5NSM
unliganded Structure of Leucyl aminopeptidase from Trypanosoma brucei
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004177 | molecular_function | aminopeptidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0006508 | biological_process | proteolysis |
A | 0008233 | molecular_function | peptidase activity |
A | 0019538 | biological_process | protein metabolic process |
A | 0030145 | molecular_function | manganese ion binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0070006 | molecular_function | metalloaminopeptidase activity |
B | 0004177 | molecular_function | aminopeptidase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0006508 | biological_process | proteolysis |
B | 0008233 | molecular_function | peptidase activity |
B | 0019538 | biological_process | protein metabolic process |
B | 0030145 | molecular_function | manganese ion binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0070006 | molecular_function | metalloaminopeptidase activity |
C | 0004177 | molecular_function | aminopeptidase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0006508 | biological_process | proteolysis |
C | 0008233 | molecular_function | peptidase activity |
C | 0019538 | biological_process | protein metabolic process |
C | 0030145 | molecular_function | manganese ion binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0070006 | molecular_function | metalloaminopeptidase activity |
D | 0004177 | molecular_function | aminopeptidase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0006508 | biological_process | proteolysis |
D | 0008233 | molecular_function | peptidase activity |
D | 0019538 | biological_process | protein metabolic process |
D | 0030145 | molecular_function | manganese ion binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0070006 | molecular_function | metalloaminopeptidase activity |
E | 0004177 | molecular_function | aminopeptidase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005737 | cellular_component | cytoplasm |
E | 0006508 | biological_process | proteolysis |
E | 0008233 | molecular_function | peptidase activity |
E | 0019538 | biological_process | protein metabolic process |
E | 0030145 | molecular_function | manganese ion binding |
E | 0046872 | molecular_function | metal ion binding |
E | 0070006 | molecular_function | metalloaminopeptidase activity |
F | 0004177 | molecular_function | aminopeptidase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005737 | cellular_component | cytoplasm |
F | 0006508 | biological_process | proteolysis |
F | 0008233 | molecular_function | peptidase activity |
F | 0019538 | biological_process | protein metabolic process |
F | 0030145 | molecular_function | manganese ion binding |
F | 0046872 | molecular_function | metal ion binding |
F | 0070006 | molecular_function | metalloaminopeptidase activity |
G | 0004177 | molecular_function | aminopeptidase activity |
G | 0005515 | molecular_function | protein binding |
G | 0005737 | cellular_component | cytoplasm |
G | 0006508 | biological_process | proteolysis |
G | 0008233 | molecular_function | peptidase activity |
G | 0019538 | biological_process | protein metabolic process |
G | 0030145 | molecular_function | manganese ion binding |
G | 0046872 | molecular_function | metal ion binding |
G | 0070006 | molecular_function | metalloaminopeptidase activity |
H | 0004177 | molecular_function | aminopeptidase activity |
H | 0005515 | molecular_function | protein binding |
H | 0005737 | cellular_component | cytoplasm |
H | 0006508 | biological_process | proteolysis |
H | 0008233 | molecular_function | peptidase activity |
H | 0019538 | biological_process | protein metabolic process |
H | 0030145 | molecular_function | manganese ion binding |
H | 0046872 | molecular_function | metal ion binding |
H | 0070006 | molecular_function | metalloaminopeptidase activity |
I | 0004177 | molecular_function | aminopeptidase activity |
I | 0005515 | molecular_function | protein binding |
I | 0005737 | cellular_component | cytoplasm |
