellular_component	nucleolus
w	0006282	biological_process	regulation of DNA repair
w	0006397	biological_process	mRNA processing
w	0008380	biological_process	RNA splicing
w	0030620	molecular_function	U2 snRNA binding
w	0042177	biological_process	negative regulation of protein catabolic process
w	0043484	biological_process	regulation of RNA splicing
w	0044877	molecular_function	protein-containing complex binding
w	0045893	biological_process	positive regulation of DNA-templated transcription
w	0071005	cellular_component	U2-type precatalytic spliceosome
w	0071013	cellular_component	catalytic step 2 spliceosome
w	1903241	biological_process	U2-type prespliceosome assembly
W	0000243	cellular_component	commitment complex
W	0000387	biological_process	spliceosomal snRNP assembly
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005681	cellular_component	spliceosomal complex
W	0005682	cellular_component	U5 snRNP
W	0005683	cellular_component	U7 snRNP
W	0005684	cellular_component	U2-type spliceosomal complex
W	0005685	cellular_component	U1 snRNP
W	0005686	cellular_component	U2 snRNP
W	0005687	cellular_component	U4 snRNP
W	0005689	cellular_component	U12-type spliceosomal complex
W	0005697	cellular_component	telomerase holoenzyme complex
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0006396	biological_process	RNA processing
W	0006397	biological_process	mRNA processing
W	0006479	biological_process	protein methylation
W	0008380	biological_process	RNA splicing
W	0016604	cellular_component	nuclear body
W	0019899	molecular_function	enzyme binding
W	0030532	cellular_component	small nuclear ribonucleoprotein complex
W	0034709	cellular_component	methylosome
W	0034715	cellular_component	pICln-Sm protein complex
W	0034719	cellular_component	SMN-Sm protein complex
W	0036261	biological_process	7-methylguanosine cap hypermethylation
W	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
W	0070034	molecular_function	telomerase RNA binding
W	0071005	cellular_component	U2-type precatalytic spliceosome
W	0071007	cellular_component	U2-type catalytic step 2 spliceosome
W	0071011	cellular_component	precatalytic spliceosome
W	0071013	cellular_component	catalytic step 2 spliceosome
W	0071208	molecular_function	histone pre-mRNA DCP binding
W	0071209	molecular_function	U7 snRNA binding
W	0097526	cellular_component	spliceosomal tri-snRNP complex
W	1903241	biological_process	U2-type prespliceosome assembly
W	1990446	molecular_function	U1 snRNP binding
x	0000124	cellular_component	SAGA complex
x	0000398	biological_process	mRNA splicing, via spliceosome
x	0003723	molecular_function	RNA binding
x	0005515	molecular_function	protein binding
x	0005634	cellular_component	nucleus
x	0005654	cellular_component	nucleoplasm
x	0005681	cellular_component	spliceosomal complex
x	0005684	cellular_component	U2-type spliceosomal complex
x	0005686	cellular_component	U2 snRNP
x	0005689	cellular_component	U12-type spliceosomal complex
x	0006282	biological_process	regulation of DNA repair
x	0006397	biological_process	mRNA processing
x	0008380	biological_process	RNA splicing
x	0043484	biological_process	regulation of RNA splicing
x	0045893	biological_process	positive regulation of DNA-templated transcription
x	0071005	cellular_component	U2-type precatalytic spliceosome
x	0071011	cellular_component	precatalytic spliceosome
x	1903241	biological_process	U2-type prespliceosome assembly
x	1990935	molecular_function	splicing factor binding
X	0000387	biological_process	spliceosomal snRNP assembly
X	0000398	biological_process	mRNA splicing, via spliceosome
X	0003723	molecular_function	RNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005681	cellular_component	spliceosomal complex
X	0005682	cellular_component	U5 snRNP
X	0005683	cellular_component	U7 snRNP
X	0005684	cellular_component	U2-type spliceosomal complex
X	0005685	cellular_component	U1 snRNP
X	0005686	cellular_component	U2 snRNP
