Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5NZS

The structure of the COPI coat leaf in complex with the ArfGAP2 uncoating factor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0003729	molecular_function	mRNA binding
A	0005179	molecular_function	hormone activity
A	0005198	molecular_function	structural molecule activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0006886	biological_process	intracellular protein transport
A	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
A	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
A	0006891	biological_process	intra-Golgi vesicle-mediated transport
A	0007165	biological_process	signal transduction
A	0015031	biological_process	protein transport
A	0016192	biological_process	vesicle-mediated transport
A	0030117	cellular_component	membrane coat
A	0030126	cellular_component	COPI vesicle coat
A	0030137	cellular_component	COPI-coated vesicle
A	0030157	biological_process	pancreatic juice secretion
A	0030424	cellular_component	axon
A	0030426	cellular_component	growth cone
A	0030663	cellular_component	COPI-coated vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0044297	cellular_component	cell body
A	0099612	biological_process	protein localization to axon
A	1902463	biological_process	protein localization to cell leading edge
B	0000139	cellular_component	Golgi membrane
B	0005198	molecular_function	structural molecule activity
B	0005737	cellular_component	cytoplasm
B	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
B	0005794	cellular_component	Golgi apparatus
B	0005798	cellular_component	Golgi-associated vesicle
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006886	biological_process	intracellular protein transport
B	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
B	0006891	biological_process	intra-Golgi vesicle-mediated transport
B	0015031	biological_process	protein transport
B	0016192	biological_process	vesicle-mediated transport
B	0030117	cellular_component	membrane coat
B	0030126	cellular_component	COPI vesicle coat
B	0030137	cellular_component	COPI-coated vesicle
B	0030663	cellular_component	COPI-coated vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
C	0000139	cellular_component	Golgi membrane
C	0005080	molecular_function	protein kinase C binding
C	0005198	molecular_function	structural molecule activity
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0006886	biological_process	intracellular protein transport
C	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
C	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
C	0006891	biological_process	intra-Golgi vesicle-mediated transport
C	0015031	biological_process	protein transport
C	0016192	biological_process	vesicle-mediated transport
C	0030117	cellular_component	membrane coat
C	0030126	cellular_component	COPI vesicle coat
C	0030663	cellular_component	COPI-coated vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
D	0000139	cellular_component	Golgi membrane
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005794	cellular_component	Golgi apparatus
D	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
D	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
D	0008344	biological_process	adult locomotory behavior
D	0015031	biological_process	protein transport
D	0016192	biological_process	vesicle-mediated transport
D	0021691	biological_process	cerebellar Purkinje cell layer maturation
D	0030126	cellular_component	COPI vesicle coat
D	0030137	cellular_component	COPI-coated vesicle
D	0030663	cellular_component	COPI-coated vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0043473	biological_process	pigmentation
D	0048193	biological_process	Golgi vesicle transport
D	0051645	biological_process	Golgi localization
F	0000166	molecular_function	nucleotide binding
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006886	biological_process	intracellular protein transport
F	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
F	0006893	biological_process	Golgi to plasma membrane transport
F	0010636	biological_process	positive regulation of mitochondrial fusion
F	0015031	biological_process	protein transport
F	0016192	biological_process	vesicle-mediated transport
F	0016236	biological_process	macroautophagy
F	0016787	molecular_function	hydrolase activity
F	0019217	biological_process	regulation of fatty acid metabolic process
F	0044232	cellular_component	organelle membrane contact site
F	0048193	biological_process	Golgi vesicle transport
F	0090141	biological_process	positive regulation of mitochondrial fission
F	1903292	biological_process	protein localization to Golgi membrane
F	1903358	biological_process	regulation of Golgi organization
G	0000139	cellular_component	Golgi membrane
G	0005198	molecular_function	structural molecule activity
G	0005783	cellular_component	endoplasmic reticulum
G	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0006886	biological_process	intracellular protein transport
G	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
G	0006891	biological_process	intra-Golgi vesicle-mediated transport
G	0009306	biological_process	protein secretion
G	0015031	biological_process	protein transport
G	0016192	biological_process	vesicle-mediated transport
G	0030117	cellular_component	membrane coat
G	0030126	cellular_component	COPI vesicle coat
G	0030663	cellular_component	COPI-coated vesicle membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0051683	biological_process	establishment of Golgi localization
G	0072384	biological_process	organelle transport along microtubule
K	0000139	cellular_component	Golgi membrane
K	0005198	molecular_function	structural molecule activity
K	0005783	cellular_component	endoplasmic reticulum
K	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
K	0005794	cellular_component	Golgi apparatus
K	0005829	cellular_component	cytosol
K	0006886	biological_process	intracellular protein transport
K	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
K	0006891	biological_process	intra-Golgi vesicle-mediated transport
K	0009306	biological_process	protein secretion
K	0015031	biological_process	protein transport
K	0016192	biological_process	vesicle-mediated transport
K	0030117	cellular_component	membrane coat
K	0030126	cellular_component	COPI vesicle coat
K	0030663	cellular_component	COPI-coated vesicle membrane
K	0031410	cellular_component	cytoplasmic vesicle
K	0051683	biological_process	establishment of Golgi localization
