5NSM
unliganded Structure of Leucyl aminopeptidase from Trypanosoma brucei
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019538 | biological_process | protein metabolic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019538 | biological_process | protein metabolic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0019538 | biological_process | protein metabolic process |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070006 | molecular_function | metalloaminopeptidase activity |
| D | 0004177 | molecular_function | aminopeptidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0019538 | biological_process | protein metabolic process |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070006 | molecular_function | metalloaminopeptidase activity |
| E | 0004177 | molecular_function | aminopeptidase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006508 | biological_process | proteolysis |
| E | 0008233 | molecular_function | peptidase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0019538 | biological_process | protein metabolic process |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070006 | molecular_function | metalloaminopeptidase activity |
| F | 0004177 | molecular_function | aminopeptidase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006508 | biological_process | proteolysis |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0019538 | biological_process | protein metabolic process |
| F | 0030145 | molecular_function | manganese ion binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070006 | molecular_function | metalloaminopeptidase activity |
| G | 0004177 | molecular_function | aminopeptidase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006508 | biological_process | proteolysis |
| G | 0008233 | molecular_function | peptidase activity |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0019538 | biological_process | protein metabolic process |
| G | 0030145 | molecular_function | manganese ion binding |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0070006 | molecular_function | metalloaminopeptidase activity |
| H | 0004177 | molecular_function | aminopeptidase activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006508 | biological_process | proteolysis |
| H | 0008233 | molecular_function | peptidase activity |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0019538 | biological_process | protein metabolic process |
| H | 0030145 | molecular_function | manganese ion binding |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0070006 | molecular_function | metalloaminopeptidase activity |
| I | 0004177 | molecular_function | aminopeptidase activity |
| I | 0005515 | molecular_function | protein binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0006508 | biological_process | proteolysis |
| I | 0008233 | molecular_function | peptidase activity |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0019538 | biological_process | protein metabolic process |
| I | 0030145 | molecular_function | manganese ion binding |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0070006 | molecular_function | metalloaminopeptidase activity |
| J | 0004177 | molecular_function | aminopeptidase activity |
| J | 0005515 | molecular_function | protein binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0006508 | biological_process | proteolysis |
| J | 0008233 | molecular_function | peptidase activity |
| J | 0016787 | molecular_function | hydrolase activity |
| J | 0019538 | biological_process | protein metabolic process |
| J | 0030145 | molecular_function | manganese ion binding |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0070006 | molecular_function | metalloaminopeptidase activity |
| K | 0004177 | molecular_function | aminopeptidase activity |
| K | 0005515 | molecular_function | protein binding |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0006508 | biological_process | proteolysis |
| K | 0008233 | molecular_function | peptidase activity |
| K | 0016787 | molecular_function | hydrolase activity |
| K | 0019538 | biological_process | protein metabolic process |
| K | 0030145 | molecular_function | manganese ion binding |
| K | 0046872 | molecular_function | metal ion binding |
| K | 0070006 | molecular_function | metalloaminopeptidase activity |
| L | 0004177 | molecular_function | aminopeptidase activity |
| L | 0005515 | molecular_function | protein binding |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006508 | biological_process | proteolysis |
| L | 0008233 | molecular_function | peptidase activity |
| L | 0016787 | molecular_function | hydrolase activity |
| L | 0019538 | biological_process | protein metabolic process |
| L | 0030145 | molecular_function | manganese ion binding |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue BCT A 601 |
| Chain | Residue |
| A | LYS289 |
| A | ALA372 |
| A | GLU373 |
| A | GLY374 |
| A | ARG375 |
| A | LEU402 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 602 |
| Chain | Residue |
| A | MN603 |
| A | HOH752 |
| A | ASP294 |
| A | ASP371 |
| A | GLU373 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 603 |
| Chain | Residue |
| A | LYS289 |
| A | ASP294 |
| A | ASP312 |
| A | GLU373 |
| A | MN602 |
| A | HOH708 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue BCT B 601 |
| Chain | Residue |
| B | LYS289 |
| B | ALA372 |
| B | GLU373 |
| B | GLY374 |
| B | ARG375 |
| B | LEU402 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 602 |
