Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | ARG145 |
| A | GLN202 |
| A | ARG208 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | HOH651 |
| A | GLY156 |
| A | ALA157 |
| A | PHE158 |
| A | LYS159 |
| A | HOH605 |
| A | HOH621 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | LYS307 |
| A | TYR321 |
| A | EDO504 |
| A | HOH632 |
| A | HOH661 |
| B | SEP304 |
| B | SER308 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | TYR321 |
| A | GLU322 |
| A | GLU323 |
| A | EDO503 |
| A | HOH659 |
| B | ARG181 |
| B | THR184 |
| B | SEP304 |
| B | HOH634 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | LYS307 |
| A | SER308 |
| A | VAL309 |
| A | GLY311 |
| A | HOH625 |
| A | HOH627 |
| B | SER308 |
| B | EDO514 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | VAL361 |
| A | LYS366 |
| A | ILE386 |
| A | GLN388 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 507 |
| Chain | Residue |
| A | SEP304 |
| A | PHE305 |
| A | SER308 |
| A | EDO508 |
| B | LYS307 |
| B | TYR321 |
| B | EDO508 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 508 |
| Chain | Residue |
| A | ARG181 |
| A | LYS182 |
| A | SEP304 |
| A | EDO507 |
| A | HOH601 |
| B | TYR321 |
| B | GLU323 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 509 |
| Chain | Residue |
| A | HIS265 |
| A | SER395 |
| A | ILE396 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 510 |
| Chain | Residue |
| A | SER143 |
| A | ARG145 |
| A | ASP211 |
| A | HOH635 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 511 |
| Chain | Residue |
| A | ARG155 |
| A | GLY156 |
| A | PHE158 |
| A | LYS159 |
| A | THR160 |
| A | GLN179 |
| A | LYS182 |
| A | HOH641 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 512 |
| Chain | Residue |
| A | ILE272 |
| A | HIS273 |
| A | ARG274 |
| A | LEU295 |
| A | ALA298 |
| A | THR299 |
| A | HOH667 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 513 |
| Chain | Residue |
| A | ARG274 |
| A | THR312 |
| A | ALA333 |
| A | HOH611 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 514 |
| Chain | Residue |
| A | VAL161 |
| A | GLU228 |
| A | LEU229 |
| A | MET230 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 501 |
| Chain | Residue |
| A | ARG155 |
| B | ARG359 |
| B | SER363 |
| B | HOH626 |
| B | HOH633 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | ARG145 |
| B | ARG208 |
| B | TYR210 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | GLY156 |
| B | ALA157 |
| B | PHE158 |
| B | LYS159 |
| B | EDO510 |
| B | HOH610 |
| B | HOH615 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | GLY285 |
| B | PRO286 |
| B | THR287 |
| B | THR287 |
| B | GLY288 |
| B | GLY288 |
| B | TRP253 |
| B | ILE283 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| B | ARG274 |
| B | GLU323 |
| B | HIS324 |
| B | TYR325 |
| B | HOH614 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| B | ARG274 |
| B | LEU276 |
| B | THR312 |
| B | PHE315 |
| B | ALA333 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| B | GLU187 |
| B | GLU194 |
| B | THR299 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| A | EDO507 |
| B | MET320 |
| B | GLU322 |
| B | GLU323 |
| B | EDO515 |
| B | HOH605 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 509 |
| Chain | Residue |
| B | MET230 |
| B | HOH611 |
| B | HOH621 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 510 |
| Chain | Residue |
| B | GLY154 |
| B | ARG155 |
| B | LYS159 |
| B | SO4503 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 511 |
| Chain | Residue |
| B | GLU314 |
| B | HOH659 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 512 |
| Chain | Residue |
| A | SER252 |
| A | GLN256 |
| B | SER143 |
| B | HOH637 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 513 |
| Chain | Residue |
| B | VAL361 |
| B | GLY364 |
| B | ILE365 |
| B | ILE386 |
| B | GLN388 |
| site_id | AF1 |
| Number of Residues | 10 |
| Details | binding site for residue EDO B 514 |
| Chain | Residue |
| A | SER308 |
| A | ALA354 |
| A | EDO505 |
| A | HOH631 |
| B | LYS307 |
| B | SER308 |
| B | VAL309 |
| B | GLY311 |
| B | HOH659 |
| B | HOH670 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 515 |
| Chain | Residue |
| B | MET301 |
| B | LYS307 |
| B | EDO508 |
| B | HOH605 |
| B | HOH652 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 516 |
| Chain | Residue |
| B | ARG190 |
| B | LYS366 |
| B | ARG387 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 517 |
| Chain | Residue |
| B | LYS185 |
| B | GLN189 |
| B | LYS192 |
| B | GLU214 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 518 |
| Chain | Residue |
| B | ILE271 |
| B | ILE272 |
| B | HIS273 |
| B | ARG274 |
| B | ALA298 |
| B | THR299 |
| site_id | AF6 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 519 |
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKcdNIFI |
| Chain | Residue | Details |
| A | ILE271-ILE283 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q9JIH7","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9H4A3","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q9JIH7","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"33439774","evidenceCode":"ECO:0000269"}]} |