K	0072384	biological_process	organelle transport along microtubule
L	0000139	cellular_component	Golgi membrane
L	0003674	molecular_function	molecular_function
L	0005737	cellular_component	cytoplasm
L	0006886	biological_process	intracellular protein transport
L	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
L	0006891	biological_process	intra-Golgi vesicle-mediated transport
L	0015031	biological_process	protein transport
L	0016192	biological_process	vesicle-mediated transport
L	0030117	cellular_component	membrane coat
L	0030126	cellular_component	COPI vesicle coat
L	0030663	cellular_component	COPI-coated vesicle membrane
L	0031410	cellular_component	cytoplasmic vesicle
M	0000166	molecular_function	nucleotide binding
M	0003924	molecular_function	GTPase activity
M	0003925	molecular_function	G protein activity
M	0005515	molecular_function	protein binding
M	0005525	molecular_function	GTP binding
M	0005737	cellular_component	cytoplasm
M	0005794	cellular_component	Golgi apparatus
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006886	biological_process	intracellular protein transport
M	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
M	0006893	biological_process	Golgi to plasma membrane transport
M	0010636	biological_process	positive regulation of mitochondrial fusion
M	0015031	biological_process	protein transport
M	0016192	biological_process	vesicle-mediated transport
M	0016236	biological_process	macroautophagy
M	0016787	molecular_function	hydrolase activity
M	0019217	biological_process	regulation of fatty acid metabolic process
M	0044232	cellular_component	organelle membrane contact site
M	0048193	biological_process	Golgi vesicle transport
M	0090141	biological_process	positive regulation of mitochondrial fission
M	1903292	biological_process	protein localization to Golgi membrane
M	1903358	biological_process	regulation of Golgi organization
P	0000139	cellular_component	Golgi membrane
P	0005096	molecular_function	GTPase activator activity
P	0005737	cellular_component	cytoplasm
P	0005794	cellular_component	Golgi apparatus
P	0008270	molecular_function	zinc ion binding
P	0015031	biological_process	protein transport
P	0016192	biological_process	vesicle-mediated transport
P	0046872	molecular_function	metal ion binding
P	0048205	biological_process	COPI coating of Golgi vesicle
R	0000166	molecular_function	nucleotide binding
R	0003924	molecular_function	GTPase activity
R	0003925	molecular_function	G protein activity
R	0005515	molecular_function	protein binding
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0005794	cellular_component	Golgi apparatus
R	0005829	cellular_component	cytosol
R	0005886	cellular_component	plasma membrane
R	0006886	biological_process	intracellular protein transport
R	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
R	0006893	biological_process	Golgi to plasma membrane transport
R	0010636	biological_process	positive regulation of mitochondrial fusion
R	0015031	biological_process	protein transport
R	0016192	biological_process	vesicle-mediated transport
R	0016236	biological_process	macroautophagy
R	0016787	molecular_function	hydrolase activity
R	0019217	biological_process	regulation of fatty acid metabolic process
R	0044232	cellular_component	organelle membrane contact site
R	0048193	biological_process	Golgi vesicle transport
R	0090141	biological_process	positive regulation of mitochondrial fission
R	1903292	biological_process	protein localization to Golgi membrane
R	1903358	biological_process	regulation of Golgi organization
Z	0000139	cellular_component	Golgi membrane
Z	0003674	molecular_function	molecular_function
Z	0005737	cellular_component	cytoplasm
Z	0006886	biological_process	intracellular protein transport
Z	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Z	0006891	biological_process	intra-Golgi vesicle-mediated transport
Z	0015031	biological_process	protein transport
Z	0016192	biological_process	vesicle-mediated transport
Z	0030117	cellular_component	membrane coat
Z	0030126	cellular_component	COPI vesicle coat
Z	0030663	cellular_component	COPI-coated vesicle membrane
Z	0031410	cellular_component	cytoplasmic vesicle

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VVSAslDqTVRVWDI

Chain	Residue	Details
A	VAL150-ILE164

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. VVYKssidLYF

Chain	Residue	Details
Z	VAL67-PHE77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	Peptide: {"description":"Proxenin","featureId":"PRO_0000327497"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Peptide: {"description":"Xenin","featureId":"PRO_0000327498"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	69
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	69
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	69
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	70
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	71
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	69
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P53621","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	109
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	73
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	69
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	73
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	37
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	37
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	38
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	35
Details	Repeat: {"description":"WD 8"}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	37
Details	Repeat: {"description":"WD 9"}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P35606","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P48444","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P48444","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	39
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20601958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	530
Details	Region: {"description":"Interaction with ZNF289/ARFGAP2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	116
Details	Domain: {"description":"Arf-GAP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00288","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	23
Details	Zinc finger: {"description":"C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00288","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q8N6H7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)