5O49

Human FGF in complex with a covalent inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005007	molecular_function	fibroblast growth factor receptor activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005007	molecular_function	fibroblast growth factor receptor activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue 9K5 A 801

Chain	Residue
A	LEU484
A	VAL561
A	GLU562
A	TYR563
A	ALA564
A	LEU630
A	ASP641
A	HOH910
A	GLY485
A	GLU486
A	GLY487
A	PHE489
A	GLY490
A	VAL492
A	ALA512
A	LYS514

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 802

Chain	Residue
A	ARG570
A	ARG627
A	THR657
A	ASN659
A	ARG661
A	TRP666
A	HOH904

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 803

Chain	Residue
A	GLY539
A	LYS540
A	LYS618
A	HOH933

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 B 802

Chain	Residue
B	ARG570
B	ARG627
B	THR657
B	ASN659
B	ARG661
B	HOH901

---

site_id	AC5
Number of Residues	21
Details	binding site for Di-peptide 9K5 B 801 and LYS B 514

Chain	Residue
B	LEU484
B	GLY485
B	GLU486
B	PHE489
B	GLN491
B	VAL492
B	ALA512
B	VAL513
B	MET515
B	LEU528
B	GLU531
B	TYR558
B	VAL559
B	GLU562
B	TYR563
B	ALA564
B	LEU630
B	HOH904
B	HOH912
B	HOH926
B	HOH933

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK

Chain	Residue	Details
A	LEU484-LYS514

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS619-VAL631

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19665973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---