5NSQ
Structure of Leucyl aminopeptidase from Trypanosoma brucei in complex with Actinonin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0019538 | biological_process | protein metabolic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0019538 | biological_process | protein metabolic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0019538 | biological_process | protein metabolic process |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070006 | molecular_function | metalloaminopeptidase activity |
| D | 0004177 | molecular_function | aminopeptidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0019538 | biological_process | protein metabolic process |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070006 | molecular_function | metalloaminopeptidase activity |
| E | 0004177 | molecular_function | aminopeptidase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006508 | biological_process | proteolysis |
| E | 0008233 | molecular_function | peptidase activity |
| E | 0019538 | biological_process | protein metabolic process |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070006 | molecular_function | metalloaminopeptidase activity |
| F | 0004177 | molecular_function | aminopeptidase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006508 | biological_process | proteolysis |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0019538 | biological_process | protein metabolic process |
| F | 0030145 | molecular_function | manganese ion binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 601 |
| Chain | Residue |
| A | LYS289 |
| A | ASP294 |
| A | ASP312 |
| A | GLU373 |
| A | MN602 |
| A | BB2603 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 602 |
| Chain | Residue |
| A | MN601 |
| A | BB2603 |
| A | ASP294 |
| A | ASP371 |
| A | GLU373 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue BB2 A 603 |
| Chain | Residue |
| A | LYS289 |
| A | ASP294 |
| A | LYS301 |
| A | ASP371 |
| A | GLU373 |
| A | LEU402 |
| A | GLY404 |
| A | ALA405 |
| A | ILE408 |
| A | LEU463 |
| A | MN601 |
| A | MN602 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MN B 601 |
| Chain | Residue |
| B | LYS289 |
| B | ASP294 |
| B | ASP312 |
| B | GLU373 |
| B | MN602 |
| B | BB2603 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 602 |
| Chain | Residue |
| B | ASP294 |
| B | ASP371 |
| B | GLU373 |
| B | MN601 |
| B | BB2603 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue BB2 B 603 |
| Chain | Residue |
| B | LYS289 |
| B | ASP294 |
| B | LYS301 |
| B | ASN369 |
| B | ASP371 |
| B | GLU373 |
| B | LEU402 |
| B | GLY404 |
| B | ALA405 |
| B | ILE408 |
| B | MN601 |
| B | MN602 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MN C 601 |
| Chain | Residue |
| C | LYS289 |
| C | ASP294 |
| C | ASP312 |
| C | GLU373 |
| C | MN602 |
| C | BB2603 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MN C 602 |
| Chain | Residue |
| C | ASP294 |
| C | ASP371 |
| C | GLU373 |
| C | MN601 |
| C | BB2603 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | binding site for residue BB2 C 603 |
| Chain | Residue |
| C | LYS289 |
| C | ASP294 |
| C | LYS301 |
| C | ASP371 |
| C | GLU373 |
| C | LEU402 |
| C | GLY404 |
| C | ALA405 |
| C | ILE408 |
| C | MN601 |
| C | MN602 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue MN D 601 |
| Chain | Residue |
| D | LYS289 |
| D | ASP294 |
| D | ASP312 |
| D | GLU373 |
| D | MN602 |
| D | BB2603 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue MN D 602 |
| Chain | Residue |
| D | ASP294 |
| D | ASP371 |
| D | GLU373 |
| D | MN601 |
| D | BB2603 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for residue BB2 D 603 |
| Chain | Residue |
| D | LYS289 |
| D | ASP294 |
| D | LYS301 |
| D | ASP371 |
| D | GLU373 |
| D | LEU402 |
| D | GLY404 |
| D | ILE408 |
| D | MN601 |
| D | MN602 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue MN E 601 |
| Chain | Residue |
| E | LYS289 |
| E | ASP294 |
| E | ASP312 |
| E | GLU373 |
| E | MN602 |
| E | BB2603 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue MN E 602 |
| Chain | Residue |
| E | BB2603 |
| E | ASP294 |
| E | ASP371 |
| E | GLU373 |
| E | MN601 |
| site_id | AD6 |
| Number of Residues | 11 |
| Details | binding site for residue BB2 E 603 |
| Chain | Residue |
| E | LYS289 |
| E | ASP294 |
| E | LYS301 |
| E | ASN369 |
| E | ASP371 |
| E | GLU373 |
| E | LEU402 |
| E | GLY404 |
| E | ALA405 |
| E | MN601 |
| E | MN602 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue MN F 601 |
| Chain | Residue |
| F | LYS289 |
| F | ASP294 |
| F | ASP312 |
| F | GLU373 |
| F | MN602 |
| F | BB2603 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue MN F 602 |
| Chain | Residue |
| F | ASP294 |
| F | ASP371 |
| F | GLU373 |
| F | MN601 |
| F | BB2603 |
| site_id | AD9 |
| Number of Residues | 10 |
| Details | binding site for residue BB2 F 603 |
| Chain | Residue |
| F | LYS289 |
| F | ASP294 |
| F | LYS301 |
| F | ASP371 |
| F | GLU373 |
| F | LEU402 |
| F | GLY404 |
| F | ALA405 |
| F | MN601 |
| F | MN602 |
Functional Information from PROSITE/UniProt
| site_id | PS00631 |
| Number of Residues | 8 |
| Details | CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRI |
| Chain | Residue | Details |
| A | ASN369-ILE376 |