I | 0006508 | biological_process | proteolysis |
I | 0008233 | molecular_function | peptidase activity |
I | 0019538 | biological_process | protein metabolic process |
I | 0030145 | molecular_function | manganese ion binding |
I | 0046872 | molecular_function | metal ion binding |
I | 0070006 | molecular_function | metalloaminopeptidase activity |
J | 0004177 | molecular_function | aminopeptidase activity |
J | 0005515 | molecular_function | protein binding |
J | 0005737 | cellular_component | cytoplasm |
J | 0006508 | biological_process | proteolysis |
J | 0008233 | molecular_function | peptidase activity |
J | 0019538 | biological_process | protein metabolic process |
J | 0030145 | molecular_function | manganese ion binding |
J | 0046872 | molecular_function | metal ion binding |
J | 0070006 | molecular_function | metalloaminopeptidase activity |
K | 0004177 | molecular_function | aminopeptidase activity |
K | 0005515 | molecular_function | protein binding |
K | 0005737 | cellular_component | cytoplasm |
K | 0006508 | biological_process | proteolysis |
K | 0008233 | molecular_function | peptidase activity |
K | 0019538 | biological_process | protein metabolic process |
K | 0030145 | molecular_function | manganese ion binding |
K | 0046872 | molecular_function | metal ion binding |
K | 0070006 | molecular_function | metalloaminopeptidase activity |
L | 0004177 | molecular_function | aminopeptidase activity |
L | 0005515 | molecular_function | protein binding |
L | 0005737 | cellular_component | cytoplasm |
L | 0006508 | biological_process | proteolysis |
L | 0008233 | molecular_function | peptidase activity |
L | 0019538 | biological_process | protein metabolic process |
L | 0030145 | molecular_function | manganese ion binding |
L | 0046872 | molecular_function | metal ion binding |
L | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue BCT A 601 |
Chain | Residue |
A | LYS289 |
A | ALA372 |
A | GLU373 |
A | GLY374 |
A | ARG375 |
A | LEU402 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MN A 602 |
Chain | Residue |
A | MN603 |
A | HOH752 |
A | ASP294 |
A | ASP371 |
A | GLU373 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue MN A 603 |
Chain | Residue |
A | LYS289 |
A | ASP294 |
A | ASP312 |
A | GLU373 |
A | MN602 |
A | HOH708 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue BCT B 601 |
Chain | Residue |
B | LYS289 |
B | ALA372 |
B | GLU373 |
B | GLY374 |
B | ARG375 |
B | LEU402 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue MN B 602 |
Chain | Residue |
B | ASP294 |
B | ASP371 |
B | GLU373 |
B | MN603 |
B | HOH740 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue MN B 603 |
Chain | Residue |
B | LYS289 |
B | ASP294 |
B | ASP312 |
B | GLU373 |
B | MN602 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue BCT C 601 |
Chain | Residue |
C | LYS289 |
C | ALA372 |
C | GLU373 |
C | GLY374 |
C | ARG375 |
C | LEU402 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue MN C 602 |
Chain | Residue |
C | ASP294 |
C | ASP371 |
C | GLU373 |
C | MN603 |
C | HOH751 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue MN C 603 |
Chain | Residue |
C | LYS289 |
C | ASP294 |
C | ASP312 |
C | GLU373 |
C | MN602 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue BCT D 601 |
Chain | Residue |
D | LYS289 |
D | ALA372 |
D | GLU373 |
D | GLY374 |
D | ARG375 |
D | LEU402 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue MN D 602 |
Chain | Residue |
D | ASP294 |
D | ASP371 |
D | GLU373 |
D | MN603 |
D | HOH758 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue MN D 603 |
Chain | Residue |
D | LYS289 |
D | ASP294 |
D | ASP312 |
D | GLU373 |
D | MN602 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue BCT E 601 |
Chain | Residue |
E | LYS289 |
E | ALA372 |
E | GLU373 |
E | GLY374 |
E | ARG375 |
E | LEU402 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue MN E 602 |
Chain | Residue |
E | ASP294 |
E | ASP371 |
E | GLU373 |
E | MN603 |
