5NS9

Crystal structure of the GluA2 LBD (L483Y-N754S-L758V) in complex with glutamate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 1PE A 301

Chain	Residue
A	LYS117
A	HOH484
A	HOH529
A	HOH769
A	GLU201
A	GLN202
A	LYS226
A	SER228
A	CYS261
A	GLY262
A	SER263
A	1PE302

---

site_id	AC2
Number of Residues	11
Details	binding site for residue 1PE A 302

Chain	Residue
A	VAL6
A	PHE49
A	SER228
A	SER229
A	CYS261
A	GLY262
A	SER263
A	1PE301
A	HOH412
A	HOH514
A	HOH595

---

site_id	AC3
Number of Residues	7
Details	binding site for residue PG0 A 303

Chain	Residue
A	LYS4
A	VAL7
A	LYS82
A	ASP84
A	PRO205
A	HOH493
A	HOH645

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 304

Chain	Residue
A	ARG149
A	HOH432
A	HOH482

---

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 A 305

Chain	Residue
A	LYS21
A	ARG203
A	LYS204
A	GLU260
A	HOH473
A	HOH664

---

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 A 306

Chain	Residue
A	ARG148
A	TRP159
A	ARG163
A	HOH403
A	HOH482
A	HOH667

---

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 A 307

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	HOH427
A	HOH440
A	HOH450
A	HOH581

---

site_id	AC8
Number of Residues	4
Details	binding site for residue NA A 308

Chain	Residue
A	GLU97
A	ILE100
A	ASP101
B	HOH415

---

site_id	AC9
Number of Residues	5
Details	binding site for residue NA A 309

Chain	Residue
A	ARG149
A	HOH656
B	GLU243
B	GLN244
B	HOH784

---

site_id	AD1
Number of Residues	5
Details	binding site for residue NA A 310

Chain	Residue
A	LEU215
A	HOH456
B	ASP248
B	HOH721
B	HOH772

---

site_id	AD2
Number of Residues	13
Details	binding site for residue GLU A 311

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193
A	TYR220
A	HOH495
A	HOH507
A	HOH512

---

site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 B 301

Chain	Residue
B	ARG31
B	HOH437
B	HOH443
B	HOH450
B	HOH489
B	HOH662

---

site_id	AD4
Number of Residues	8
Details	binding site for residue SO4 B 302

Chain	Residue
B	ASP139
B	SER140
B	LYS144
B	ARG148
B	HOH402
B	HOH424
B	HOH444
B	HOH451

---

site_id	AD5
Number of Residues	5
Details	binding site for residue NA B 303

Chain	Residue
B	THR9
B	THR54
B	VAL56
B	GLU77
B	HOH582

---

site_id	AD6
Number of Residues	6
Details	binding site for residue NA B 304

Chain	Residue
B	VAL211
B	GLY212
B	GLY213
B	LEU215
B	HOH416
B	ILE113

---

site_id	AD7
Number of Residues	13
Details	binding site for residue GLU B 305

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193
B	TYR220
B	HOH440
B	HOH498
B	HOH519

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---