5O4Q
Crystal Structure of mutant M54L/M64L/M96L of Two-Domain Laccase from Streptomyces griseoflavus with 0.25 mM copper sulfate on growth medium
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| B | 0005507 | molecular_function | copper ion binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| C | 0005507 | molecular_function | copper ion binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| D | 0005507 | molecular_function | copper ion binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| E | 0005507 | molecular_function | copper ion binding |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| F | 0005507 | molecular_function | copper ion binding |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| G | 0005507 | molecular_function | copper ion binding |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| H | 0005507 | molecular_function | copper ion binding |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| I | 0005507 | molecular_function | copper ion binding |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| J | 0005507 | molecular_function | copper ion binding |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| K | 0005507 | molecular_function | copper ion binding |
| K | 0016491 | molecular_function | oxidoreductase activity |
| K | 0046872 | molecular_function | metal ion binding |
| K | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
| L | 0005507 | molecular_function | copper ion binding |
| L | 0016491 | molecular_function | oxidoreductase activity |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0052716 | molecular_function | hydroquinone:oxygen oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CU A 401 |
| Chain | Residue |
| A | HIS232 |
| A | CYS289 |
| A | HIS294 |
| A | MET299 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CU A 402 |
| Chain | Residue |
| A | HIS103 |
| A | HIS105 |
| A | HIS157 |
| B | HIS290 |
| B | HOH560 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue TRS A 403 |
| Chain | Residue |
| A | TYR230 |
| A | HOH529 |
| H | TYR230 |
| H | HOH549 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CU B 401 |
| Chain | Residue |
| B | HIS232 |
| B | CYS289 |
| B | HIS294 |
| B | MET299 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CU B 402 |
| Chain | Residue |
| B | HIS103 |
| B | HIS105 |
| B | HIS157 |
| C | HIS290 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue AZI B 403 |
| Chain | Residue |
| A | HOH519 |
| B | TYR230 |
| B | TYR231 |
| B | HIS294 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| B | LYS117 |
| B | VAL160 |
| B | GLY162 |
| B | THR163 |
| B | GLU164 |
| B | HOH543 |
| I | ASP97 |
| I | VAL98 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue CU C 401 |
| Chain | Residue |
| A | HIS290 |
| A | HOH555 |
| C | HIS103 |
| C | HIS105 |
| C | HIS157 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue CU C 402 |
| Chain | Residue |
| C | HIS232 |
| C | CYS289 |
| C | HIS294 |
| C | MET299 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue CU D 401 |
| Chain | Residue |
| D | HIS232 |
| D | CYS289 |
| D | HIS294 |
| D | MET299 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue CU D 402 |
| Chain | Residue |
| D | HIS103 |
| D | HIS105 |
| D | HIS157 |
| E | HIS290 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue FMT D 403 |
| Chain | Residue |
| D | GLY152 |
| D | VAL180 |
| D | ARG181 |
| D | ASP185 |
| D | ARG245 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue CU E 401 |
| Chain | Residue |
| E | HIS232 |
| E | CYS289 |
| E | HIS294 |
| E | MET299 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue CU E 402 |
| Chain | Residue |
| E | HIS103 |
| E | HIS105 |
| E | HIS157 |
| F | HIS290 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue AZI E 403 |
| Chain | Residue |
| E | ASP268 |
| F | ASN261 |
| F | LYS262 |
| F | ILE263 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue CU F 401 |
| Chain | Residue |
| D | HIS290 |
| F | HIS103 |
| F | HIS105 |
| F | HIS157 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue CU F 402 |
| Chain | Residue |
| F | HIS232 |
| F | CYS289 |
| F | HIS294 |
| F | MET299 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue CU G 401 |
| Chain | Residue |
| G | HIS232 |
| G | CYS289 |
| G | HIS294 |
| G | MET299 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue CU G 402 |
| Chain | Residue |
| G | HIS103 |
| G | HIS105 |
| G | HIS157 |
| H | HIS290 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue CU H 401 |
| Chain | Residue |
| H | HIS232 |
| H | CYS289 |
| H | HIS294 |
| H | MET299 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue CU H 402 |
| Chain | Residue |
| H | HIS103 |
| H | HIS105 |
| H | HIS157 |
| I | HIS290 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue AZI H 403 |
| Chain | Residue |
| H | TYR230 |
| H | TYR231 |
| H | HIS294 |
| H | HOH546 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue CU I 401 |
| Chain | Residue |
| I | HIS157 |
| G | HIS290 |
| G | HOH553 |
| I | HIS103 |
| I | HIS105 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue CU I 402 |
| Chain | Residue |
| I | HIS232 |
| I | CYS289 |
| I | HIS294 |
| I | MET299 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue CU J 401 |
| Chain | Residue |
| J | HIS232 |
| J | CYS289 |
| J | HIS294 |
| J | MET299 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue CU J 402 |
| Chain | Residue |
| J | HIS103 |
| J | HIS105 |
| J | HIS157 |
| K | HIS290 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue AZI J 403 |
| Chain | Residue |
| J | TYR230 |
| J | TYR231 |
| J | HIS294 |
| K | TYR231 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue TRS J 404 |
| Chain | Residue |
| E | ARG171 |
| E | TYR230 |
| E | HOH571 |
| J | TYR230 |
| J | HOH551 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue CU K 401 |
| Chain | Residue |
| K | HIS232 |
| K | CYS289 |
| K | HIS294 |
| K | MET299 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue CU K 402 |
| Chain | Residue |
| K | HIS103 |
| K | HIS105 |
| K | HIS157 |
| L | HIS290 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 K 403 |
| Chain | Residue |
| K | ARG58 |
| K | ALA60 |
| K | GLY61 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue CU L 401 |
| Chain | Residue |
| J | HIS290 |
| L | HIS103 |
| L | HIS105 |
| L | HIS157 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue CU L 402 |
| Chain | Residue |
| L | HIS232 |
| L | CYS289 |
| L | HIS294 |
| L | MET299 |
Functional Information from PROSITE/UniProt
| site_id | PS00080 |
| Number of Residues | 12 |
| Details | MULTICOPPER_OXIDASE2 Multicopper oxidases signature 2. HCHvqsHsdmGM |
| Chain | Residue | Details |
| A | HIS288-MET299 |