E | HOH754 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue MN E 603 |
Chain | Residue |
E | LYS289 |
E | ASP294 |
E | ASP312 |
E | GLU373 |
E | MN602 |
site_id | AD7 |
Number of Residues | 6 |
Details | binding site for residue BCT F 601 |
Chain | Residue |
F | LYS289 |
F | ALA372 |
F | GLU373 |
F | GLY374 |
F | ARG375 |
F | LEU402 |
site_id | AD8 |
Number of Residues | 5 |
Details | binding site for residue MN F 602 |
Chain | Residue |
F | ASP294 |
F | ASP371 |
F | GLU373 |
F | MN603 |
F | HOH724 |
site_id | AD9 |
Number of Residues | 6 |
Details | binding site for residue MN F 603 |
Chain | Residue |
F | LYS289 |
F | ASP294 |
F | ASP312 |
F | GLU373 |
F | MN602 |
F | HOH724 |
site_id | AE1 |
Number of Residues | 6 |
Details | binding site for residue BCT G 601 |
Chain | Residue |
G | ALA372 |
G | GLU373 |
G | GLY374 |
G | ARG375 |
G | LEU402 |
G | LYS289 |
site_id | AE2 |
Number of Residues | 5 |
Details | binding site for residue MN G 602 |
Chain | Residue |
G | ASP294 |
G | ASP371 |
G | GLU373 |
G | MN603 |
G | HOH754 |
site_id | AE3 |
Number of Residues | 5 |
Details | binding site for residue MN G 603 |
Chain | Residue |
G | LYS289 |
G | ASP294 |
G | ASP312 |
G | GLU373 |
G | MN602 |
site_id | AE4 |
Number of Residues | 6 |
Details | binding site for residue BCT H 601 |
Chain | Residue |
H | LYS289 |
H | ALA372 |
H | GLU373 |
H | GLY374 |
H | ARG375 |
H | LEU402 |
site_id | AE5 |
Number of Residues | 5 |
Details | binding site for residue MN H 602 |
Chain | Residue |
H | ASP294 |
H | ASP371 |
H | GLU373 |
H | MN603 |
H | HOH747 |
site_id | AE6 |
Number of Residues | 6 |
Details | binding site for residue MN H 603 |
Chain | Residue |
H | LYS289 |
H | ASP294 |
H | ASP312 |
H | GLU373 |
H | MN602 |
H | HOH739 |
site_id | AE7 |
Number of Residues | 6 |
Details | binding site for residue BCT I 601 |
Chain | Residue |
I | LYS289 |
I | ALA372 |
I | GLU373 |
I | GLY374 |
I | ARG375 |
I | LEU402 |
site_id | AE8 |
Number of Residues | 5 |
Details | binding site for residue MN I 602 |
Chain | Residue |
I | ASP294 |
I | ASP371 |
I | GLU373 |
I | MN603 |
I | HOH744 |
site_id | AE9 |
Number of Residues | 5 |
Details | binding site for residue MN I 603 |
Chain | Residue |
I | LYS289 |
I | ASP294 |
I | ASP312 |
I | GLU373 |
I | MN602 |
site_id | AF1 |
Number of Residues | 6 |
Details | binding site for residue BCT J 601 |
Chain | Residue |
J | LYS289 |
J | ALA372 |
J | GLU373 |
J | GLY374 |
J | ARG375 |
J | LEU402 |
site_id | AF2 |
Number of Residues | 5 |
Details | binding site for residue MN J 602 |
Chain | Residue |
J | ASP294 |
J | ASP371 |
J | GLU373 |
J | MN603 |
J | HOH789 |
site_id | AF3 |
Number of Residues | 5 |
Details | binding site for residue MN J 603 |
Chain | Residue |
J | LYS289 |
J | ASP294 |
J | ASP312 |
J | GLU373 |
J | MN602 |
site_id | AF4 |
Number of Residues | 6 |
Details | binding site for residue BCT K 601 |
Chain | Residue |
K | LYS289 |
K | ALA372 |
K | GLU373 |
K | GLY374 |
K | ARG375 |
K | LEU402 |
site_id | AF5 |
Number of Residues | 5 |
Details | binding site for residue MN K 602 |
Chain | Residue |
K | ASP294 |
K | ASP371 |
K | GLU373 |
K | MN603 |
K | HOH767 |
site_id | AF6 |
Number of Residues | 5 |
Details | binding site for residue MN K 603 |
Chain | Residue |
K | LYS289 |
K | ASP294 |
K | ASP312 |
K | GLU373 |
K | MN602 |
site_id | AF7 |
Number of Residues | 6 |
Details | binding site for residue BCT L 601 |
Chain | Residue |
L | LYS289 |
L | ALA372 |
L | GLU373 |
L | GLY374 |
L | ARG375 |
L | LEU402 |
site_id | AF8 |
Number of Residues | 5 |
Details | binding site for residue MN L 602 |
Chain | Residue |
L | ASP294 |
L | ASP371 |
L | GLU373 |
L | MN603 |
L | HOH758 |
site_id | AF9 |
Number of Residues | 5 |
Details | binding site for residue MN L 603 |
Chain | Residue |
L | LYS289 |
L | ASP294 |
L | ASP312 |
L | GLU373 |
L | MN602 |
Functional Information from PROSITE/UniProt
site_id | PS00631 |
Number of Residues | 8 |
Details | CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRI |
Chain | Residue | Details |
A | ASN369-ILE376 |