| Chain | Residue |
| B | ASP294 |
| B | ASP371 |
| B | GLU373 |
| B | MN603 |
| B | HOH740 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 603 |
| Chain | Residue |
| B | LYS289 |
| B | ASP294 |
| B | ASP312 |
| B | GLU373 |
| B | MN602 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue BCT C 601 |
| Chain | Residue |
| C | LYS289 |
| C | ALA372 |
| C | GLU373 |
| C | GLY374 |
| C | ARG375 |
| C | LEU402 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MN C 602 |
| Chain | Residue |
| C | ASP294 |
| C | ASP371 |
| C | GLU373 |
| C | MN603 |
| C | HOH751 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue MN C 603 |
| Chain | Residue |
| C | LYS289 |
| C | ASP294 |
| C | ASP312 |
| C | GLU373 |
| C | MN602 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue BCT D 601 |
| Chain | Residue |
| D | LYS289 |
| D | ALA372 |
| D | GLU373 |
| D | GLY374 |
| D | ARG375 |
| D | LEU402 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue MN D 602 |
| Chain | Residue |
| D | ASP294 |
| D | ASP371 |
| D | GLU373 |
| D | MN603 |
| D | HOH758 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue MN D 603 |
| Chain | Residue |
| D | LYS289 |
| D | ASP294 |
| D | ASP312 |
| D | GLU373 |
| D | MN602 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue BCT E 601 |
| Chain | Residue |
| E | LYS289 |
| E | ALA372 |
| E | GLU373 |
| E | GLY374 |
| E | ARG375 |
| E | LEU402 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue MN E 602 |
| Chain | Residue |
| E | ASP294 |
| E | ASP371 |
| E | GLU373 |
| E | MN603 |
| E | HOH754 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue MN E 603 |
| Chain | Residue |
| E | LYS289 |
| E | ASP294 |
| E | ASP312 |
| E | GLU373 |
| E | MN602 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue BCT F 601 |
| Chain | Residue |
| F | LYS289 |
| F | ALA372 |
| F | GLU373 |
| F | GLY374 |
| F | ARG375 |
| F | LEU402 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue MN F 602 |
| Chain | Residue |
| F | ASP294 |
| F | ASP371 |
| F | GLU373 |
| F | MN603 |
| F | HOH724 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue MN F 603 |
| Chain | Residue |
| F | LYS289 |
| F | ASP294 |
| F | ASP312 |
| F | GLU373 |
| F | MN602 |
| F | HOH724 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue BCT G 601 |
| Chain | Residue |
| G | ALA372 |
| G | GLU373 |
| G | GLY374 |
| G | ARG375 |
| G | LEU402 |
| G | LYS289 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue MN G 602 |
| Chain | Residue |
| G | ASP294 |
| G | ASP371 |
| G | GLU373 |
| G | MN603 |
| G | HOH754 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue MN G 603 |
| Chain | Residue |
| G | LYS289 |
| G | ASP294 |
| G | ASP312 |
| G | GLU373 |
| G | MN602 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue BCT H 601 |
| Chain | Residue |
| H | LYS289 |
| H | ALA372 |
| H | GLU373 |
| H | GLY374 |
| H | ARG375 |
| H | LEU402 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue MN H 602 |
| Chain | Residue |
| H | ASP294 |
| H | ASP371 |
| H | GLU373 |
| H | MN603 |
| H | HOH747 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue MN H 603 |
| Chain | Residue |
| H | LYS289 |
| H | ASP294 |
| H | ASP312 |
| H | GLU373 |
| H | MN602 |
| H | HOH739 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue BCT I 601 |
| Chain | Residue |
| I | LYS289 |
| I | ALA372 |
| I | GLU373 |
| I | GLY374 |
| I | ARG375 |
| I | LEU402 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue MN I 602 |
| Chain | Residue |
| I | ASP294 |
| I | ASP371 |
| I | GLU373 |
| I | MN603 |
| I | HOH744 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue MN I 603 |
| Chain | Residue |
| I | LYS289 |
| I | ASP294 |
| I | ASP312 |
| I | GLU373 |
| I | MN602 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue BCT J 601 |
| Chain | Residue |
| J | LYS289 |
| J | ALA372 |
| J | GLU373 |
| J | GLY374 |
| J | ARG375 |
| J | LEU402 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue MN J 602 |
| Chain | Residue |
| J | ASP294 |
| J | ASP371 |
| J | GLU373 |
| J | MN603 |
| J | HOH789 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue MN J 603 |
| Chain | Residue |
| J | LYS289 |
| J | ASP294 |
| J | ASP312 |
| J | GLU373 |
| J | MN602 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue BCT K 601 |
| Chain | Residue |
| K | LYS289 |
| K | ALA372 |
| K | GLU373 |
| K | GLY374 |
| K | ARG375 |
| K | LEU402 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue MN K 602 |
| Chain | Residue |
| K | ASP294 |
| K | ASP371 |
| K | GLU373 |
| K | MN603 |
| K | HOH767 |
| site_id | AF6 |
| Number of Residues | 5 |
| Details | binding site for residue MN K 603 |
| Chain | Residue |
| K | LYS289 |
| K | ASP294 |
| K | ASP312 |
| K | GLU373 |
| K | MN602 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue BCT L 601 |
| Chain | Residue |
| L | LYS289 |
| L | ALA372 |
| L | GLU373 |
| L | GLY374 |
| L | ARG375 |
| L | LEU402 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue MN L 602 |
| Chain | Residue |
| L | ASP294 |
| L | ASP371 |
| L | GLU373 |
| L | MN603 |
| L | HOH758 |
| site_id | AF9 |
| Number of Residues | 5 |
| Details | binding site for residue MN L 603 |
| Chain | Residue |
| L | LYS289 |
| L | ASP294 |
| L | ASP312 |
| L | GLU373 |
| L | MN602 |
Functional Information from PROSITE/UniProt
| site_id | PS00631 |
| Number of Residues | 8 |
| Details | CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRI |
| Chain | Residue | Details |
| A | ASN369-ILE376 |
