5NX8
Crystal structure of Neanderthal Adenylosuccinate Lyase (ADSL)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004018 | molecular_function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006167 | biological_process | AMP biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| A | 0070626 | molecular_function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004018 | molecular_function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006167 | biological_process | AMP biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| B | 0070626 | molecular_function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004018 | molecular_function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006164 | biological_process | purine nucleotide biosynthetic process |
| C | 0006167 | biological_process | AMP biosynthetic process |
| C | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| C | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| C | 0070626 | molecular_function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004018 | molecular_function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006164 | biological_process | purine nucleotide biosynthetic process |
| D | 0006167 | biological_process | AMP biosynthetic process |
| D | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| D | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| D | 0070626 | molecular_function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 501 |
| Chain | Residue |
| A | LEU55 |
| A | PRO56 |
| A | HOH699 |
| A | HOH835 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue PEG A 502 |
| Chain | Residue |
| A | VAL247 |
| A | GLU250 |
| A | HOH604 |
| A | HOH669 |
| B | MET181 |
| A | LEU121 |
| A | ASP192 |
| A | LEU193 |
| A | ARG194 |
| A | PHE236 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | ASP120 |
| A | ARG337 |
| A | ARG338 |
| A | LEU341 |
| A | ALA342 |
| A | HOH635 |
| A | HOH640 |
| A | HOH643 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | ASP216 |
| A | HOH657 |
| B | GLY451 |
| B | ARG452 |
| B | GLN455 |
| B | HOH668 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 505 |
| Chain | Residue |
| A | GLY200 |
| A | THR201 |
| A | SER207 |
| A | HOH778 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 506 |
| Chain | Residue |
| A | THR111 |
| A | TYR114 |
| A | ARG196 |
| A | LYS199 |
| A | GLY200 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| B | ASP120 |
| B | ARG337 |
| B | ARG338 |
| B | LEU341 |
| B | ALA342 |
| B | HOH638 |
| B | HOH644 |
| B | HOH659 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 502 |
| Chain | Residue |
| B | THR111 |
| B | ARG196 |
| B | LYS199 |
| B | GLY200 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 503 |
| Chain | Residue |
| B | GLY200 |
| B | THR201 |
| B | ALA206 |
| B | SER207 |
| B | HOH763 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue PEG C 501 |
| Chain | Residue |
| A | GLN51 |
| A | HOH630 |
| C | HIS217 |
| C | LYS218 |
| C | GLN221 |
| C | HOH602 |
| site_id | AD2 |
| Number of Residues | 10 |
| Details | binding site for residue PEG C 502 |
| Chain | Residue |
| C | LEU121 |
| C | ASP192 |
| C | LEU193 |
| C | ARG194 |
| C | PHE236 |
| C | VAL247 |
| C | GLU250 |
| C | HOH601 |
| C | HOH633 |
| D | MET181 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| C | ASP120 |
| C | ARG337 |
| C | ARG338 |
| C | LEU341 |
| C | ALA342 |
| C | HOH648 |
| C | HOH662 |
| C | HOH691 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| C | ASP216 |
| C | HOH635 |
| D | GLY451 |
| D | GLN455 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 505 |
| Chain | Residue |
| C | GLY200 |
| C | THR201 |
| C | SER207 |
| C | HOH728 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 506 |
| Chain | Residue |
| C | THR111 |
| C | ARG196 |
| C | LYS199 |
| C | GLY200 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 502 |
| Chain | Residue |
| D | ASP120 |
| D | ILE123 |
| D | ARG337 |
| D | ARG338 |
| D | LEU341 |
| D | ALA342 |
| D | HOH641 |
| D | HOH692 |
| D | HOH696 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 503 |
| Chain | Residue |
| C | GLY451 |
| C | GLN455 |
| D | ARG83 |
| D | ASP216 |
| D | HOH647 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue CL D 504 |
| Chain | Residue |
| D | THR111 |
| D | TYR114 |
| D | ARG196 |
| D | LYS199 |
| D | GLY200 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 505 |
| Chain | Residue |
| D | GLY200 |
| D | THR201 |
| D | ALA206 |
| D | SER207 |
Functional Information from PROSITE/UniProt
| site_id | PS00163 |
| Number of Residues | 10 |
| Details | FUMARATE_LYASES Fumarate lyases signature. GSsaMpYKrN |
| Chain | Residue | Details |
| A | GLY288-ASN297 |