X	0005687	cellular_component	U4 snRNP
X	0005689	cellular_component	U12-type spliceosomal complex
X	0005697	cellular_component	telomerase holoenzyme complex
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0006397	biological_process	mRNA processing
X	0006479	biological_process	protein methylation
X	0008380	biological_process	RNA splicing
X	0030532	cellular_component	small nuclear ribonucleoprotein complex
X	0034709	cellular_component	methylosome
X	0034719	cellular_component	SMN-Sm protein complex
X	0036261	biological_process	7-methylguanosine cap hypermethylation
X	0043229	cellular_component	intracellular organelle
X	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
X	0070034	molecular_function	telomerase RNA binding
X	0070990	molecular_function	snRNP binding
X	0071004	cellular_component	U2-type prespliceosome
X	0071005	cellular_component	U2-type precatalytic spliceosome
X	0071007	cellular_component	U2-type catalytic step 2 spliceosome
X	0071013	cellular_component	catalytic step 2 spliceosome
X	0071204	cellular_component	histone pre-mRNA 3'end processing complex
X	0071208	molecular_function	histone pre-mRNA DCP binding
X	1903241	biological_process	U2-type prespliceosome assembly
X	1990446	molecular_function	U1 snRNP binding
X	1990447	molecular_function	U2 snRNP binding
y	0000398	biological_process	mRNA splicing, via spliceosome
y	0003677	molecular_function	DNA binding
y	0003723	molecular_function	RNA binding
y	0005515	molecular_function	protein binding
y	0005634	cellular_component	nucleus
y	0005654	cellular_component	nucleoplasm
y	0005681	cellular_component	spliceosomal complex
y	0005684	cellular_component	U2-type spliceosomal complex
y	0005686	cellular_component	U2 snRNP
y	0005689	cellular_component	U12-type spliceosomal complex
y	0006397	biological_process	mRNA processing
y	0008270	molecular_function	zinc ion binding
y	0008380	biological_process	RNA splicing
y	0016363	cellular_component	nuclear matrix
y	0016607	cellular_component	nuclear speck
y	0045893	biological_process	positive regulation of DNA-templated transcription
y	0046872	molecular_function	metal ion binding
y	0048863	biological_process	stem cell differentiation
y	0071005	cellular_component	U2-type precatalytic spliceosome
y	0071011	cellular_component	precatalytic spliceosome
y	1903241	biological_process	U2-type prespliceosome assembly
Z	0000243	cellular_component	commitment complex
Z	0000245	biological_process	spliceosomal complex assembly
Z	0000387	biological_process	spliceosomal snRNP assembly
Z	0000398	biological_process	mRNA splicing, via spliceosome
Z	0003723	molecular_function	RNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005681	cellular_component	spliceosomal complex
Z	0005682	cellular_component	U5 snRNP
Z	0005684	cellular_component	U2-type spliceosomal complex
Z	0005685	cellular_component	U1 snRNP
Z	0005686	cellular_component	U2 snRNP
Z	0005687	cellular_component	U4 snRNP
Z	0005689	cellular_component	U12-type spliceosomal complex
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0006396	biological_process	RNA processing
Z	0006397	biological_process	mRNA processing
Z	0008380	biological_process	RNA splicing
Z	0030532	cellular_component	small nuclear ribonucleoprotein complex
Z	0034709	cellular_component	methylosome
Z	0034715	cellular_component	pICln-Sm protein complex
Z	0034719	cellular_component	SMN-Sm protein complex
Z	0036261	biological_process	7-methylguanosine cap hypermethylation
Z	0043229	cellular_component	intracellular organelle
Z	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
Z	0071005	cellular_component	U2-type precatalytic spliceosome
Z	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Z	0071011	cellular_component	precatalytic spliceosome
Z	0071013	cellular_component	catalytic step 2 spliceosome
Z	0097526	cellular_component	spliceosomal tri-snRNP complex
Z	1903241	biological_process	U2-type prespliceosome assembly

