5NVA
Substrate-bound outward-open state of a Na+-coupled sialic acid symporter reveals a novel Na+-site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0015293 | molecular_function | symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071702 | biological_process | obsolete organic substance transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 107 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:29717135, ECO:0007744|PDB:5NV9, ECO:0007744|PDB:5NVA |
| Chain | Residue | Details |
| A | MET1-GLY7 | |
| A | SER60-TRP76 | |
| A | LEU145-ASP154 | |
| A | ILE200-THR235 | |
| A | SER293-PRO325 | |
| A | LEU397-ILE403 | |
| A | SER454-ASN457 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 266 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:29717135, ECO:0007744|PDB:5NV9, ECO:0007744|PDB:5NVA |
| Chain | Residue | Details |
| A | PHE8-SER29 | |
| A | LYS375-VAL396 | |
| A | TRP404-PHE427 | |
| A | ALA433-GLY453 | |
| A | PHE458-LEU479 | |
| A | GLY47-LEU59 | |
| A | THR77-VAL92 | |
| A | ASP117-VAL144 | |
| A | PRO155-MET172 | |
| A | ILE175-MET199 | |
| A | ILE236-THR252 | |
| A | THR273-GLY292 | |
| A | ILE326-ASN356 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 96 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29717135, ECO:0007744|PDB:5NV9, ECO:0007744|PDB:5NVA |
| Chain | Residue | Details |
| A | LYS30-PRO46 | |
| A | PHE93-PHE116 | |
| A | GLY173-GLY174 | |
| A | ALA253-ARG272 | |
| A | SER357-MET374 | |
| A | VAL428-ASN432 | |
| A | PHE480-ASN496 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29717135, ECO:0007744|PDB:5NV9, ECO:0007744|PDB:5NVA |
| Chain | Residue | Details |
| A | ALA56 | |
| A | LEU59 | |
| A | ASP182 | |
| A | ALA339 | |
| A | SER342 | |
| A | SER343 | |
| A | SER345 | |
| A | SER346 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:29717135, ECO:0007744|PDB:5NV9, ECO:0007744|PDB:5NVA |
| Chain | Residue | Details |
| A | THR58 | |
| A | SER60 | |
| A | THR63 | |
| A | GLN82 | |
| A | ARG135 |