Functional Information from PROSITE/UniProt

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CedknVPYvfVrSKqaLG

Chain	Residue	Details
O	CYS73-GLY90

---

site_id	PS00436
Number of Residues	12
Details	PEROXIDASE_2 Peroxidases active site signature. TVrvARVmWHPS

Chain	Residue	Details
F	THR322-SER333

---

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cnv..CdcvVkdsinfldHingkkH

Chain	Residue	Details
N	CYS82-HIS104

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH

Chain	Residue	Details
w	PHE287-HIS293

---

site_id	PS01159
Number of Residues	26
Details	WW_DOMAIN_1 WW/rsp5/WWP domain signature. WvegitsegyhyYYdlisga.SQWEKP

Chain	Residue	Details
Q	TRP128-PRO153
Q	TRP169-PRO194

---

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgStFHRVIkdFMiQGG

Chain	Residue	Details
M	TYR60-GLY77

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LASAgfDrLILLWNV

Chain	Residue	Details
D	LEU81-VAL95
D	LEU124-SER138
D	VAL167-ILE181
D	ILE208-LEU222
D	ILE300-THR314
L	LEU229-PHE243
L	ILE364-MET378
F	LEU337-LEU351
F	ILE421-LEU435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q9CQI7

Chain	Residue	Details
1	LYS111
y	CYS73
y	CYS76
y	CYS86
y	CYS23
y	CYS26
y	CYS30
y	CYS33
y	CYS46
y	CYS49
y	CYS58
y	CYS61

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455

Chain	Residue	Details
1	TYR151
w	LYS1171
X	ARG147
P	SER789

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
1	LYS111
v	CYS677
v	GLU1205
N	LYS39
N	LYS55
N	LYS61
N	LYS70
N	LYS102
N	LYS123

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
z	SER236
z	SER255
v	THR426
h	LYS6
h	LYS8
S	LYS6
S	LYS8

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
z	LYS172
C	THR1428

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
y	SER95
R	LYS501
R	LYS509
R	LYS541
R	LYS543
R	LYS553
z	LYS221
v	LYS562
R	LYS331
R	LYS386
R	LYS388
R	LYS404
R	LYS408
R	LYS496

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	THR142

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Citrulline => ECO:0000250

Chain	Residue	Details
v	ARG157
P	SER596
P	SER598

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	SER194

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
v	THR203
K	LYS357
K	LYS371
K	LYS381
K	LYS415
K	LYS418

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	THR207
C	SER2135
H	LYS478

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
v	THR211
P	LYS648
P	LYS657
P	LYS684
P	LYS699
P	LYS709
P	LYS723
P	LYS749
P	LYS758
P	LYS775
P	LYS780
P	LYS791
P	LYS133
P	LYS277
P	LYS329
P	LYS336
P	LYS400
P	LYS414
P	LYS548

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q99NB9

Chain	Residue	Details
v	LYS214

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	THR223
P	LYS188

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	THR227

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q99NB9

Chain	Residue	Details
v	SER229

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:12105215

Chain	Residue	Details
v	THR244

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000305|PubMed:12105215

Chain	Residue	Details
v	THR248

---

site_id	SWS_FT_FI19
Number of Residues	5
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
v	THR257
v	THR261
v	THR278
v	THR303
v	THR313

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
v	THR267

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
v	THR273

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
v	SER287

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	THR296

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983

Chain	Residue	Details
v	THR299

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	SER322

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	THR326

---

site_id	SWS_FT_FI27
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
v	THR328

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	SER332

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692

Chain	Residue	Details
v	THR341

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
v	SER344

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692

Chain	Residue	Details
v	SER349

---

site_id	SWS_FT_FI32
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	THR350
v	THR436

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	THR354

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	SER400

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by DYRK1A => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
v	THR434

---

site_id	SWS_FT_FI36
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
v	SER488

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
v	LYS214

---

site_id	SWS_FT_FI38
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
v	LYS430

---

site_id	SWS_FT_FI39
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
v	LYS413

---